Research advances in picornavirus 2C gene and its encoding protein / 中国人兽共患病学报

Picornaviridae 2C gene is relatively conservative,whose encoded protein is a non-structural protein.The 2C protein is in an earlier detection and only can be detected during virus replicatin.The 2C protein has multiple fuctions:the role of AAA+ helicase activity,invasion cells by autophagy pathway,abduction cells on inflammation and apoptosis;the interaction with other proteins such as 2B and 3C that might be induced by 2C protein,which can participate in the pathogenic process in a way.Above all,we mainly outline the reseach advances on Picornaviridae 2C gene and its encoded protein,in order to provide some superficial reference for its further study.