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Ann Natl Acad Med Sci ; 2019 Jan; 55(1): 48-53
Article | IMSEAR | ID: sea-189735


This study compared hemodynamic changes and occurrence of complications following oxytocin administration with a prior injection of phenylephrine 100 μg or normal saline during elective cesarean section. Sixty-six healthy term parturients with uncomplicated, singleton pregnancy undergoing elective cesarean section under spinal anesthesia were studied. They received either intravenous phenylephrine 100 μg or normal saline before oxytocin 3 IU was administered over 30 seconds. Oxytocin dose was repeated depending on the adequacy of uterine tone. There was no significant change in systolic, diastolic, and mean arterial pressures during the initial 3 minutes following oxytocin administration in the phenylephrine group but a significant fall in mean and diastolic pressures in the saline group. Heart rate did not change significantly, and no significant complications occurred in either of the groups. To conclude, phenylephrine 100 µg administered before oxytocin injection maintained hemodynamic parameters better than normal saline injection during elective cesarean section

Indian J Pathol Microbiol ; 2013 Apr-Jun 56 (2): 155-157
Article in English | IMSEAR | ID: sea-155853


Genital tuberculosis is an important under-diagnosed factor of infertility. A vast majority of cases are asymptomatic and diagnosing them will help in treating such patients. We conducted a retrospective study in a tertiary care hospital of Delhi with an aim to compare different methods i.e., histopathological examination (HPE), acid-fast bacilli (AFB) smears, Lowenstein-Jensen (LJ) culture, BACTEC culture and polymerase chain reaction deoxyribonucleic acid (PCR-DNA) for diagnosing endometrial tuberculosis in infertile women. The data from 546 samples of endometrial biopsy histopathology, AFB smears and LJ culture was collected and then analyzed. Of these, HPE for tuberculosis was positive in 13, LJ culture in 10, AFB smear was positive in one case. BACTEC and PCR-DNA were feasible for 90 patients and PCR-DNA was positive in 20 and BACTEC in eight patients. Out of 20 patients with PCR positive results, 15 were only PCR positive and were subjected to hyster-laparoscopy and fi ve had evidence of tuberculosis. Thus, none of the available tests can pick up all cases of genital tuberculosis, but conventional methods i.e., histopathology and LJ culture still has an important role in the diagnosis of endometrial tuberculosis in government setups where BACTEC and PCR are not performed routinely due to lack of resources.

Article in English | IMSEAR | ID: sea-171278


This is a case of spontaneous intracerebral hemorrhage of unknown etiology presenting in the third trimester for which lifesaving intracranial surgery was undertaken along with simultaneous caesarian section to avoid risk of deep anesthesia and fetal morbidity.

Indian J Pathol Microbiol ; 2005 Apr; 48(2): 225-7
Article in English | IMSEAR | ID: sea-73930


Partial mole is a gestational neoplastic disorder with a reported incidence of 0.005 - 0.01% of all pregnancies. The karyotype in such cases is usually triploid, baring a few exceptions. The diploid partial mole is an extremely rare entity with only few cases being documented in literature. The fetal outcome in such cases is usually poor. We describe a case of partial mole, which terminated at 28 weeks with a live diploid male fetus with good neonatal outcome. Follow-up showed no progression to malignant gestational trophoblastic disease.

Adult , Diploidy , Female , Fetal Viability , Humans , Hydatidiform Mole/pathology , Infant, Newborn , Infant, Premature , Male , Pregnancy , Pregnancy Complications, Neoplastic/pathology , Uterine Neoplasms/pathology
Indian J Exp Biol ; 2003 Apr; 41(4): 290-5
Article in English | IMSEAR | ID: sea-62367


Mouse peritoneal macrophages (MPM) when elicited by the antioxidant ascorbic acid have been found to be significantly stimulatory, exhibiting marked alteration at the cellular and enzyme levels. Alterations recorded were as follows--cellular yield per mouse, their protein content, lysosomal acid hydrolase levels and capability to phagocyte, all were significantly enhanced. The new stimulant was observed to produce no synergistic action on MPM when thioglycollate, BCG or endotoxin along with the same stimulated the latter. Levels of antioxidants like ascorbic acid and glutathione were found to be enhanced in elicited macrophages whereas superoxide dismutase levels varied when the three above stimulators were administered. However, the ascorbic acid elicited cells showed an increase in glutathione levels and a decrease in SOD levels but no change in total intracellular ascorbic acid levels. Further, though ascorbic acid interaction enhanced the phagocytic capability of MPM as compared to resident cells, no significant boosting of phagocytic process could be observed when each of three stimulators coupled with ascorbic acid was used for macrophage elicitation.

Animals , Antioxidants/pharmacology , Ascorbic Acid/pharmacology , Endotoxins/pharmacology , Glutathione/metabolism , Hydrolases/metabolism , Lysosomes/enzymology , Macrophages, Peritoneal/drug effects , Mice , Mice, Inbred BALB C , Mycobacterium bovis/metabolism , Phagocytosis/drug effects , Superoxide Dismutase/metabolism , Thioglycolates/pharmacology