Clinical Study on Acupoint Iontophoresis with Sinomenine Hydrochloride in Treating Knee Osteoarthritis / 上海针灸杂志

Objective To observe the clinical efficacy of acupoint iontophoresis with Sinomenine hydrochloride in treating knee osteoarthritis (KOA).Method Sixty KOA patients were randomized into a treatment group and a control group, 30 cases each. The treatment group was intervened by iontophoresis with Sinomenine hydrochloride into specific acupoints via a direct current iontophoresis appliance; the control group was intervened by oral administration of Meloxicam tablets. The Lequesne index, Visual Analogue Scale (VAS) and knee joint space were observed before and after the intervention.Result The Lequesne and VAS scores were significantly changed after the treatment in the two groups (P<0.01,P<0.05). After the intervention, there was a significant difference in the Lequesne score between the two groups (P<0.01). After the treatment, the knee joint space didn't show significant intra-group or between- group differences (P>0.05).Conclusion Acupoint iontophoresis with Sinomenine hydrochloride is an effecttive method in treating KOA.

Expression profile of miR-501-5p in lung adenocarcinoma patients from Xuanwei area / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the relationship between miR-501-5p expression and the clinicopathological factors in patients with lung adenocarcinoma in Xuanwei area.</p><p><b>METHODS</b>Surgical specimens of lung adenocarcinoma and paired adjacent tissues from 24 patients with lung adenocarcinoma from Xuanwei area were examined for miR-501-5p expression using microRNA microarray technique and qPCR. Chi-square test was used to analyze the association of miR-501-5P expression with the clinicopathological characteristics of the patients. Multiple regression analysis was performed to analyze the association of miR-501-5p expression with the patients' gender, age, tumor stage, and preoperative CEA level.</p><p><b>RESULTS</b>MicroRNA microarray analysis and qPCR validation results revealed significantly upregulated expressions of miR-501-5p in patients with lung adenocarcinoma from Xuanwei area (Plt;0.01). The microarray data showed an up-regulation of miR-501-5p by 3.17 folds in lung adenocarcinoma tissue compared with the adjacent tissue (P=0.22376, FDR=0.071395). Chi-square test indicated that miR-501-5p expression level was associated with the patients' age (f=7.168, P=0.014), TNM stage (f=36.627, P<0.01), and preoperative serum CEA level (f=30.045, Plt;0.01), but not with the patients' gender (f=3.612, P=0.071). Multiple regression analysis revealed that miR-501-5p expression was positively correlated with the patients' age, TNM stage of the tumor, and serum CEA (Plt;0.05).</p><p><b>CONCLUSION</b>miR-501-5p expression is up-regulated in lung adenocarcinoma with significant associations with the patients' age, TNM stages and serum CEA level in patients from Xuanwei area, suggesting its potential role in the tumorigenesis and progression of lung adenocarcinoma in Xuanwei area.</p>

Specific microRNA expression profiles of lung adenocarcinoma in Xuanwei region and bioinformatic analysis for predicting their target genes and related signaling pathways / 南方医科大学学报

<p><b>OBJECTIVE</b>To identify differentially expressed microRNAs (miRNAs) related to lung adenocarcinoma in Xuanwei region and predict their target genes and related signaling pathways based on bioinformatic analysis.</p><p><b>METHODS</b>High-throughput microarray assay was performed to detect miRNA expression profiles in 34 paired human lung adenocarcinoma and adjacent normal tissues (including 24 cases in Xuanwei region and 10 in other regions). Gene ontology and KEGG pathway analyses were used to predict the target genes and the regulatory signaling pathways.</p><p><b>RESULTS</b>Thirty-four miRNAs were differentially expressed in lung adenocarcinoma tissues in cases in Xuanwei region as compared with cases in other regions, including 23 upregulated and 11 downregulated miRNAs. The predicted target genes included GF, RTK, SOS, IRS1, BCAP, CYTOKINSR, ECM, ITGB, FAK and Gbeta;Y involving the PI3K/Alt, WNT and MAPK pathways.</p><p><b>CONCLUSION</b>The specific microRNA expression profiles of lung adenocarcinoma in cases found in Xuanwei region allow for a better understanding of the pathogenesis of lung adenocarcinoma in Xuanwei. The predicted target genes may involve the PI3K/Alt, WNT and MAPK pathways.</p>

Controlled observation of efficacy on herb-partitioned moxibustion and western medicine in the treatment of persistent and chronic diarrhea of children / 中国针灸

