ABSTRACT
Objective To investigate the clinical value of preoperative lymphocyte-to-monocyte ratio(LMR)in evaluating the prognosis of patients with stage T1 non-muscle invasive bladder cancer(NMIBC).Methods A total of 215 patients with stage T1 NMIBC who underwent transurethral resection of bladder tumor were enrolled.Clinical data were collected.Patients were followed up and their disease-free survival(DFS)and overall survival(OS)were recorded.The receiver operating characteristic(ROC)curve of preoperative LMR in detecting patient prognosis was used to determine the optimal cut-off value for LMR.Patients were divided into low LMR group(LMR <3.86,=77)and high LMR group(LMR ≥ 3.86,=138).Kaplan-Meier survival curves were explored to compare cumulative DFS and OS rates in patients with different LMR levels,and COX proportional hazards regression model was used to analyze factors associated with DFS and OS.Results All these 215 patients with T1 stage NMIBC were followed up for 2-92 months,and the DFS rate was 59.07% and OS rate was 65.12%.Kaplan-Meier curves showed that the cumulative DFS rate(=4.784,=0.029)and cumulative OS rate(=7.146, =0.008)in the low LMR group were significantly lower than those in the high LMR group.Tumor size ≥ 3 cm(=1.398,95% :1.042-1.875,=0.025),pathological grade G3(=1.266,95% :1.026-1.563,=0.028),and LMR ≥ 3.86(=2.347,95% :1.080-5.101,=0.031)were independent factors associated with DFS in patients with stage T NMIBC.In addition,tumor size ≥ 3 cm(=1.228,95% :1.015-1.484,=0.034),pathological grade G3(=1.366,95% :1.017-1.834,=0.038),and LMR<3.86(=2.008,95% :1.052-3.832,=0.035)were independent factors associated with OS in patients with T1 stage NMIBC. Conclusion Preoperative LMR is an independent factor associated with patients' prognosis in T1 stage NIMBC.Patients with low LMR tend to have higher risk of NMIBC progression and death.
Subject(s)
Humans , Disease-Free Survival , Lymphocytes , Cell Biology , Monocytes , Cell Biology , Prognosis , Retrospective Studies , Survival Rate , Urinary Bladder Neoplasms , Diagnosis , PathologyABSTRACT
Objective To observe influences of thermal insulation at different temperatures on changes of vital signs,and inflammatory factors in children with congenital dislocation of the hip joint during surgery and postoperative rehabilitation.Methods Totally 39 cases of children undergoing congenital dislocation hip surgery under general anesthesia were selected and randomly divided into 32℃,38℃ and 43℃ groups.Children patients in three groups were given forced air heating at 32℃,38℃ and 43℃,respectively.The body temperature and other vital signs of each group were recorded immediately after anesthesia induction and intubation (T0),during surgical biopsy (T1),at 1h after operation(T2),2 h after operation(T3) and at the end of operation(T4).The venous blood was taken at T0 and T4 to determine the serum TGF-β activation,TNF-α,IL-1β and IL-10.Results Compared with T0,the temperature of three groups increased at T1-4 (P＜0.05),and 38℃ group had the most reliable temperature maintenance.Compared with 32℃ and 43℃ groups,serum TNF-α and IL-1β significantly decreased and TGF-β and IL-10 significantly increased in 38℃ group at T4(P＜0.05).Children in 43℃ group developed more cases of fever compared with other two groups,and the difference was significant (P＜0.05).Conclusion Temperatures setting at 32℃,38℃ and 43℃ can guarantee stable vital signs during surgery,and address hypothermia before surgery and during anesthesia induction.Applying 38℃ gas heating can maintain normal intra-operative body temperature and effectively inhibit inflammatory response.
ABSTRACT
Objective To observe influences of thermal insulation at different temperatures on changes of vital signs,and inflammatory factors in children with congenital dislocation of the hip joint during surgery and postoperative rehabilitation.Methods Totally 39 cases of children undergoing congenital dislocation hip surgery under general anesthesia were selected and randomly divided into 32℃,38℃ and 43℃ groups.Children patients in three groups were given forced air heating at 32℃,38℃ and 43℃,respectively.The body temperature and other vital signs of each group were recorded immediately after anesthesia induction and intubation (T0),during surgical biopsy (T1),at 1h after operation(T2),2 h after operation(T3) and at the end of operation(T4).The venous blood was taken at T0 and T4 to determine the serum TGF-β activation,TNF-α,IL-1β and IL-10.Results Compared with T0,the temperature of three groups increased at T1-4 (P＜0.05),and 38℃ group had the most reliable temperature maintenance.Compared with 32℃ and 43℃ groups,serum TNF-α and IL-1β significantly decreased and TGF-β and IL-10 significantly increased in 38℃ group at T4(P＜0.05).Children in 43℃ group developed more cases of fever compared with other two groups,and the difference was significant (P＜0.05).Conclusion Temperatures setting at 32℃,38℃ and 43℃ can guarantee stable vital signs during surgery,and address hypothermia before surgery and during anesthesia induction.Applying 38℃ gas heating can maintain normal intra-operative body temperature and effectively inhibit inflammatory response.