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Braz. j. med. biol. res ; 56: e12671, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1430017


In biliary atresia (BA), efforts to prevent premature liver transplantation (LT) are aimed at early diagnosis, timing of Kasai-portoenterostomy (KPE), and centralization of care. This report presents the clinical picture, treatment strategies, and outcomes of BA patients with no previous treatment. A retrospective cohort study (Jan/2001 to Jan/2021) was conducted to evaluate the outcome of patients with BA referred to a single team. Study groups were: 1) Kasai-only group (K-only) n=9), 2) LT-only group (n=7), and 3) Kasai+LT group (K+LT) (n=23). Survival with native liver and overall survival were 22.9 and 94.8%, respectively, at 120 months of follow-up. There was no difference in age at KPE in the K-only group (46.8±21.8 days) vs K+LT (52.1±22 days), P=0.4. Ten (25.6%) patients were babies conceived through in vitro fertilization (IVF). Four IVF patients (40%) presented associated congenital heart disease vs 5 patients (17%) in the remaining group (P=0.14). Two of the IVF patients were premature (<37 weeks). Median maternal age at birth was 35 years (33 to 41 years). Excellent patient survival is expected for patients with BA with the available treatment strategies. IVF+BA was an unexpected prevalent association in this cohort, and further studies are required to better understand these findings.

Article in English | LILACS | ID: biblio-1354807


ABSTRACT: The authors report the case of a veterinarian who acquired brucellosis infection by accidental exposure to Brucella abortus vaccine (BRUCEL-VET B19) while performing animal vaccination. Antibiotic prophylaxis with doxycycline and rifampin for six weeks was indicated, but rifampin was discontinued after 10 days due to gastrointestinal in-tolerance. Despite prophylaxis, the patient seroconverted after 30 days, but was asymptomatic and did not require additional antibiotic therapy. Post-exposure prophylaxis of Brucella is not free from side effects and asymptomatic seroconversion can occur despite prophylaxis. (AU)

RESUMO: Os autores relatam o caso de um veterinário que adquiriu infecção por brucelose por exposição acidental à vacina Brucellaabortus (BRUCEL-VET B19) durante a vacinação animal. A profilaxia antibiótica com doxiciclina e rifampici-na por seis semanas foi indicada, mas a rifampicina foi descontinuada após 10 dias devido à intolerância gastroin-testinal. A profilaxia pós-exposição de Brucella não está isenta de efeitos colaterais e a soroconversãoassintomática pode ocorrer apesar da profilaxia. (AU)

Humans , Male , Adult , Brucellosis , Occupational Exposure , Vaccination , Veterinarians , Post-Exposure Prophylaxis , Anti-Bacterial Agents
Arq. bras. med. vet. zootec. (Online) ; 73(3): 658-664, May-June 2021. tab
Article in English | LILACS, VETINDEX | ID: biblio-1278358


Most sandy soils have low natural fertility and low levels of organic matter, making nitrogen (N) fertilization essential. Thus, five doses of N were applied (0, 75, 125, 175 and 225mg dm-³) in a randomized block design to evaluate the effects of nitrogen fertilization on the morphogenetic, structural and production characteristics of Brachiaria brizantha cv. Marandu in a Quartzarenic neosoil. The doses of N did not affect the height of the canopy. The leaf elongation rate, final leaf length and number of live leaves increased linearly at the doses of N. Leaf appearance rate, stem elongation rate, leaf lifespan, phyllochron, leaf senescence rate and tiller density showed a quadratic response to the rates There was also an effect of N rates in herbage mass, leaf mass, stem mass, which increased linearly. Brachiaria brizantha cv. Marandu cultivated in Quartzarenic neosoil requires higher doses of N, 175 and 225mg dm-³. Under these conditions, increases in its morphogenetic, structural and productive characteristics are observed. These findings may not be repeated in the most fertile soils with the greatest capacity to supply N.(AU)

