ABSTRACT
Aim To evaluate the effects of salvianolic acid B ( Sal B ) on bone metabolism and its potential mechanism in high fat diet ( HFD) mice.Methods Thirty C57BL/6J male mice were divided into three groups with 10 mice each, namely normal , HFD and HFD+Sal B.HFD and HFD+Sal B mice were treated with HFD, and HFD+Sal B group mice were also with Sal B (125 mg· kg -1· d-1).After 12 weeks' treat-ment, femurs were harvested .The effects of Sal B on biomechanical strength were evaluated by biomechani-cal tests, and the effects of Sal B on bone microstruc-ture were evaluated by Safranin O/fast green staining and hematoxylin and eosin staining .The expression of nuclear factor-kappa B ( NF-κB)-p65 and NADPH ox-idase 4 ( Nox4 ) and cathepsin K in femurs was deter-mined by immunohistochemical staining . Results Maximum load and elastic load significantly decreased ,and the trabeculae became thinner and irregular in the femurs of HFD mice , while Sal B treatment could re-verse the descending biomechanical strength and the disorganized femurs bone micro-structures in HFD mice.In addition, the expressions of Nox4, NF-κB-p65 and cathepsin Kmarkedly increased in HFD mice , and Sal B possessed the ability to down-regulate the ex-pression of Nox4, NF-κB-p65, and cathepsin K in the femurs triggered by HFD .Conclusions Sal B treat-ment improves bone metabolism via regulating Nox 4/NF-κB/cathepsin K signaling pathway in HFD mice . The findings contribute to the understanding and exten-sion of the applications of Salvia miltiorrhiza and its constituents on osteoporosis .
ABSTRACT
BACKGROUND: Physiologic Anchorage Spee's-wire System (PASS) is a new appliance for orthodontic treatment in recent years. It has its superiority in support control, torque domination and friction control, and it is also unique in opening bite. OBJECTIVE: To build a three-dimensional finite element model of PASS with intrusion arch, and to analyze its effects on intrusion of the anterior teeth and on enhancing anchorage of the molars.METHODS: The CT scan data were imported into software of Mimicsl7.0 to obtain a three-dimensional model of the teeth and jaw bone. A series of modeling software such as Geomagic Studio, NX, ANSYSl5.0 were used to obtain the three-dimensional model of the maxillary dentition with PASS and intrusion arch. The overall force of the dentition and movement of the anterior teeth were analyzed when the intrusion arch was located at the mesial side of the central incisor and lateral incisor as well as the distal side of the lateral incisor.RESULTS AND CONCLUSION: It was efficient to accomplish the intrusion of the anterior teeth when the arch was located between central incisors. Labial inclination of the anterior teeth was achieved when the arch was ligated at the mesial side of the lateral incisor. Lingual inclination and intrusion of the anterior teeth was found when the arch was located at the distal side of the lateral incisor. Under these three kinds of conditions, the trend of molar retrodisplacement became remarkable. The maximum movement trend of the incisors was achieved, when the arch was ligated at the mesial side of the central incisor, mainly due to the intrusion of the incisors. The molar retrodisplacement was improved under the three conditions. This experiment simulated the stress distribution and displacement trend of the teeth, which is beneficial to the clinical understanding and application of the PASS technology with intrusion arch.
ABSTRACT
BACKGROUND: Physiologic Anchorage Spee's-wire System (PASS) is a new appliance for orthodontic treatment in recent years. It has its superiority in support control, torque domination and friction control, and it is also unique in opening bite. OBJECTIVE: To build a three-dimensional finite element model of PASS with intrusion arch, and to analyze its effects on intrusion of the anterior teeth and on enhancing anchorage of the molars.METHODS: The CT scan data were imported into software of Mimicsl7.0 to obtain a three-dimensional model of the teeth and jaw bone. A series of modeling software such as Geomagic Studio, NX, ANSYSl5.0 were used to obtain the three-dimensional model of the maxillary dentition with PASS and intrusion arch. The overall force of the dentition and movement of the anterior teeth were analyzed when the intrusion arch was located at the mesial side of the central incisor and lateral incisor as well as the distal side of the lateral incisor.RESULTS AND CONCLUSION: It was efficient to accomplish the intrusion of the anterior teeth when the arch was located between central incisors. Labial inclination of the anterior teeth was achieved when the arch was ligated at the mesial side of the lateral incisor. Lingual inclination and intrusion of the anterior teeth was found when the arch was located at the distal side of the lateral incisor. Under these three kinds of conditions, the trend of molar retrodisplacement became remarkable. The maximum movement trend of the incisors was achieved, when the arch was ligated at the mesial side of the central incisor, mainly due to the intrusion of the incisors. The molar retrodisplacement was improved under the three conditions. This experiment simulated the stress distribution and displacement trend of the teeth, which is beneficial to the clinical understanding and application of the PASS technology with intrusion arch.