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Medical Forum Monthly. 2014; 25 (1): 2-5
in English | IMEMR | ID: emr-161253


To investigate the protective effect of Curcuma longa [CL] against carbon tetrachloride [CC1[4]] induced liver injury in adult male Wistar rat model. Study Experimental/Analytical study Place and Duration of Study: Animal House, Isra University Hyderabad from March to December 2013. Forty five adult male Wistar rats were divided into three groups; Group 1. controls received 0.9% isotonic saline, Group 2. received CC1[4] orally [1.9mg/kg] mixed in olive oil, and Group 3. received the CC1[4]+CL [250mg/kg] Blood samples were collected for liver biochemical assays. The animals were sacrificed, liver tissue, after fixation in 4% formaldehyde, was embedded in paraffin. Tissue sections of 5 micro thickness were subjected to haematoxylin and eosin staining and were assessed by light microscopy. The data was analyzed on SPSS 21.0 using one-way ANOVA, Fischer's LSD and Chi-square tests. A p-value of

Medical Forum Monthly. 2014; 25 (1): 76-79
in English | IMEMR | ID: emr-161270


To investigate the effects of orally administered monosodium glutamate [MSG] on the fallopian tube histology in adult female Wistar rat model. Experimental/Analytical study. Animal House, Isra University Hyderabad from May to November 2013. Forty adult male Wistar rats were divided into three groups; Group A. controls received 0.9% isotonic saline, Group B. received MSG orally [1.5 mg/kg], and Group C. received MSG orally [3 mg/kg]. The animals were sacrificed after six weeks. Fallopian tubes were fixed in 4% formaldehyde, and were embedded in paraffin. Tissue sections of 5micro thicknesses were subjected to haematoxylin and eosin staining and were assessed by light microscopy. The fallopian tubes [FT] of the control group A showed normal histological features. The fallopian tubes of the treated groups showed some cellular hypertrophy of the columnar epithelium, distortion of the basement membrane separating the endosalpinx from the myosalpinx. There were degenerative and atrophic changes observed in some parts; these were more pronounced in those that received 3 mg/kg body weight of MSG. There were marked vacuolations and lysed red blood cells, [3 mg/kg body weight treated rats] appearing in the stroma cells. The monosodium glutamate may have deleterious effects on the fallopian tube histology in adult female Wistar rats particularly in high dose. Therefore caution must be taken for its frequent use in female because of possibility of female infertility

Medical Forum Monthly. 2014; 25 (6): 22-25
in English | IMEMR | ID: emr-153157


To assess the frequency of common thyroid cancer at king Fahad Hospital, Madinah. Retrospective study. This study was carried out on all the patients treated for Cancer of Thyroid Gland, at King Fahad Hospital [KFH]-Madinah between Jan 2009 to February 2012. Ninety-one patients diagnosed with Cancer of Thyroid of various Age, Sex and Races were registered with King Fahad Hospital Madinah. 75% patients were Saudi nationals, 10% patients were from other Arab countries and the remaining 15% were non-Arabs. There were 72% females and 28% Males. The Ages ranged from 14 years to 94 years. 34% of these patients were less then 30 years of Age at the time of the diagnosis. Over 90% of the cases presented with Swelling Anterior Neck while in other 10% of the cases Dysphagia or Dyspnoea with Rt. or Lt. supraclavicular masss/swelling was the major complaint. 71% patients under went various surgical procedures for the Neck swelling. The Total Thyroidectomy was done in 48% patients. The Histology revealed 52% of pure Papillary Carcinoma and 23% were of Follicular origin. Majority of the diagnosed patients of Ca. Thyroid were referred to King Faisal Specialist Hospital Riyadh for Radioactive Iodine Ablation Therapy. The follow-up was poor as patients were from highly mobile population and belonged to Nine different countries. The study reveals that the presentation of Ca. Thyroid in our series is essentially similar to what has been reported from other parts of the world

Isra Medical Journal. 2014; 6 (1): 19-21
in English | IMEMR | ID: emr-183469


Objectives: To determine the supportive role of magnesium sulfate in the management of acute sthmatic patients

Study design: A descriptive comparative study

Place and duration: The Study was conducted from January 2010 to June 2010 at Department of Medicine, Isra University Hospital, Hyderabad, Liaquat University Hospital, Hyderabad and Institute of Chest Diseases, Kotri, Sindh

