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Article in English | WPRIM | ID: wpr-880991


OBJECTIVE@#Hemorrhoidal disease (HD) is the most common proctological disease, with an estimated prevalence rate of 4.4%, and a peak in individuals between 45 and 65 years of age. This study was done to evaluate whether Lian-Zhi-San (LZS), a clinically used anti-hemorrhoidal ointment could alleviate the inflammatory injury, with its associated changes of inflammatory cytokines and morphology of anorectal tissues, in an experimental model of HD in rats.@*METHODS@#HD was induced by croton oil preparation (COP) applied to the anorectal region. Rats were then treated with cotton swabs soaked in LZS ointment, water or white vaseline, twice a day for 7 d. At the end of the experiment, HD was evaluated by measuring hemorrhoidal and biochemical parameters along with histopathological observations.@*RESULTS@#In this study, COP induced a significant increase in the macroscopic severity score, anorectal coefficient and Evans blue extravasation, compared to normal rats. Additionally, it greatly enhanced the expression and secretion levels of some important inflammation-related cytokines along with marked histological damage, compared to normal rats. Rats treated with LZS ointment experienced significantly ameliorated Evans blue extravasation (P < 0.05), decreased macroscopic severity score (0.86 ± 0.14 vs. 1.65 ± 0.16) and the anorectal coefficient (P < 0.01); its use also attenuated tissue damage and inhibited the expression and secretion levels of inflammation-related cytokines (interleukin-1β, interleukin-6 and tumor necrosis factor-α).@*CONCLUSION@#This study validates a preliminary understanding of the use of LZS ointment to treat inflammatory factors and tissue damage in an experimental model of HD in rats.

Article in Chinese | WPRIM | ID: wpr-838759


Underwater weapons have been widely used and their applications have become a main characteristic of modern naval battles. It imposes a severe threat to the combatants above or below water surface. The injury mechanism and characteristics of underwater explosion are quite different from those of the land explosion, which has become a research focus of military medicine around the world. In this paper we systematically reviewed the literatures and the current status of biological effect of underwater explosion injury and discussed its future development, hoping to improve our understanding and promote further in-depth studies.

Article in Chinese | WPRIM | ID: wpr-838906


Coagulopathy is common in patients with traumatic brain injury (TBI). It is associated with the dysfunction of the normal clotting-anticoagulant-fibrinolytic system, with unknown pathogenesis. Recently a large number of studies have confirmed that the prognosis of TBI patients is closely related to coagulopathy of these patients at admission. Most prospective studies have also found that several coagulation abnormalities indicate poor prognosis. However, whether there is a cause and effect relationship between coagulopathy and prognosis of TBI patients, whether correcting abnormal coagulation parameters can improve the prognosis, all remain to be illuminated. Here we reviewed the related issue and hope to lay a foundation for future researches.