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Article in Chinese | WPRIM | ID: wpr-847727


BACKGROUND: Dentin particles, tricalcium phosphate/collagen protein composites and Bio-oss particles can repair jaw defects, but the excellent osteogenic effect is not clear. OBJECTIVE: To compare osteogenic effects of three different bone graft materials on mandibular defects in beagle dogs. METHODS: Eight 1-year-old beagles were selected. A boxed bone defect area of 10 mm × 8 mm × 2 mm was prepared at the bilateral mandibular external oblique line and randomly divided into four groups with four bone defect models in each group. Undemineralized dentin particles were implanted in group A; tricalcium phosphate/ collagen protein composite materials were implanted in group B; Bio-oss particles were implanted in group C; and group D was used as blank control. Three months after transplantation, the samples were taken for histological observation. The experimental animals were approved by the Ethics Committee of the Experimental Animal Center of Dalian Medical University. RESULTS AND CONCLUSION: (1) In group A, dentin particles were slightly absorbed, surrounded by new bone tissue; new bone trabeculae and capillaries could be seen, and a large number of fibrous connective tissue surrounded dentin particles in the central area of bone graft. In group B, a small number of new bone trabeculae and osteoblasts could be seen; a large number of powdered β-tricalcium phosphate particles and a small amount of inflammatory cells could be seen in the fibrous connective tissue; and some β-tricalcium phosphate particles were surrounded by new bone tissue. Bone marrow cavity could be seen in the new bone. In group C, some Bio-oss particles were surrounded by new bone tissue; some Bio-oss particles were wrapped by surrounding fibrous connective tissue, and fibers, particles and new bone were intertwined. There was no new bone formation in group D, and many capillaries could be seen in a large number of fibrous connective tissue. (2) The rate of new bone formation in groups A, B and C was higher than that in group D (P < 0.05); the rate in groups A and C was higher than that in group B (P < 0.05). (3) The results show that all the three kinds of bone graft materials can promote the formation of new bone. The short-term osteogenic effects of undecalcified xenogeneic dentin particles and Bio-oss particles are better than tricalcium phosphate/collagen protein composites, but the long-term effects need to be further observed.

Modern Hospital ; (6): 684-687, 2018.
Article in Chinese | WPRIM | ID: wpr-698899


Objective To explore the effect of hospital-community integration follow-up pattern on medication compliance in patients with mental disorder. Methods From January 2016 to January 2017, 96 patients were treated effectively with systemic therapy in psychosomatic department and TCM WM department, and 96 discharged mental disorder patients were treated with brief psychiatric rating scale (BPRS) ≤ 28. The patients were randomly divided into 48 cases in the intervention group and the control group; both groups were standardized medication; control group received an outpatient referral, intervention group combined with medical doctors in our hospital and community doctors for one year follow-up intervention. Observed the condition of illness and medication compliance after six months and one year intervention between two groups, compared the patient recurrence rate of one year after discharge. Results BPRS score of intervention group was significantly lower than control group (P<0. 01), the difference was statistically significant, while intervention group had higher compliance than control group (P<0. 01), and the difference was statistically significant. Recurrence rate (20. 83%) of intervention group was significantly lower than control group (38. 78%) ( 2 = 4. 03, P<0. 05), the difference was statistically significant. Conclusion Hospital-community integration follow-up has positive effect on stabilizing patients with mental disorder and improving compliance and decreasing relapse rate.

Clinical Medicine of China ; (12): 8-10, 2014.
Article in Chinese | WPRIM | ID: wpr-456723


Objective To investiGate the constituent ratio of etioloGy,complications and tumor occurrence of maintenance hemodialysis patients. Methods Obseved the patients with maintenance hemodialysis in ZhonGshan Hospital Affiliated to Dalian University in 20l3. The patientsˊ aGe,Gender, protopathy,and other basic information includinG statistics complication and tumor occurrence rate were surveyed. Results There was same ratio of male and female in 222 cases. The primary disease of diabetic nephropathy accounted for 30. 2%( 67 cases ),hypeertensive nephropathy 2l. 2%( 47 cases ),chronic Glomerulonephritis l8. 0%(40 cases),polycystic kidney 6. 8%(l5 cases),obstructiverenal injury accounted for 5. 4%(l2 cases)and other diseases. HemoGlobin of 73 cases(32. 0%)reached the tarGet value(lll G/L) . There was 55. 2% of patients ( l23 cases ) experienced calcium and phosphorus metabolism disorder. Parathyroid hormone levels of 47. 4% patients( l47 cases ) were hiGher than normal. The tumor incidence was 7. 6%( l7/222 ). Conclusion The major primary disease of the patients with maintenance hemodialysis are diabetic nephropathy,hypertension nephropathy and chronic Glomerulonephritis. The level of hemoGlobin,calcium and phosphorus metabolism disorder and parathyroid hormone are low. There is hiGh incidence of tumor.