ABSTRACT
Objective To study the CT perfusion imaging features of pancreas under liver cirrhosis.Methods 191 cases including 48 normal controls(group A)and 143 patients with liver cirrhosis(group B)were randomly collected according to the inclusion and exclusion criteria.The scope of pancreatic perfusion imaging scan was determined based on conventional plain CT scan of middle and upper abdomen.All patients were injected with contrast agent at the antecubital vein tunnel group and then with normal saline at the same rate.The original perfusion images were transmitted to the workstation and were analyzed by the pancreatic perfusion software package,and the perfusion parameters were recorded for statistical analysis.Results (1)There were statistical differences in pancreatic perfusion parameter values,namely blood flow(BF),blood volume(BV)and mean transit time(MTT),between group A and group B(P<0.05).BF and BV of group B were lower than those of group A but MTT was higher than that of group A,and there was no statistical difference in permeability surface(PS)(P>0.05).(2)For group B,each pancreas part(head,body and tail)had no statistical difference in perfusion parameter values,namely BF,BV,PS and MTT(P>0.05).(3)For group B which was divided into three groups according to Child-Pugh,there were statistical differences in parameter values BF and BV(P<0.05)among the three groups and no statistical differences in BF and BV among any two of the groups(P<0.05);there were no statistical differences in PS and MTT among the three groups.(4)In group B,there was a statistical difference in BF between the subgroup with collateral circulation and the one without collateral circulation(P<0.05),the subgroup with collateral circulation showed lower BF than that of the subgroup without collateral circulation and there were no statistical differences in BV,PS and MTT(P>0.05).Conclusion Liver cirrhosis can result in microcirculation disturbance of pancreas,the change in microcirculation varies depending on the degree of liver cirrhosis, and CT perfusion imaging is helpful to the evaluation of pancreatic microcirculation in the state of liver cirrhosis.
ABSTRACT
Hepatocellular adenomas (HCA) are rare benign tumors of the liver, and according to the differences in molecular genetics and pathology, HCA is categorized as inflammatory hepatocellular adenoma (IHCA), HCA with hepatocyte nuclear factor 1-alpha mutation (H-HCA), HCA with β-catenin mutation (β-HCA), and an undefined type. The incidence of these four types is 40%-50%, 30%-40%, 10%-15%, and 10%, respectively. In these four types of HCA, β-HCA has high risk of bleeding and malignant transformation, while H-HCA is not likely to show malignant transformation. Therefore, the accurate diagnosis of these types of HCA is very important. This article introduces the radiological features of these types of HCA on conventional MRI and hepatocyte-targeted contrast-enhanced scan and compares these findings with other types of liver solid tumors such as focal nodular hyperplasia, nodular regenerative hyperplasia, liver cancer in non-cirrhotic patients, and fibrolamellar carcinoma of the liver. It is pointed out that MRI and hepatocyte-targeted contrast agents play an important role in the diagnosis and differentiation of HCA.
ABSTRACT
In recent years ,the diffusion magnetic resonance imaging in the study of breast cancer is in-creasing,which including diffusion weighted imaging ,diffusion tensor imaging ,intravoxel incoherent motion ,and diffusion kurtosis imaging .The emergence and development of these technologies can be noninvasive quantitative evaluation of breast tumors from the molecular level .The researchers pay more and more attention to the applica-tion of breast cancers diagnosis and differential diagnosis ,therapeutic effect ,prognosis evaluation and so on .This paper reviews the progresses of the above four technologies in the use of the breast cancer .