ABSTRACT
Objective To explore the influence of inhaled corticosteroids on the curative effect and fiactional exhaled nitric oxide and endothelial function for patients with stable COPD.Methods Totally 90 patients with stable COPD were collected in Xinxiang Central Hospital from July 2014 to July 2016,and divided into two groups randomly.The control group (n =45) was treated with conventional Western medicine,the observation group (n =45) were given fluticasone propionate inhalation atomization of 250 g per time,twice daily.The two groups received 6 months of treatment.The pulmonary function indexes including forced vital capacity (FVC),1 s forced expiratory volume (FEV1),maximal mid expiratory flow (MMEF) and peak expiratory flow (PEF),inflammatory factors such as lnterleukin-6 (IL-6),interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and C reactive protein (CRP) levels,and vascular endothelial function indexes including flow-mediated vasodilation (FMD),soluble intercellular adhesion molecule-1 (SICAM-1),endothelin 1 (ET-1),and fractional exhaled nitric oxide (FENO) were compared and analyzed.Results After treatment,the pulmonary function indexes were improved significantly (P ＜ 0.05),and the FEV1,FEV1/FVC,MMEF,and PEF of observation group were higher significantly than those patients in control group (P ＜ 0.05).The levels of inflammatory factors decreased than before treatment remarkably (P ＜ 0.05),and the levels of IL-6,IL-8,TNF-α,and CRP in observation group were lower than those in control group,and which difference was significance (P ＜ 0.05).The FMD of patients in study group was higher than those in control group significantly (P ＜ 0.05).The levels of SICAM-1 and ET-1 in observation group were decreased significantly than those before treatment,and were lower than control group (P ＜ 0.05).The FENO of all patients decreased than before treatment,and reduced amplitude in observation group was more than those in control group significantly (P ＜ 0.05).Conclusion Inhaled corticosteroids for patients stable COPD could improve pulmonary functions and inhibit inflammatory response,specially,which improves endothelial function and reduces the amount of exhaled NO and occurrence of cardiovascular events.
ABSTRACT
Objective To understand the forming cause of the Oncomelania hupensis snail-existent non-endemic areas of schistosomiasis(SENEAS),and to verify the conclusion of previous studies,so as to provide the evidence for schistosomiasis monitoring in such areas in Nantong City,Jiangsu Province. Methods The controlled field tests were carried out to observe the O. hupensis snails artificially infected by schistosome miracidia in SENEAS. The influence of the soil from SENEAS and the en-demic areas on O. hupensis snails artificially infected by miracidia were observed. Results All the experimental snails could be infected by schistosome miracidia except the smooth-shell snails from Tangyuan Village in the controlled field test environment of SENEAS or the endemic areas. The infection rates of the smooth-shell snails were lower than those of the ribbed-shell snails , but there were no statistically significant differences. The mortality rates of the smooth-shell snails were higher than those of the ribbed-shell snails,which were statistically significant (χ2Xindian = 135.118,χ2Shuangdian = 122.836,χ2Baipu =154.436,χ2Dingyan =138.288,χ2Control=151.923,all P<0.01). There were no significant differences in the infection rates of snails between each test group of the soil from SENEAS and the endemic areas(χ2Rugao=0.071,χ2Rudong=0.216,both P>0.05). Also there was no signifi-cant difference between each test group and the control group without soil(χ2=7.148,P>0.05). Conclusion It is likely to form the spread of schistosomiasis in SENEAS in Nantong City with sufficient amount of infection source of schistosomiasis im-ported. It is still necessary to implement the surveillance of schistosomiasis and O. hupensis snails in Nantong City.
ABSTRACT
Objective To explore the influence of inhaled corticosteroids on the curative effect and fiactional exhaled nitric oxide and endothelial function for patients with stable COPD.Methods Totally 90 patients with stable COPD were collected in Xinxiang Central Hospital from July 2014 to July 2016,and divided into two groups randomly.The control group (n =45) was treated with conventional Western medicine,the observation group (n =45) were given fluticasone propionate inhalation atomization of 250 g per time,twice daily.The two groups received 6 months of treatment.The pulmonary function indexes including forced vital capacity (FVC),1 s forced expiratory volume (FEV1),maximal mid expiratory flow (MMEF) and peak expiratory flow (PEF),inflammatory factors such as lnterleukin-6 (IL-6),interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and C reactive protein (CRP) levels,and vascular endothelial function indexes including flow-mediated vasodilation (FMD),soluble intercellular adhesion molecule-1 (SICAM-1),endothelin 1 (ET-1),and fractional exhaled nitric oxide (FENO) were compared and analyzed.Results After treatment,the pulmonary function indexes were improved significantly (P ＜ 0.05),and the FEV1,FEV1/FVC,MMEF,and PEF of observation group were higher significantly than those patients in control group (P ＜ 0.05).The levels of inflammatory factors decreased than before treatment remarkably (P ＜ 0.05),and the levels of IL-6,IL-8,TNF-α,and CRP in observation group were lower than those in control group,and which difference was significance (P ＜ 0.05).The FMD of patients in study group was higher than those in control group significantly (P ＜ 0.05).The levels of SICAM-1 and ET-1 in observation group were decreased significantly than those before treatment,and were lower than control group (P ＜ 0.05).The FENO of all patients decreased than before treatment,and reduced amplitude in observation group was more than those in control group significantly (P ＜ 0.05).Conclusion Inhaled corticosteroids for patients stable COPD could improve pulmonary functions and inhibit inflammatory response,specially,which improves endothelial function and reduces the amount of exhaled NO and occurrence of cardiovascular events.