<p><b>OBJECTIVE</b>To evaluate clinical efficacy of herb-partitioned moxibustion with spontaneous heating bag in the treatment of persistent and chronic diarrheal disease (PCDD) of children, and to explore the new treatment protocols for pediatric PCDD.</p><p><b>METHODS</b>One hundred and twenty cases of PCDD were randomly divided into a herb-partitioned moxibustion group (group M) and a western medicine group (group C), 60 cases in each one. The herb-partitioned moxibustion with spontaneous heating bags was given in the group M, which was placed on the herbal cake at Shenque (CV 8) and Guanyuan (CV 4) for 12 hours, once a day. The group C was orally administrated with smectite powder and live combined bifidobacterium and lactobacillus tablets. Plasma motilin (MOT) level and T cell subset CD4+/CD8+ ratio were observed after 10 days of the treatment, also the clinical efficacy was evaluated.</p><p><b>RESULTS</b>The cured rate was 53.3% (32/60) in the group M, which was superior to 40.0% (24/60) in the group C (P < 0.05). After the treatment, MOT levels were both decreased (both P < 0.01) while CD4+/CD8+ ratios were both increased (both P < 0.01) in the two groups. The level of MOT in the group M was lower than that in the group C (P < 0.05).</p><p><b>CONCLUSION</b>The herb-partitioned moxibustion with spontaneous hea-ting bag has better therapeutic effect than routine western medicine on pediatric PCDD, and it has the advantage of easy manipulation, safety and good compliance of children.</p>

Liver transplantation for hepatic metastatic pancreatic insulinoma with a survival over five years / 中华医学杂志(英文版)

Pancreatic neuroendocrine tumors (NETs) are one subgroup of gastroenteropancreatic NETs. Its main characteristics are slow growth, frequent metastasis to the liver, and limited to the liver for long periods. In patients with irresectable liver metastatic NET, liver transplantation is the only radical treatment. About 160 cases of liver transplantation for liver metastatic NET have been reported worldwide. However, there is no such report of liver transplantation for hepatic metastatic NET in China by now. We herein report a case of liver transplantation for hepatic metastatic pancreatic insulinoma with a survival of over 5 years.

Development of three dimensional facial measurement system based on structured light projection / 上海第二医科大学学报

Objective To construct a system for three dimensional face scanning and measurement. Methods The measurement system was based on the principle of triangulation and the combination of gray-code and phase-shift structured light projection. The system software was developed for Windows XP with the aid of tools such as Visual C++ and Hoops. Results A three dimensional measurement system based on structured light projection was developed. The system hardware was composed of fringe projection unit, image gathering unit, system control unit and mechanical appearance, and the system software was composed of point cloud display and editing module. The lamp house of the system was 12V, the working distance was 900 mm, the scanning time was 5.5 s and the scanning field was 500 mm×400 mm. Conclusion The three dimensional measurement system based on structured light projection is a refined machine with safe light to eyes, and the accuracy and scanning speed are suitable to face scanning.

A preliminary study on facial profile reconstruction using structured light three-dimensional scanning technique / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate the feasibility of facial profile reconstruction by use of structured light three-dimensional scanning technique.</p><p><b>METHODS</b>Based on Gray-code and phase-shifting method, the self-developed three-dimensional optical measurement system was used to acquire the primitive point data of a volunteer's face and cast of the face. All the datum records were processed and analysed with Imageware and Geomagic software to reconstruct a three-dimensional face model.</p><p><b>RESULTS</b>Compared with the conventional impression method, the structured light three-dimensional scanning technique reconstructed facial profile with smaller deformation.</p><p><b>CONCLUSIONS</b>Based on Gray-code and phase-shifting method, the self-developed optical measurement system captured three-dimensional facial profile accurately. It would be helpful to the three-dimensional reconstruction of the facial profile defect.</p>

A preliminary study on maxillofacial prosthesis using structured light three-dimensional scanning and rapid prototyping technique / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate application of three-dimensional reconstruction of the facial soft tissue by use of light three-dimensional scanning system and rapid prototyping and to lay a foundation for developing the computer aided design (CAD) and computer aided manufacture (CAM) system of the maxillofacial defect rehabilitation.</p><p><b>METHODS</b>The left and right facial profiles of a volunteer were scanned with the light three-dimensional scanning system that was a self-developed one. The complete point and cloud data were obtained by transforming the image data with the Surfcaq software. Then three-dimensional reconstruction was done via transforming the point and cloud data to Geomagic studio 7.0. The final three-dimensional reconstruction was achieved by way of putting the point and cloud data together with apex nasi, external point of the orbit, mention as the mark points. The image was imported into Magics RP to triangulate and created in the thickness of 2 mm. The three-dimensional resin model was fabricated by fused deposition modeling (FDM).</p><p><b>RESULTS</b>The three-dimensional image of the facial soft tissue of the volunteer was achieved. The three-dimensional resin model of the facial soft tissue of the volunteer was also obtained.</p><p><b>CONCLUSIONS</b>Light three-dimensional scanning system was feasible for three-dimensional reconstruction.</p>

