ABSTRACT
Objective Castleman's disease(CD)is a rare lymphoproliferative disorder characterized by various clinical mani-festations and pathological features .The study was to improve the recognition of Castleman's disease by summarizing its clinicopatholog-ic features. Methods A retrospective analysis was conducted on the clinical data , histopathological changes , treatment and progno-sis of 20 CD patients admitted in Jinling Hospital , Nanjing University School of Medicine from February 2010 to April 2017. Results Among the 20 CD patients, there were 11 males and 9 females, the median age was 41.5 (14~73) years, 9 cases were unicentric Cas-tleman's disease ( UCD) and 11 cases multicentric Castleman's disease ( MCD) .UCD tended to be found by physical examination or local palpable masses , characterized by enlarged lymph nodes with hyaline-vascular type in pathological form , treated mainly by resec-tion with favorable prognosis .MCD frequently appeared with constitutional symptoms and multiple system involvement , such as fever , edema, hyperglobulinemia and increasing CRP level , mostly presenting plasma cell type in pathological form with poor prognosis being mainly treated by comprehensive therapy . Conclusion The diagnosis of CD mainly depends on pathological examination .UCD ap-pears mild clinical features with favorable prognosis after surgery , while MCD is characterized by complex clinicial manifestation and should be treated by comprehensive therapy which results in poor prognosis .