ABSTRACT
Objective Sepsis is the common cause of death among patients with severe pneumonia.The peroxisome prolifera tor-activated receptor γ (PPARγ),as a nuclear transcription factor,has an anti-inflammatory action.This study was to investigate the correlation of PPARγgene polymorphisms with the clinical outcome of sepsis in the Chinese Hans of East China.Methods Using modified multiple ligase detection reaction,we genotyped 13 mononucleotide polymorphism loci of PPARγ in 194 patients with pneumonia-induced sepsis.After adjusting for age,sex,smoking,drinking,and APACHE Ⅱ scores,we analyzed the correlation of PPARγ gene polymorphisms with the clinical outcomes of sepsis by unconditioned logistic regression analysis.Results Compared with the CC genotype,rs1801282 GC+GG significantly decreased the risk of severe organ dysfunction of the patients (OR=0.11,95％ CI:0.01-0.95,P=0.027).In comparison with the CC+CG genotype,rs2920502 GG markedly reduced the risk of death from sepsis (OR=0.22,95％ CI:0.04-0.99,P=0.043).Conclusion In the Chinese Hans of East China,PPARγgene polymorphisms may be associated with multiple organ dysfunction and death of the patients with pneumonia-induced sepsis.
ABSTRACT
The mitochondria are the prime source of ATP,and involved in many important processes in the cell cycle.Mito chondrial dysfunction will affect many important cell events.The acute or chronic injuries of CNS,including traumatic brain injury (TBI),will lead to mitochondrial dynamic imbalance by altering the expression and function of proteins that mediate fission and fusion.Recent studies have confirmed that mitochondrial DNA (mtDNA) polymorphism and changes of the mtDNA's epigenetics were related to the pathophysiologic process and outcome of TBI.This review will introduce the normal anatomy and physiology of the mitochondrial to explore the possible relationship between the mitochondria and TBI,We will also review the studies which focus on the link of mitochondrial gene polymorphism and epigenetics change with TBI.