An in vitro study of intraradicular resinifying material removal / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To investigate the associated factors that influence the removal of intraradicular resinifying material.</p><p><b>METHODS</b>One hundred and ninety-seven root canals were treated with resinifying therapy, then the canals were negotiated with sonic, ultrasonic and hand instrument. Those failed to be negotiated were splinted longitudinally and observed with ZOOM-630E stereomicroscope.</p><p><b>RESULTS</b>Sonic and ultrasonic instrument negotiated more canals, especially those with jelly-like resinifying material (76.0% approximately 84.0%) and of smaller curvature (90.0% approximately 100.0%) or larger initial apical file (IAF) size (93.8% approximately 100.0%). Those with hard resinifying material and of bigger curvature or smaller IAF size were hard to be negotiated no matter which kind of instrument was used (0 approximately 20%).</p><p><b>CONCLUSIONS</b>Vibratory instrument can effectively removal intraradicular resinifying material.</p>

Case Report and Literature Review of Hypoparathyroidism-Deafness-Renal Dysplasia Syndrome in Children / 实用儿科临床杂志

Objective To explore the diagnosis and treatment of hypopara thyroidism-deafness-renal dysplasia(HDR) syndrome in children.Methods According to the symptoms,signs,laboratory examination and the previous published papers of other authors,the disease of the child was diagnosed and treated,and some related literatures were reviewed.Results The 12-years-old boy presented with tetany and deafness and Chvostek's and Trousseau's signs were positive.The initial laboratory studies showed that the serum concentration of calcium was lower,parathormone was in the low limit of normal range and alkalin phosphatase was normal.An audiography revealed the pattern of sensorineural deafness in all frequencies.Abdominal CT revealed that his right kidney was not observed and creatinine clearance rate was low.After treated with calcium carbonate and vitamin D,the symptoms and the signs were improved.Conclusion HDR syndrome is a rare disorder and less recognized in children,and therefore more attention should be paid to avoid missing diagnosis.

The regulatory effect of hydrogen sulfide on pulmonary artery prolife rating cell nuclear antigen and Bcl-2 in hypoxic pulmonary hypertensive rats / 实用儿科临床杂志

Objective To explore the regulatory effects of hyd ro gen sulfide (H 2S) on hypoxic pulmonary hypertension and pulmonary vascular rem odeling in rats. Methods Twenty-four rats were divided into 3 groups: control group(n=8), hypoxia group(n=8), and hypoxia +NaHS group( n=8). After 21 days of hypoxia, the mean pulmonary artery pressure (mPAP) wa s measured. The weight ratio of right ventricle. left ventricle +septum (R/L+S r atio) was measured. The microstructure and ultrastrcture changes in pulmonary sm all arteries were examined. The contents of proliferating cell nuclear antigen (PCNA) and Bc l-2 protein expressions were detected by immunohistochemical assay.Resu lts Compared with rats in the control group, the mPAP increased by 45.6 % (P

Multiple Organic Damages in 202 Cases with Kawasaki Disease / 实用儿科临床杂志

Objective To analyze the clinical features of organic damages in Kawasaki disease(KD),and to improve the diagnosis and treatment level.Methods Two hundred and two cases with KD admitted in Children's Hospital Affiliated to Capital Institute of Pediatrics from Jan.2000 to Oct.2007 were reviewed,and their blood routine,urine,stool routine,liver function,kidney function,chest X-ray,and so on,were investigated.The incidence of organic damages in KD was evaluated.Results Among the 202 KD children,137 were male and 65 were female,the male-female ratio was 2.11.0.Most of them were infants,and 71.3% of them were younger than 3 years old.The damages of hematological system were detected in 78/202 cases(38.6%),respiratory system 76/202 cases(37.6%),cardiovascalar system 68/202 cases(33.7%),urinary system 52/202 cases(25.6%),digestive system 23/202 cases(11.4%),and central nervous system 3/202 cases(1.5%).On the other hand,3 cases complicated with septemia,1 case with juvenile rheumatoid arthritis and 1 case with Henoch-Schonlein purpura.Conclusions The data indicate that the incidence of hematological system involvement in the sick-children with KD were highest,with more than 2 organs involved simaltaneously.Many organic damages were involved in KD and diverse clinical manifestation could be found.Physicians should understand not only the typical features but also the rare symptoms and organic damage so as to prevent misdiagnosis and improper treatment.J Appl Clin Pediatr,2009,24(1):31-32