ABSTRACT
Objective To analyze adverse reaction of voriconazole in Zhejiang province,and provide reference for safe and rational clinical use of it. Methods Eighty-four cases of voriconazole ADR reported from 2013 to 2015 were analyzed in terms of sex,age,mode of administration,time of ADR,combined drug use,organ or system involvement,outcome,etc. Results In the 84 cases of voriconazole ADR,the number of males was higher than that of females,aged 22 to 95 years old,and most cases were more than 60 years of age,accounting for 75.00%.Forty-six cases were caused by intravenous infusion,accounting for 54.76%,31 ADR cases were caused by oral administration,accounting for 36.90%,7 ADR cases were caused by intravenous infusion and oral administration,accounting for 8.33%.In 20 cases,ADR occurred immediately or on the administration day, accounting for 23.81%,and ADR in 36 cases occurred 2 to 10 days after the administration,accounting for 42.86%.The clinical manifestations of ADR were mainly digestive system injury,accounting for 31.58%,and the liver function abnormality was most common,mainly caused by oral administration;visual impairment was the second,accounting for 17.54%,mainly caused by the intravenous infusion;the proportion of nervous system injury was 16.67%,and the proportion of systemic reactions accounted for 11.40%. Conclusion During the period of clinical use,doctors,pharmacists,and nurses should strengthen the propaganda and education,recognition and prevention of voriconazole's ADR.The qualified hospitals may monitor the blood concentration and achieve individualized administration,to reduce the occurrence of ADR.