ABSTRACT
Objective To explore the differential expression of CD269 and CD317 in patients with multiple myeloma(MM). Methods Newly diagnosed samles from patients of MM(20 cases)and iron deficiency anemia(20 cases),40 cases in total (from 06/2015 to 08/2013,the Department of Hematology,Central Hospital of Zhuzhou City)were collected.Real-time quantitative PCR(RQ-PCR)tests were used to detect the relative expression of CD269 and CD317 in bone marrow sam-ples,and the results were statistically analyzed with clinical features.Results The relative expression levels of CD269 and CD317 in patients with multiple myeloma(4.418±4.568,4.327±2.876)were significantly higher than those in the control group(0.600±0.838,1.033±1.335),the difference was statistically significant(t=3.676,4.646,all P<0.05)respective-ly,while not related with the gender,age(P>0.05).There was no correlation between the expression of CD269 and CD317 (r=0.041,P=0.864),but positively correlated with the ratio of myeloma cells(r=0.495,P=0.026;r=0.533,P=0.016).Conclusion CD269 and CD317 were highly expressed in patients with multiple myeloma and may be involved in the pathogenesis of multiple myeloma.
ABSTRACT
Mycoplasma pneumonia is one of the important pathogens leading to respiratory tract infection.Recently,the incidence of M.pneumoniae infection increased rapidly,which contributes about 30％ of lung disease in children.The early clinical symptoms for M.pneumoniae infection is not typical,which is not sensitive to antibiotics acting on cell walls.Therefore,early laboratory detection of M.pneumoniae is very important for later treatment.Herein,this paper aims to sum up the recent development progress of M.pneumoniae detection.
ABSTRACT
Mycoplasma pneumonia is one of the important pathogens leading to respiratory tract infection.Recently,the incidence of M.pneumoniae infection increased rapidly,which contributes about 30％ of lung disease in children.The early clinical symptoms for M.pneumoniae infection is not typical,which is not sensitive to antibiotics acting on cell walls.Therefore,early laboratory detection of M.pneumoniae is very important for later treatment.Herein,this paper aims to sum up the recent development progress of M.pneumoniae detection.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical efficacy of the pith decompression of the femoral head and fibular allograft transplantation in the treatment of early stage avascular necrosis.</p><p><b>METHODS</b>From January 2004 to November 2008, 32 hips of 25 patients with avascular necrosis of femoral head of Ia-IIIb period were treated by the pith decompression of the femoral head and fibular allograft transplantation, hollow lag screw fixation, included 17 males and 8 females, aged from 20 to 55 years old (39.1 years on average). Preoperative pain was from 2 to 14 months (means 5.5 months). All patients were applied on conventional X-ray films, MRI examination, Harris score.</p><p><b>RESULTS</b>The patients were followed up for 12 to 48 months (means 36.4 months). X-ray film showed 21 hips of 18 cases improved,6 hips of 4 cases unchanged, no collapse of articular surface, 3 hips of 2 cases deterioration, 2 hips of 1 case failed. Preoperative Harris score was (77.0 +/- 8.0) and postoperative (90.6 +/- 2.5), there was a significant difference (t = 1.67, P < 0.05).</p><p><b>CONCLUSION</b>Pith decompression of the femoral head and fibular allograft transplantation in the treatment of early stage avascular necrosis of femoral head has advantage of joint function in bed-ridden after a short time, quick recovery,clinical symptoms improved. Its short-term efficacy is certain but long-term efficacy is still need further observation.</p>