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Article in Chinese | WPRIM | ID: wpr-320665


<p><b>OBJECTIVE</b>To study the effects of ulinastatin on coagulation in children who underwent open-heart surgery with cardiopulmonary bypass (CPB).</p><p><b>METHODS</b>Fifty children who underwent open-heart surgery for ventricular septal defect were randomly divided into two groups: ulinastatin treatment and control. Before CPB, ulinastatin (1.0×10(4) U/kg) was added to CPB priming fluid only in the ulinastatin treatment group. Activated partial thromboplasin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen and international normalized ratio (INR) were measured both before and at 1 hr, 6 hrs and 24 hrs after CPB.</p><p><b>RESULTS</b>The PT in the ulinastatin group was more prolonged than in the control group at 1 hr after CPB (18.7 ± 0.7 s vs 15.5 ± 0.5 s) and 6 hrs after CPB (17.5 ± 0.6 s vs 15.0 ± 0.6 s). The APTT in the ulinatatin group was also significantly more prolonged than in the control group at 6 hrs after CPB (38.7 ± 3.1 s vs 35.3 ± 3.1 s) and 24 hrs after CPB (34.2 ± 3.0 s vs 31.1 ± 2.6 s).</p><p><b>CONCLUSIONS</b>Ulinastatin may prolong PT and APTT after CPB, and thus affects coagulation in children.</p>

Blood Coagulation , Cardiac Surgical Procedures , Cardiopulmonary Bypass , Female , Glycoproteins , Pharmacology , Humans , Infant , Male , Partial Thromboplastin Time , Prothrombin Time , Trypsin Inhibitors , Pharmacology
Chinese Journal of Surgery ; (12): 410-412, 2004.
Article in Chinese | WPRIM | ID: wpr-299934


<p><b>OBJECTIVE</b>To present the clinical application of composite graft of acellular allo-dermis matrix (ADM) with thin auto-microskin on burn wound.</p><p><b>METHODS</b>8 inpatients with 18 full thickness skin burn wounds were transplanted with allo-ADM after eschar was excised, then the auto-microskin and allo-human skin were covered on the area of the matrix, the wound where no allo-ADM grafting were covered as control groups only with auto-microskin and allo-human skin. The area of donor to wound is 1:5 - 1:8.</p><p><b>RESULTS</b>Survived rate of 18 pieces composite skin that allo-ADM with auto-microskin were grafted were 94%. After following up for 3 to 13 months, the skins of complex grifting had well elastic and smooth texture compared to auto-microskin grafted, they appeared less cicatrisation and ulceration. 3 months after operation, it was indicated by histological examination that tightknit the epithelial-dermal conjunction and epidermal papilla structure could be identified in the allo-ADM skin and there were orderly collagenous fibres, but scar skin structure was observed in that auto-microskin grifted area.</p><p><b>CONCLUSION</b>The graft effectiveness of allo-ADM and auto-microskin was better than that of auto-microskin, and this method could be used on major deep burn wound healing.</p>

Adult , Burns , General Surgery , Female , Humans , Male , Middle Aged , Skin Transplantation , Methods , Tissue Donors , Transplantation, Autologous , Transplantation, Homologous , Treatment Outcome