ABSTRACT
The establishment of immune system is an orchestrated process from hematopoietic stem cells to immune effector cells.Hematopoietic stem cells development into variety of immune cell subsets with high pluripotency.However,effector immune cells possess specific function with limited pluripotency.Recently,researchers found that differentiated immune cells were able to transdifferentiate to other cell types accompanied with the conversion of effector functions.The plasticity of immune cell subsets were confirmed in many subsets such as T cell,innate lymphoid cell,macrophage,neutrophil and so on.The transdifferentiation of immune cells is accompanied with the process of many diseases.Study on plasticity of immune cells will provide important theoretic basis to clinic trail.In this review,we summarized the subsets,regulatory mechanism,and related diseases about immune cell plasticity.