ABSTRACT
Picornaviridae 2C gene is relatively conservative,whose encoded protein is a non-structural protein.The 2C protein is in an earlier detection and only can be detected during virus replicatin.The 2C protein has multiple fuctions:the role of AAA+ helicase activity,invasion cells by autophagy pathway,abduction cells on inflammation and apoptosis;the interaction with other proteins such as 2B and 3C that might be induced by 2C protein,which can participate in the pathogenic process in a way.Above all,we mainly outline the reseach advances on Picornaviridae 2C gene and its encoded protein,in order to provide some superficial reference for its further study.
ABSTRACT
Postural orthostatic tachycardia syndrome (POTS) is characterized by orthostatic intolerance, a presentation of autonomic dysfunction which is frequently observed in the patients with multiple sclerosis (MS). Nevertheless, to date, there have been a few studies focusing on POTS in MS patients and the underlying pathomechanism. We present a 28-year-old woman with relapsing-remitting opticspinal multiple sclerosis who also suffered POTS and discuss the possible pathomechanism of POTS in MS.