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BACKGROUND: Senile unstable intertrochanteric fractures are usually treated with intramedullary nail fixation, but for stable intertrochanteric fractures, extramedullary fixation and intramedullary nail both can obtain satisfactory curative efficacy. Therefore, surgical options are still a controversy.OBJECTIVE: To investigate the effect of percutaneous compression plate (PCCP) versus proximal femoral nail anti-rotation (PFNA) on the postoperative functional recovery of the elderly with stable intertrochanteric fractures and to observe the rotational stability and nail slipping.METHODS: Totally 86 elderly patients with stable intertrochanteric fracture were randomly divided into two groups, and then underwent PCCP or PFNA. The operation time, intraoperative blood loss, postoperative hemoglobin level, the time of weigh bearing, and fracture healing time were recorded; Harris hip scores at postoperative 4 weeks were detected to assess the functional recovery; the rotation rate of femoral head and incidence of nail slipping at 4 weeks postoperatively,as well as the complications within 6 months postoperatively were analyzed statistically.RESULTS AND CONCLUSION: (1) The intraoperative and postoperative declined levels of hemoglobin in the PFNA group were significantly higher than those in the PCCP group (P < 0.05). (2) There was no significant difference for in the Harris hip scores between two groups at postoperative 4 weeks (P > 0.05). The weight bearing time and fracture healing time in the PFNA group were significantly shorter than those in the PCCP group (P < 0.05). (3) The rotation rate of femoral head and nail slipping in the PFNA group were significantly lower than those in the PCCP group (P < 0.05). (4) The incidence of complications within 6 months postoperatively did not differ significantly between two groups (P > 0.05).(5) These results suggest that there is no significant difference in the postoperative function recovery and complications between PCCP and PFNA in the treatment of senile femoral intertrochanteric fracture fixation. However, PFNA possesses advantages in the rotation rate of femoral head and nail slipping.
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Objective To investigate the clinical efficacy of alprostadil combined with butylphthalide on patients with acute ischemic stroke and its effect on hs-CRP.Methods Eighty-five patients with acute ischemic stroke admitted into our hospital were divided randomly into observation group (n =42) and control group (n =43).Patients in control group were treated with alprostadil,and those in observation group were treated with alprostadil combined with butylphthalide.The neurologic impairment score (NIHSS),ADL score,hs-CRP,coagulation function,and clinical efficacy in the two groups were observed and compared.Results After 14 days of treatment,the NIHSS and ADL score in both groups were improved,and NIHSS in observation group were much lower than control group,ADL were much higher,and hs-CRP were markedly lower than that of control (P ＜ 0.05).And the coagulation function indexes in both groups were obvious lowered,and DD and FIB in observation group were conspicuously lower than those in control group,and PT were much higher (P ＜ 0.05).In addition,observation group with effective rate of 90.5％ were significantly higher than that of control group with 72.1％ (P ＜ 0.05).Conclusion Compared with only alprostadil treatment,alprostadil combined with butylphthalide had a better capability of treating patients with acute ischemic stroke by improving coagulation function and neurologic function,and inhibiting levels of hs-CRP.
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Objective To investigate the clinical efficacy of alprostadil combined with butylphthalide on patients with acute ischemic stroke and its effect on hs-CRP.Methods Eighty-five patients with acute ischemic stroke admitted into our hospital were divided randomly into observation group (n =42) and control group (n =43).Patients in control group were treated with alprostadil,and those in observation group were treated with alprostadil combined with butylphthalide.The neurologic impairment score (NIHSS),ADL score,hs-CRP,coagulation function,and clinical efficacy in the two groups were observed and compared.Results After 14 days of treatment,the NIHSS and ADL score in both groups were improved,and NIHSS in observation group were much lower than control group,ADL were much higher,and hs-CRP were markedly lower than that of control (P ＜ 0.05).And the coagulation function indexes in both groups were obvious lowered,and DD and FIB in observation group were conspicuously lower than those in control group,and PT were much higher (P ＜ 0.05).In addition,observation group with effective rate of 90.5％ were significantly higher than that of control group with 72.1％ (P ＜ 0.05).Conclusion Compared with only alprostadil treatment,alprostadil combined with butylphthalide had a better capability of treating patients with acute ischemic stroke by improving coagulation function and neurologic function,and inhibiting levels of hs-CRP.