Methodology: Acute asthmatic patients between ages of 10 to 40 years reporting to emergency department were enrolled in the study. They were divided into two groups. Groups I patients [n = 36] received oxygen inhalation, nebulization by ventoline and intravenous hydrocortisone. Group II patients [n = 37] received oxygen, ventoline nebulization, intravenous hydrocortisone and IV magnesium sulfate 25 ml /kg body weigh diluted in 100 ml of normal saline delivered over a period of 30 minutes

Results: Seventy three patients were included in this study. Baseline parameters were compared in the two groups. Both group showed significant improvement in pulse rate which was 90.9 +/- 8.46 in group I [without magnesium] and 82.3 +/- 5.11 beat per minute in group II [with magnesium]. Oxygen saturation after 120 minute was 95.9 +/- 2.02 and 96.2 +/- 1.5% in group I and group II, respectively. Similarly, after 120 minutes, PEFR was 205 L/minute in group I as compared to 237 L/minute in group II

Conclusion: This study suggested that there was benefit of adding IV magnesium sulfate to ventoline nebulization and intravenous hydrocortisone in the treatment of severe or life threatening asthma

Annals Abbassi Shaheed Hospital and Karachi Medical and Dental College. 2011; 16 (1): 52-56
in English | IMEMR | ID: emr-127759


To study the effect of ketoconazole induced liver damage, compare with control group and correlate with previous studies. Experimental study conducted during year 2005 in the Department of Anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre,Karachi. Forty adult male albino rates were used for this study. Group-A served as control animals, received injection of normal saline in dose of 0.05 ml/100 gm of body weight inraperitoneally daily for 03, 07, 05 and 30 days. Group-B received injection of ketoconazole 40 mg/kg of body weigh intraperitoneally daily for 03, 07, 15 and 30 days of treatment. Animals were sacrificed after completion of treatment under ether anaesthesia. Liver were removed, fixed in 10% and alcoholic formalin for 24-48 hours. They were dehydrated in ascending strength of alcohol and paraffin tissue blocks were made 5 microm thick section were stained with HandE for general morphology and micrometry and the result were compared with control. Analyzed satistically with student 't' test and correlate with previous studies. Ketoconazole treated animals showed distortion of hepatic architecture increase size of hepatocytes, decrease nuclear diameter and necrosis of hepatocytes within hepatic lobule as compared to control group-A animals. It was sconcluded from this study that ketoconazole induced injury is dose and duration of therapy dependent and due to its cost effective frequent use needs further research in humans

Annals Abbassi Shaheed Hospital and Karachi Medical and Dental College. 2010; 15 (1): 20-25
in English | IMEMR | ID: emr-117865


To observe the morphological and histochemical findings, produced by piroxicam and zinc in mice liver and correlate with serum hepatic enzyme. For this experimental study 30 adult mice [25 -30 grams] were obtained from animal house of Jinnah Postgraduate Medical Center, and divided into three groups i.e. A, B and C. Group A served as control and received normal diet, Group B received piroxicam 0.3 mg /Kg body weight intraperitoneally and Group C 1mg/Kg body weight of zinc intraperitoneally and piroxicam in the same dose as group B. After completion of study [6 weeks] animals were scarified and their livers were removed and after processing paraffin section were made and stained with Haematoxylin and Eosin for histological and histochemical examinations and correlate with serum hepatic enzyme level. Haematoxylin and Eosin stained section of group A indicated the normal histology and morphometry, the group B showed distorted hepatic lobular architecture. Central vein and sinusoids was dilated and congested, kupfer cell prominent and pyknotic cells and mono nuclear infiltration were seen. Group C showed altered histological findings comparable to group A. The Histochemical findings of group B showed depletion in glycogen content marked fibrosis of reticulin fibres and increased deposition of calcium phosphate crystals. In group C effect of zinc improve glycogen content and reticulin fiber deposition and decreased deposition of alkaline phosphatase crystals. The serum enzyme level of Alkaline Phosphatase and Serum Gulutamin Phosphatase significantly increased in group B animals and less significantly increase in group C as compared to group B animals. It was concluded that piroxicam in therapeutic dose, was toxic and produced hepatic injury and zinc along with piroxicam improved the hepatic damage

Animals, Laboratory , Piroxicam/toxicity , Piroxicam/adverse effects , Zinc/pathology , Mice