A maioria dos solos arenosos tem baixa fertilidade natural e baixos teores de matéria orgânica, tornando a adubação com nitrogênio (N) essencial. Assim, foram aplicadas cinco doses de N (0, 75, 125, 175 e 225mg dm-³) em delineamento de blocos ao acaso, para se avaliarem os efeitos da adubação com nitrogênio nas características morfogênicas, estruturais e produtivas da Brachiaria brizantha cv. Marandu, em um Neossolo Quartzarênico. As doses de N não afetaram a altura do dossel. A taxa de alongamento foliar, o comprimento final da folha e o número de folhas vivas aumentaram linearmente em função das doses de N. A taxa de aparecimento de folhas, a taxa de alongamento do caule, o tempo de vida da folha, o filocrono, a taxa de senescência foliar e a densidade de perfilhos apresentaram resposta quadrática às doses de N. A massa da forragem, a massa foliar e a massa do caule aumentaram linearmente. Brachiaria brizantha cv. Marandu cultivada em Neossolo Quartzarênico requer maiores doses de N, 175 e 225mg dm-³. Nessas condições, são observados aumentos em suas características morfogenéticas, estruturais e produtivas. Esses achados podem não se repetir nos solos mais férteis e com maior capacidade de suprir N.(AU)

Urea , Brachiaria/anatomy & histology , Brachiaria/chemistry , Soil Characteristics/analysis , Composting
Arq. bras. med. vet. zootec. (Online) ; 71(6): 1765-1772, Nov.-Dec. 2019. tab
Article in English | LILACS, VETINDEX | ID: biblio-1055152


The present study aimed to evaluate the effects of the transition period on hematological and biochemical constituents in Mangalarga Marchador mares. Forty-eight mares were used to form a maintenance group (MG) and transition group (TG), formed by pregnant mares and, after delivery, infants. Blood samples were collected at the following times: T-60 (60 d pre-delivery), T-30 (30 d pre-delivery), T-15 (15 d pre-delivery), T0 (first 6h post-delivery), T15 (15 d post-delivery), T30 (30 d post-delivery), and T60 (60 d post-delivery). The TG had lower values (P< 0.05) of red blood cells, hematocrit and hemoglobin at T0, T15, T30 and T60 times than MG. The mean corpuscular volume was lower in MG (P< 0.05) than in TG (T0, T15, T30 and T60) and mean corpuscular hemoglobin concentration was higher (P< 0.05) in MG than in TG (T15, T30 and T60). On the other hand, the diameter distribution of red blood cells presented a lower value (P< 0.05) in MG than in TG (T15 and T30). Mares in transition period presented regenerative anemia. The results demonstrate physiological metabolic variations of different intensities during pregnancy, delivery and early lactation.(AU)

O presente estudo teve como objetivo avaliar os efeitos do período de transição em constituintes hematológicos e bioquímicos em éguas Mangalarga Marchador. Foram utilizadas 48 éguas para formar um grupo de manutenção (GM) e um grupo de transição (GT), composto por éguas gestantes e, após o parto, lactentes. Amostras de sangue foram coletadas nos seguintes tempos: T-60 (60 dias pré-parto), T-30 (30 dias pré-parto), T-15 (15 dias pré-parto), T0 (seis primeiras horas pós-parto), T15 (15 dias pós-parto), T30 (30 dias pós-parto) e T60 (60 dias pós-parto). O GT apresentou valores menores (P<0,05) de hemácias, hematócrito e hemoglobina, nos tempos T0, T15, T30 e T60, do que o GM. O volume corpuscular médio foi menor no GM (P<0,05) do que no GT (T0, T15, T30, T60) e a concentração corpórea de hemoglobina corpórea foi maior (P<0,05) no GM do que no GT (T15, T30, T60). Por outro lado, a distribuição do diâmetro dos eritrócitos apresentou um valor menor (P<0,05) no GM do que no GT (T15 e T30). Éguas em período de transição apresentam anemia regenerativa. Os resultados demonstram variações metabólicas de diferentes intensidades durante a gestação, o parto e o início de lactação.(AU)

Animals , Female , Pregnancy , Lactation , Peripartum Period/blood , Horses/blood , Blood Cell Count/veterinary
Arq. bras. med. vet. zootec. (Online) ; 71(2): 404-410, mar.-abr. 2019. tab
Article in English | VETINDEX, LILACS | ID: biblio-1011287


