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Objective:To investigate the effect of early postoperative enteral nutrition(EN)on postoperative rehabilitation and inflammation after laparoscopic radical gastrectomy for gastric cancer,in order to provide reference for postoperative rehabilitation of such patients.Methods:Patients who received laparoscopic assisted radical gastrectomy in Department of Gastrointestinal Surgery of The First Affiliated Hospital of Bengbu Medical College from January 2020 to December 2022 were included in the analysis.According to the different ways of postoperative nutritional treatment,patients were divided into the observation group(early postoperative EN group)and the control group(parenteral nutrition group),and indexes such as postoperative rehabilitation,abdominal drainage flow and the level of inflammatory mediators in drainage fluid were compared between the two groups.Results:A total of 81 patients were included,including 41 in the observation group and 40 in the control group.Interval of the first postoperative exhaust(t=3.806;P<0.001)and resuming diet day(t=5.510;P<0.001),and length of postoperative hospital stay(t=2.401;P=0.019)in the observation group were shorter than those in the control group.Levels of peripheral blood albumin(t=14.040;P<0.001)and prealbumin(t=9.832;P<0.001)of the observation group at postoperative day(POD)5 were significantly higher than those of the control group,but there was no significant difference in hemoglobin level(t=1.477;P=0.144).The level of CRP in peripheral blood of the observation group at POD 5(t=7.758;P<0.001)and the incidence of postoperative SIRS[(12.2%,5/41)vs(32.5%,13/40),x2=4.830;P=0.028)]were significantly lower than those in the control group.The average drainage volume(t=6.858;P<0.001),drainage removal time(t=5.016;P<0.001),and TNF-α level(t=4.993;P<0.001)and IL-6 level(t=20.640;P<0.001)in postoperative drainage at POD 5 were significantly lower in the observation group than those in the control group.Conclusion:Early postoperative EN could accelerate the rehabilitation process after laparoscopic radical gastrectomy,improve postoperative nutritional status,and reduce abdominal inflammation.
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This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.
Subject(s)
Rats , Animals , Qi , Sesquiterpenes/pharmacology , Molecular StructureABSTRACT
Objective To study the chemical constituents from the ethnic medicines of Eleutherine americana. Methods Compounds were separated by silica gel and semi-preparative HPLC, detected by TLC, and identified by their NMR and MS data. Results Five compounds were isolated from E. americana. They were ameriquinone A (1), elecanacin (2), 3-[2-(acetyloxy) propyl]-2-hydroxy- 8-methoxy-1,4-naphthoquinone (3), 2-acetyl-1,8-di-methoxy-3-methylnaphthalene (4), and dihydroeleutherinol (5). Conclusion Compound 1 is a new compound. Compounds 1-5 have different degrees of inhibitory effect on the growth of Staphylococcus aureus and Escherichia coli. The MIC values of compound 5 against two strains were 0.30 μg/mL and 0.06 μg/mL, respectively.
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The present study is to investigate the chemical constituents and anti-inflammation of agarwood produced via whole-tree agarwood-inducing technique( Agar-Wit) from Aquilaria sinensis by column chromatographic technique and semi-preparation HPLC.Eleven sesquiterpenes were isolated from the agarwood produced by Agar-Wit,and their structures were identified on the basis of physiochemical characteristics and spectroscopic data analysis as baimuxinol( 1),5α,7α( H)-eudesm-11( 13)-en-4α-ol( 2),( 7 S,9 S,10 S)-( +)-9-hydroxy-selina-4,11-dien-14-al( 3),petafolia A( 4),7( 11)-eremophilen-8-one( 5),neopetasane( 6),petafolia B( 7),11-hydroxy-valenc-1( 10)-en-2-one( 8),( 4αβ,7β,8αβ)-3,4,4α,5,6,7,8,8α-octahydro-7-[1-( hydroxymethyl) ethenyl]-4α-methylnaphthalene-1-carboxaldehyde( 9),12-hydroxy-4( 5),11( 13)-eudesmadien-15-al( 10),and( 4 R,5 R,7 S,9 S,10 S)-(-)-eudesma-11( 13)-en-4,9-diol( 11). Among them,compound 1 was a new natural product,and this is the first time to report its13 CNMR spectroscopic data. Compounds 4,9 and 10 were reported from Aquilaria for the first time,and all the compounds are firstly isolated by Agar-Wit from A. sinensis. The anti-inflammatory activity of RAW264. 7 cells with lipopolysaccharide-induced was evaluated.As a result,1,4 and 9 showed potential anti-inflammatory activities with IC50 values( 2. 5±0. 35),( 3. 2±0. 2),( 4. 3±0. 56) μmol·L-1,respectively. This work provided scientific foundation for quality evaluation of the agarwood produced by Agar-Wit.
Subject(s)
Anti-Inflammatory Agents , Lipopolysaccharides , Sesquiterpenes , Thymelaeaceae , TreesABSTRACT
A new naphthalene derivative and three known compounds were isolated from the petroleum ether extract of the bulbs of Eleutherine americana by using various chromatographic techniques, such as column chromatography over silica gel and semi-preparative HPLC. Their structures were elucidated by spectroscopic date (MS, UV, IR, NMR), which were identified as eleutherol B (1), 4,8-dihydroxy-3-methoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (2), 8-hydroxy-3,4-dimethoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (3), and isoeleutherine (4). Compound 1 is a new compound. The diastolic blood vessels activity of compound 1 and 2 were potent, reaching 82.5% and 85.3% at the concentration of 10 μmol·L⁻¹, which were basically the same as that of the positive drug tanshinone ⅡA.
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Objective To study the chemical constituents of Mallotus furetianus. Methods The constituents were isolated and purified by silica gel chromatography and HPLC repeatedly, and the structures were identified by spectra analysis and chemical methods. Results Sixteen compounds were isolated from the leaves of M. furetianus, the structures were identified as 3-hydroxy-4,5 (R)-dimethy1-2 (5H)-furanone (1), gallic acid (2), 3,4,8,9,10-pentahydroxydibenzo [b, d] pyran-6-one (3), epicatechin (4), catechin (5), kaempferol-3-O-robinobioside (6), apigenin (7), 2-hydroxysuccinic acid (8), 5-hydroxymethylfuroic acid (9), gallic acid methyl ester (10), caffeic acid (11), tanshinol (12), diolmycin B2 (13), oresbiusin A (14), 3,4-dihydroxyphenyl-β- D-glucopyranoside (15), and (2S)-pyroglutamic acid (16). Conclusion Compounds 7-16 are obtained from the genus of Mallotus for the first time, and compounds 4-16 are obtained from M. furetianus for the first time.
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The genus Mallotus Lour. (Euphorbiaceae) consists of 140 species distributed in tropical and subtropical regines of Asia, 25 species and 11 varieties of which can be found in southern of China. Some species of the genus have been used in traditional medicine. Phytochemical studies on the plants in the genus have demonstrated the presence of large number of diterpenoids, triterpenoids, polyphenols, and tannins, along with some monoterpene, benzopyran, coumarin-lignin, diaryl heptane, flavonoids, alkaloids, coumarin, etc. Furthermore, many pharmacological activities of the plants in the genus, such as anti-atherosclerosis, choleretic, hepatoprotective, antioxidant, analgesic, immunity improvement, and memory enhancing activities have been reported. In this article, new development of constituents and biological activities of plants in Mallotus Lour. since 1988 were reviewed and summarized for providing a reference for the further study, exploitation, and utilization of this resource.