ABSTRACT
Objective To study the effect of minimal enteral feeding and mechanic ventilation on motilin(MTL) in premature infants and find a new way to promote gastrointestinal motility especially in critical illness,so as to develop their nutritional condition.Methods From Nov.2004 to Jun.2006, 60 premature infants were recruited at NICU of Xi′an children′s hospital,who were assigned to minimal enteral feeding and normal feeding groups,mechanic ventilationor non-mechanic ventilation was conducted based on premature infants′ illness.Their peripheral vein blood was collected at different time respectively: before their first breast-feeding,3 and 7 days after their birth and their MTL levels was measured by radioimmunoassay.The effect of 2 factors on hormones were factorially analyzed.The difference of gastrointestinal motility between 2 feeding groups.Results Mechanic ventilation could not alter MTL levels.But minimal feeding could significantly promote motilin′s secretion(P0.05).None of patients suffered from necrotizing enterocolitis.Conclusion Minimal enteral feeding can significantly increase gastrointestinal motility of premature infants,as well as those infants who are conducted mechanic ventilation.