ABSTRACT
Recurrence and metastasis are important characteristics of malignant tumors , and also the main cause of death . How to prevent and control tumor recurrence and metastasis is an important subject to be solved urgently .In recent years, in addition to the function of hemostasis and thrombosis , a large number of studies have confirmed that platelets also play an important role in the oc -currence and development of malignant tumors .This review article focuses on the following five aspects of tumor invasion and metasta-sis:the protection of tumor cells , platelet aggregation and adhesion to promote tumor cell metastasis , platelet-promoting tumor cell exu-dation, platelet in tumor angiogenesis and the role of platelet particles .
ABSTRACT
The occurrence of breast cancer therapy resistance is one of the most important reasons for the failure of breast cancer treatment.Once there was therapy resistance,breast cancer patients will suffer from advance of the cancer,replace of the tumor and distance metastasis,which will cause decrease of the quality of life and increase of the mortality rate.Long non-coding RNA (lncRNA) plays a very important role in the tumorigenesis and development.There are few reports about lncRNA in the resistance of breast cancer at home and abroad,especially in the field of molecular targeted therapy.However,understanding the role of lncRNA in the therapy resistance of breast cancer can effectively improve the effectiveness of several treat approaches of breast cancer.This article reviews the function of lncRNA in breast cancer chemotherapy,endocrine therapy and molecular targeted therapy and further clarify its molecular mechanism.