The present study assessed and compared the effects of hypotonic enteral electrolyte solutions administered by nasoesophageal tube in continuous flow in dogs submitted to water restriction on packed cell volume; total serum protein and serum osmolarity concentrations; blood volume; plasma glucose and lactate levels; blood gas analysis, anion gap, and strong ion difference. Six adult dogs were used (four males and two females). All animals were submitted to both proposed treatments in a crossover design 6×2. The treatments were as follows: ESmalt consisting of 5g sodium chloride, 1g potassium chloride, 1g calcium acetate, 0.2g magnesium pidolate, and 9.6g maltodextrin that were diluted in 1.000mL water (measured osmotic concentration of 215mOsm L−1) and ESdext consisting of 5g sodium chloride, 1g potassium chloride, 1g calcium acetate, 0.2g magnesium pidolate, and 9.6g dextrose that were diluted in 1.000mL water (measured osmotic concentration of 243mOsm L−1). All solutions were administered at 15ml kg−1 h−1 for 4 hours. Both solutions increased the plasma volume in dehydrated dogs without causing adverse effects. However, ESmalt was more effective in promoting the increase in blood volume.(AU)

O presente estudo avaliou e comparou os efeitos de soluções eletrolíticas enterais hipotônicas, administradas por sonda nasoesofágica em fluxo contínuo em cães submetidos a restrição hídrica, sobre o hematócrito, proteínas totais séricas, osmolaridade sérica, volemia, glicose e lactato plasmáticos, hemogasometria, ânion gap e DIF. Foram utilizados seis cães adultos (quatro machos e duas fêmeas). Todos os animais foram submetidos aos dois tratamentos propostos, em um delineamento crossover 6×2. Os tratamentos foram os seguintes: SEmalt - 5g de cloreto de sódio, 1g de cloreto de potássio, 1g de acetato de cálcio, 0,2g de pidolato de magnésio e 9,6g de maltodextrina, diluídos em 1.000mL de água (osmolaridade mensurada: 215mOsm L -1 ); SEdext - 5g de cloreto de sódio, 1g de cloreto de potássio, 1g de acetato de cálcio, 0,2g de pidolato de magnésio e 9,6g de dextrose, diluídos em 1.000mL de água (osmolaridade mensurada: 243mOsm L -1 ). Todas as soluções foram administradas no volume de 15mL kg -1 hora -1 , durante quatro horas, em fluxo contínuo. Ambas as soluções aumentaram o volume plasmático em cães desidratados, sem gerar o aparecimento de efeitos adversos. Porém, a SEmalt foi mais eficaz em promover a expansão da volemia.

Animals , Dogs , Dehydration/therapy , Dehydration/veterinary , Fluid Therapy/methods , Fluid Therapy/veterinary , Hypotonic Solutions/therapeutic use , Hypovolemia/veterinary , Intubation, Gastrointestinal/veterinary
Braz. j. med. biol. res ; 43(7): 657-662, July 2010. ilus, tab, graf
Article in English | LILACS | ID: lil-550729


The objective of the present study was to describe motor behavioral changes in association with histopathological and hematological findings in Wistar rats inoculated intravenously with human T-cell lymphotropic virus type 1 (HTLV-1)-infected MT2 cells. Twenty-five 4-month-old male rats were inoculated with HTLV-1-infected MT2 cells and 13 control rats were inoculated with normal human lymphocytes. The behavior of the rats was observed before and 5, 10, 15, and 20 months after inoculation during a 30-min/rat testing time for 5 consecutive days. During each of 4 periods, a subset of rats was randomly chosen to be sacrificed in order to harvest the spinal cord for histopathological analysis and to obtain blood for serological and molecular studies. Behavioral analyses of the HTLV-1-inoculated rats showed a significant decrease of climbing, walking and freezing, and an increase of scratching, sniffing, biting, licking, and resting/sleeping. Two of the 25 HTLV-1-inoculated rats (8 percent) developed spastic paraparesis as a major behavioral change. The histopathological changes were few and mild, but in some cases there was diffuse lymphocyte infiltration. The minor and major behavioral changes occurred after 10-20 months of evolution. The long-term observation of Wistar rats inoculated with HTLV-1-infected MT2 cells showed major (spastic paraparesis) and minor motor abnormalities in association with the degree of HTLV-1-induced myelopathy.

