ABSTRACT
Objective To analyze the epidemiological characteristics of malaria in Leshan City,so as to provide the evi-dence for formulating the strategy and measures for consolidating the achievements of malaria elimination. Methods The data of epidemiological characteristics of malaria in Leshan City from 1950 to 2015 were collected and analyzed with the descriptive epidemiology method. Results There were four larger scale epidemics of malaria in Leshan City from 1950 to 2015. The order of malaria in infectious diseases dropped from the first to the twentieth. The peak season for malaria epidemics ceased. The Plas-modium species,patient age,occupation and sex distribution of malaria were different in the different periods. In November 2016,the whole city achieved the national standard for malaria elimination. Conclusions After years of prevention and con-trol,the epidemiological characteristics of malaria have changed significantly in Leshan City,and the effect of anti-malarial mea-sures is significant. In the future,we should strengthen the monitoring,and prevention and control of imported malaria.
ABSTRACT
Both AM1 semi-empirical quantum chemistry method and HF/3-21g* ab initio method were employed to get related parameters or descriptors, particularly, the parameters of the solvation energy delta G with polarizable continuum model, for 42 anti-HIV 5-phenyl-1-phenylamino-1H-imidazole derivatives with known cytotoxicity. With parameters of quantum chemical calculation and traditional ones, 2 multiple linear regression models were obtained. The better regression equation has a high correlation coefficient (r = 0.938) and a low standard deviation (s = 0.125) and the squared correlation coefficient Q2 of the cross-validation is 0.799 (literaure: 0.740) by leave-one-out method. The results have certain significance for the design of new anti-HIV-1 drugs with lower cytotoxicity.