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Mem. Inst. Oswaldo Cruz ; 108(3): 392-394, maio 2013.
Article in English | LILACS | ID: lil-676978

ABSTRACT

The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.


Subject(s)
Humans , Antiviral Agents/pharmacology , Drug Resistance, Viral/genetics , Influenza A Virus, H1N1 Subtype/drug effects , Mutation , Neuraminidase/genetics , Oseltamivir/pharmacology , Brazil , Influenza A Virus, H1N1 Subtype/enzymology , Influenza A Virus, H1N1 Subtype/genetics , Microbial Sensitivity Tests , Reverse Transcriptase Polymerase Chain Reaction , RNA, Viral/genetics
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