ABSTRACT
BACKGROUND:Unclear pathogenesis of osteoarthritis results in a lack of radical therapy.The current studies mainly focus on pain relief and joint function improvement.Establishing an animal model is helpful to explore the pathogenesis,prevention and treatment of osteoarthritis,and also contributes to develop health food with new functions used for preventing and improving osteoarthritis.OBJECTIVE:To overview the establishment of the osteoarthritic animal model and its application in functional food research,thereby providing scientific basis for reasonable selection of ostecarthritic animal models and screening tests of bioactive substances.METHODS:CNKI and PubMed databases were retrieved for the articles related to animal model establishment published before May,2016,using the keywords of "osteoarthritis,animal model" in Chinese and English,respectively.Totally 157 articles were searched initially after repetitive ones excluded,and then 59 eligible articles were included.RESULTS AND CONCLUSION:Animal models of osteoarthritis are established in a variety of ways,and have their own advantages and disadvantages,with different application scopes.Therefore,we need select and establish appropriate animal models used for studying the pathogenesis of osteoarthritis and screening more specific and effective substances that can prevent and improve osteoarthritis.Additionally,it is of great significance for further developing the corresponding functional health food to alleviate the patients' pain and improve their quality of life.