Animals , Humans , Male , Rats , Human T-lymphotropic virus 1/physiology , Paraparesis, Tropical Spastic/virology , Disease Models, Animal , Enzyme-Linked Immunosorbent Assay , Human T-lymphotropic virus 1/genetics , Polymerase Chain Reaction , Paraparesis, Tropical Spastic/blood , Paraparesis, Tropical Spastic/pathology , Time Factors , Viral Load
Arq. ciênc. vet. zool. UNIPAR ; 7(2): 141-144, jul.-dez. 2004. ilus
Article in Portuguese | LILACS | ID: lil-418089


Os cistos de retenção de penas surgem como nódulos envolvendo um ou vários folículos das penas e sua ocorrência é devida a má formação da pena em crescimento sob a pele. São comuns em canários, principalmente os das raças Norwich e Gloucester. As formas de tratamento preconizadas são relativamente cruentas e susceptíveis a hemorragias. Este artigo descreve a utilizaçào do anti-inflamatório não esteróide, cloridrato de benzidamina, como método adjuvante para o tratamento desta anomalia. Nos últimos três anos, foram tratados 14 canários na Policlínica da Faculdade de Veterinária da Universidade Federal Fluminense (UFF) com a citada medicação, sendo esta administrada por via oral, diretamente no bico ou diluída na água de beber. As aves tratadas apresentaram maturação dos cistos, facilitando assim a remoção de seu conteúdo, sem os indesejáveis riscos de hemorragia.

Feather cysts appear as swellings involving a single or several feather follicles and are due to malformation of a developing feather under the skin. These cysts are particulary common in Norwich and Gloucester canaries. The recommended forms of treatment are relatively traumatic and may cause hemorrhages. This article describes the use of a non steroidal antiinfl amatory (benzidamina HCL) as an alternative method for the treatment of this anomaly. In the last three years, 14 canaries had been treated at the Veterinary Policlinic of the Universidade Federal Fluminense (UFF) with that drug, administered orally, directly in the beak or in the drinking water. Treated birds presented maturation of the cysts, facilitating the removal of their contents, without risks of hemorrhages.

Los quistes de las plumas aparecen como nódulosinvolucrando uno o varios folículos plumíferos, y esto se debe a una malformación en el desarrollo de la pluma debajo de la piel. Estos quistes son frecuentes en canarios, principalmente en las razas Norwich y Gloucester. Los tratamientos recomendados son relativamente cruentos y susceptibles a hemorragias. Este artículo describe la utilización de un anti-infl amatorio no esteroide (hidrocloruro de benzidamina) como método alternativo para el tratamiento de esta anomalía. En los últimos tres años, fueron tratados 14 canarios en la Policlínica de la Facultad de Veterinaria de la Universidade Federal Fluminense (UFF) con la citada medicación, la cual fue administrada oralmente, directamente en el pico o diluida en el agua de bebida. Las aves tratadas presentaron maduración de los quistes, facilitando laremoción de su contenido sin los indeseables riesgos de hemorragia.

Animals , Male , Female , Benzydamine/therapeutic use , Canaries , Cysts/veterinary
Arq. neuropsiquiatr ; 52(4): 585-91, dez. 1994. tab
Article in English | LILACS | ID: lil-150532


As paraparesia espástica tropical (PET) é uma mielopatia crônica progressiva e em muitos casos tem etiologia retroviral (HTLV-1) (MAH/PET). Cerca de 433 casos de PET têm sido descritos no Nordeste e Sudeste do Brasil, dos quais 157 (36,2 por cento) säo HTLV-1 positivos e 276 (63,7 por cento) Säo negativos. A média de idade dos pacientes é de 43,8 anos. Ocorre discreto predomínio de mulheres e mulatos, embora haja numerosos pacientes brancos. Clinicamente todos os pacientes exibem uma paraparesia espástica com variável distúrbio sensitivo e esfincteriano. Dor e sintomas autonômicos parecem expressivos nos pacientes brasileiros com MAH/PET HTLV-1 positivos

