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Biomedical and Environmental Sciences ; (12): 459-462, 2018.
Article in English | WPRIM | ID: wpr-690635


A retrospective analysis was performed in two major HIV/AIDS referral hospitals in Beijing to evaluate the prevalence of Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections in HIV-infected patients. A total of 627 patients' data were reviewed, and 102 (16.3%) patients were diagnosed with culture-confirmed mycobacterial infection, including 84 with MTB, 16 with NTM, and 2 with both MTB and NTM. The most frequent clinical complication by mycobacterial infection was pulmonary infection (48/102, 47.1%). The overall rates of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) were 11.9% and 3.4%, respectively. This study underlines the urgent need to intensify screening for mycobacteria coinfection with HIV and to prevent the spread of drug-resistant TB among HIV-infected patients.

Adult , Female , Humans , Male , AIDS-Related Opportunistic Infections , Epidemiology , Microbiology , Beijing , Coinfection , Extensively Drug-Resistant Tuberculosis , Epidemiology , Microbiology , HIV Infections , Epidemiology , Microbiology , Hospitals, Urban , Mycobacterium Infections, Nontuberculous , Epidemiology , Microbiology , Mycobacterium tuberculosis , Nontuberculous Mycobacteria , Prevalence , Retrospective Studies , Sputum , Microbiology , Tuberculosis, Multidrug-Resistant , Epidemiology , Microbiology , Tuberculosis, Pulmonary , Epidemiology , Microbiology
Biomedical and Environmental Sciences ; (12): 222-226, 2015.
Article in English | WPRIM | ID: wpr-264596


70 clinical Mycobacterium tuberculosis strains isolated from AIDS patients in two HIV/AIDS referral hospitals in Beijing were used in this study. M. tuberculosis and non-tuberculosis mycobacterium (NTM) were identified by using multi-locus PCR. M. tuberculosis was genotyped by using 15-locus MIRU-VNTR technique and spoligotyping afterwards. Meanwhile, the drug susceptibilities of the strains to the four first-line anti TB drugs (rifampin, isoniazid, streptomycin, and ethambutol) and the four second-line anti-TB drugs (capreomycin, kanamycin, ofloxacin, and ethionanide) were tested with proportional method. In this study, M. tuberculosis and NTM strains isolated from AIDS patients with TB-like symptoms were identified and genotyping analysis indicated that Beijing genotype was the predominant genotype. In addition, the prevalence of drug-resistant TB, especially the prevalence of XDR-TB, was higher than that in TB patients without HIV infection.

Humans , AIDS-Related Opportunistic Infections , Microbiology , Antitubercular Agents , Pharmacology , China , Microbial Sensitivity Tests , Mycobacterium tuberculosis , Classification , Phylogeny , Tuberculosis , Microbiology