Serum levels of insulin-like growth factor-1 in neonates with hyperbilirubinemia / 中国当代儿科杂志

<p><b>OBJECTIVE</b>Insulin-like grouth factor-1 (IGF-1) is polypetide hormone that has demonstrated effects on neural cells. Up to now, there is few reports about the relation between serum IGF-1 and brain damage in neonates with hyperbilirubinemia. This study explored the potential role of serum IGF-1 in neonatal hyperbilirubinemia.</p><p><b>METHODS</b>Serum levels of IGF-1 were measured using ECLIA in 57 term neonates with hyperbilirubinemia and 25 normal term neonates. Meanwhile, total serum bilirubin (TSB), unconjugated bilirubin (USB) and serum albumin (ALB) contents were measured by the automatic biochemistry analyzer and the ratio of USB/ALB (B/A) was calculated. The hyperbilirubinemia group was classified into three subgroups based on serum TSB levels: mild (221-256 micromol/L), moderate (257-342 micromol/L) and severe (>342 micromol/L). Serum TSB levels in the 25 normal neonates were less than 85 micromol/L (control group). NBNA was performed on the day of serum sample collection.</p><p><b>RESULTS</b>Serum IGF-1 levels in the mild, moderate and severe hyperbilirubinemia groups (39.38+/- 8.42, 30.77+/- 4.65 and 26.34+/- 2.05 ng/L, respectively) were obviously lower than those in the control group (50.16+/- 15.73 ng/L) (P< 0.01). There were significant differences among the three hyperbilirubinemia subgroups in serum IGF-1 levels (P< 0.01). Mean NBNA scores in the mild, moderate and severe hyperbilirubinemia groups (35.01+/- 2.26, 32.45+/- 2.74 and 26.77+/- 5.02, respectively) were significantly lower than those in the control group (38.24+/- 0.78) (P< 0.01). Significant differences in the NBNA scores were noted among the three hyperbilirubinemia subgroups (P< 0.01). Serum IGF-1 levels were positively correlated to NBNA scores (r=0.603, P< 0.01) and negatively correlated to the ratio of B/A (r=-0.483, P< 0.01).</p><p><b>CONCLUSIONS</b>Serum IGF-1 levels decreased obviously in neonates with hyperbilirubinemia and correlated to the severity of disease. IGF-1 might be associated with bilirubin-induced brain damage.</p>

Changes of Humoral Immunity in Newborn Infants with Hypoxic-Ischemic Encephalopathy and Its Correlative Factors / 实用儿科临床杂志

Objective To explore the changes of humoral immunity in neonates with hypoxic-ischemic encephalopathy(HIE)and observe the influence of perinatal factors on humoral immune function.Methods Sixty-two neonates with HIE were enrolled and 30 healthy neonates were selected as control group.The percentages of CD19,CD25 of B lymphocyte were detected by Flow Cytometr.The levels of IgG,IgM,IgA and complement C3,C4 were detected by immune rate nephewlometry.The results were analyzed by SPSS 11.5 software.Results 1.The percentages of CD19+(17.93?3.10)%,CD19+CD25+(0.64?0.42)% and the levels of IgM(0.13?0.05)g/L,IgA(0.14?0.07)g/L and complement C3(0.62?0.12)g/L,C4(0.10?0.03)g/L in neonates with HIE were significantly lower than those in the healthy term neonates(Pa0.05).2.There were dignificant diffe-rences of the percentages of CD19+,CD19+CD25+ and the levels of IgM,IgA,complement C3,C4 among the different stages of HIE(Pa