ABSTRACT
Objective To investigate the relationship between single nucleotide polymorphisms of interleukin 23 receptor (IL-23R) gene and Keshan disease (KD) in Northwest Chinese Han population.Methods A total of 285 Chinese Han subjects from Huangling,Shaanxi,including 79 KD patients (case group) and 206 control subjects (control group) were involved in this study.Genomic DNA was extracted from peripheral venous blood.The polymorphism of genetic variation was genotyped by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF).All sample groups were tested for Hardy-Weinberg equilibrium using goodness-of-fit x2 test.Differences in genotype distribution between two groups were compared by x2 test.Logistic regression analysis was applied to detect association using age as a confounding factor.Results The gene frequency distribution of IL-23R gene rs10889677 in case group and control group conformed to the Hardy-Weinberg equilibrium (x2 =0.254,P ＞ 0.05).Correlation analysis results:the difference of genotype frequency of IL-23R gene rs10889677 in case group (CC,CA,AA were 6.3％,36.7％,57.0％,respectively) and control group (CC,CA,AA were 5.3％,43.2％,51.5％,respectively) was not statistically significant (x2 =1.008,P ＞ 0.05).After age adjustment,there was no significant difference in genotype frequency of IL-23R gene rs10889677 (x2sdj =0.669,P ＞ 0.05) between two groups.Conclusion There is no correlation between IL-23R gene rs10889677 and KD in Northwest Chinese Han population.
ABSTRACT
This paper reports diagnostic results of 200 cases of hemoptysis. The causes of hemoptysis mainly include: bronchial and pulmonary infections (28%), tracheal,bronchial and pulmonary tumor (22.5%),tuberculosis (9.5%), pulmonary abscess (4%), other pulmonary diseases (2.5%), dosprders pitside the lungs (6.5%), and diseases of unidentified reason (5.5%). The diagnostic procedure of hemoptysis is also discussed. It is especially emphasized that the Pulmonary biopsy via bronchia and technique of systematic segmental lavage are of crucial importance for the diagnosis of hemoptysis.
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This paper reports 9 cases of Marfan syndrome treated from 1984 to 1989. Among the 9 cases, 7 cases had abnormality, of eyes. 8 cases had abnormality of skeleton and 8 cases had abnormality in the cardiavescular system. 3 cases wer accompanied by angina pectoris. 1 case by SIE and thrombosis of aortic root was confirmed by autopsy in 1 case. The pathological process, prognosis and treatment of this syndrome have also been discussed briefly in the paper.