ABSTRACT
To study the chemical constituents of Periplocae Cortex, the separation and purification of 70% alcohol extract were carried out by column chromatographies on AB-8 macroporous resin, silica gel and preparative HPLC. The structure of the compounds were identified by NMR and TOF-MS. A new compound was isolated and identified as 21-O-methyl-Δ5-pregnene-3β, 14β, 17β, 21-tetraol-20-one-3-O-β-D-oleandropyranosyl(1-->4)-β-D-cymaropyranosyl-(1-->4)-β-D-cymaropyranosyl (1), named as periplocoside P.
Subject(s)
Glycosides , Chemistry , Periploca , Chemistry , Pregnenes , Chemistry , Saponins , ChemistryABSTRACT
Ginsenoside Rb1 is a representative component of panaxadiol saponins, which belongs to dammarane-type tritepenoid saponins and mainly exists in family araliaceae. It has been reported that ginsenoside Rb1 has diverse biological activities. In this paper, the research development in recent decade on its pharmacological effects of cardiovascular system, anti-senility, reversing multidrug resistance of tumor cells, adjuvant anti-cancer chemotherapy, promoting peripheral nerve regeneration, et al, are reviewed.
Subject(s)
Animals , Humans , Aging , Cardiovascular System , Pathology , Drug Resistance, Neoplasm , Ginsenosides , Metabolism , Pharmacokinetics , Pharmacology , Nerve RegenerationABSTRACT
<p><b>OBJECTIVE</b>To provide scientific basis for the selection of agrotype and property fertilization for Rumex gmelini cultivated in compliance with good agricultural practice (GAP).</p><p><b>METHOD</b>HPLC method was applied to determinate the content of seven active constituents (resveratrol, polydatin, chrysophanol 1-glucoside, nepodin, emodin, chrysophanol and physcion) of annual R. gmelini. And the correlation between soil nutrients and content of active constituents in the root of R. gmelini were analyzed by stepwise regression analysis.</p><p><b>RESULT</b>Seven regression equation were established. The statistic significance was found in three of them.</p><p><b>CONCLUSION</b>The soil with high total K level is not suitable for R. gmelini cultivation. But the higher available N, available P, available K level of soil is suitable.</p>
Subject(s)
Anthraquinones , Ecosystem , Emodin , Fertilizers , Glucosides , Nitrogen , Phosphorus , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Potassium , Regression Analysis , Rumex , Chemistry , Soil , StilbenesABSTRACT
<p><b>OBJECTIVE</b>To establish a method used for optimization of harvesting time and determine the best time for harvesting Rumex gmelini.</p><p><b>METHOD</b>An HPLC method was applied to determinate the contents of seven active constituents(resveratrol, polydatin, chrysophanol 1-glucoside, nepodin, emodin, chrysophanol and physcion)of R. gmelini at different development stage. The result was analyzed by principal component analysis.</p><p><b>RESULT</b>The accumulation of active constituents showed a regular pattern.</p><p><b>CONCLUSION</b>The best harvesting time of R. gmelini is early July.</p>