Humans , Male , Female , Adult , Paraparesis, Tropical Spastic/etiology , Brazil , Paraparesis, Tropical Spastic/diagnosis , Paraparesis, Tropical Spastic/cerebrospinal fluid , Sex Factors
Arq. neuropsiquiatr ; 52(1): 64-8, mar. 1994. tab, ilus
Article in English | LILACS | ID: lil-129367


Os autores descrevem um raro caso de hipertensäo intracraniana conseqüente a glioblastoma multiforme situado na medula cervical de uma paciente jovem. Analisam a fisiopatologia de hipertensäo intracraniana em tumores medulares e a raridade desse tipo de tumor nessa localizaçäo, assim como seus aspectos clínico-patológicos

Humans , Female , Adult , Glioblastoma/physiopathology , Intracranial Pressure/physiology , Spinal Cord Neoplasms/physiopathology , Glioblastoma/cerebrospinal fluid , Glioblastoma/diagnosis , Spinal Cord Neoplasms/cerebrospinal fluid , Spinal Cord Neoplasms/diagnosis , Tomography, X-Ray Computed
Arq. neuropsiquiatr ; 50(1): 120-2, mar. 1992.
Article in English | LILACS | ID: lil-121679


A mäo talâmica é um dos sinais clínicos na síndrome talâmica. Neste estudo é relatado o caso de uma paciente com síndrome de dor central (supratalamica) pos-ictal que apresenta também mäo talâmica. Os autores enfatizam a noçäo de que na síndrome de dor central pos-ictal, uma lesäo talâmica direta ou indireta (infra ou supratalâmica) é elemento fundamental para a gênese da dor central

Humans , Female , Middle Aged , Cerebrovascular Disorders/complications , Pain/etiology , Thalamus/injuries , Dystonia/complications , Monoamine Oxidase/physiopathology
Braz. j. med. biol. res ; 24(1): 43-7, jan.-mar. 1991. tab
Article in English | LILACS | ID: lil-99579


The present paper describes the determination of muscarinic receptor number ([3H]-N-methylscopolamine binding) and acetylcholinesterase activity in six brain areas (pre-central gyrus, post-central gyrus, hippocampus, caudate nucleus,lentiform nucleus and substantia inominata) of demented patients (diagnosed by screening tests and neurological evaluation) and age-matched controls.These was a significant increase in muscarinic receptors in the hippocampus and substanctia inominata (171.2 and 359.4fmol/mg protein, respectively) of the demented group as compared with controls (123.9 and 219.0 fmol/mg protein, respectively). No changes were observed in pre-and post-central gyrus, while a tendency towards decreased binding was detected in the caudate nucleus and lentiform nucleus of the demented group. Lower acetylcholinesterase activity was also detected in the demented group in all areas studied although the differences were significant only in the post-central gyrus, caudate nucleus and substantia inominata which showed a 49.21 and 25% decrease in enzyme activity respectively. The results are discussed in terms of a compensatory mechanism of presynaptic deficiency such as that occurring in Parkinson's disease

Aged , Humans , Male , Female , Acetylcholinesterase/metabolism , Brain/metabolism , Dementia/physiopathology , Receptors, Muscarinic/analysis , Aged, 80 and over , Binding Sites , Cerebral Cortex/pathology
Arq. neuropsiquiatr ; 42(3): 302-4, 1984.
Article in Portuguese | LILACS | ID: lil-20540


Os autores apresentam um caso de pupila tonica e discutem aspectos clinicos e fisiopatologicos dessa sindrome. Eles fazem consideracoes sobre lacunas na compreensao da etiopatogenia da sindrome

Humans , Female , Adie Syndrome
Rev. Med. Univ. Fed. Ceará ; 23(1/2): 73-7, 1983.
Article in Portuguese | LILACS | ID: lil-17751


O edema cerebral constitui uma entidade bastante frequente na clinica neurologica e neurocirurgica. Os autores discutem os diferentes aspectos fisiopatologicos, clinicos e terapeutico do edema cerebral.Eles salientam as perspectivas e lacunas existentes na compreensao fisiopatologica do mesmo, e mostram as atuais e futuras tendencias de progresso terapeutico

Brain Edema