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0.05) in incidence rate for bone marrow suppression,gastrointestinal reaction,hepatic damage and mucosa damage and infection between different therapic courses.Central nervous system leukemia(CNSL) occured in one high risk case followed up at 12 month after complete remission(CR);the incidence rate was 12.5%.Conclusions HD-MTX is practicable in basic-level hospitals,as long as there are perfect preparation,fitness hydration and alkalization and leucovorin rescue being used in time.
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Objective To evaluate the relationship of intraerythrocytic calcium(Ca~(2+)),serum cardiac troponin I(cTnI) and contractile and diastolic dysfunction in infants with pneumonia complicated with heart failure(HF),and discuss the role of Ca~(2+) and cTnI.(Met)-hods One hundred and thirty-three infants with pneumonia complicated with HF and 30 healthy children were studied.Intraerythrocytic calcium,serum cTnI and ejection fraction(EF),fractional shortening(FS) and E/A were measured by color Doppler ultrasoundraphy.Results Intraerythrocytic calcium,serum cTnI and EF,FS and E/A in two groups had difference.With the disease deteriorating,the values of Ca~(2+) and cTnI increased,and EF,FS,E/A decreased gradually.There were negative relations between Ca~(2+),cTnI and EF,FS,E/A.Conclusions Ca~(2+),cTnI are concerned with the development of HF.In clinical experiments,the contractile function and diastolic function of heart can be judged by the levels of intraerythrocytic calcium and serum cTnI.
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Objective To study the changes of serum endotheline(ET),D-dimer and fibrinogen(Fbg) in infants with pneumonia complicated with heart failure(HF) and explore the changes of blood coagulation,fibrinolysis,and endothelial cell function.Methods Eighty patients with infant pneumonia complicated with HF and 20 controls were studied.Serum ET,D-dimer,Fbg,activated partial thromboplastin time(APTT),prothrombin time(PT) and thrombin time(TT) were measured.Results ET,D-dimer,Fbg,APTT in every group had differences.With the disease deteriorating,the values of ET,D-dimer,Fbg increased,but the values of APTT decresed gradually.There were positive relations between ET and D-dimer(r=0.42 P