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1.
Arq. neuropsiquiatr ; 67(2b): 391-395, June 2009. ilus, tab
Article in English | LILACS | ID: lil-519263

ABSTRACT

OBJECTIVE: To evaluate the fractional anisotropy (FA) values of the multiple sclerosis (MS) plaques and normal-appearing cervical spinal cord (NASC) by diffusion tensor MRI imaging (DTI). METHOD: Forty-one patients with relapsing-remising MS and 37 controls were evaluated. All MRI exams were performed using a conventional protocol, as well as diffusion tensor MR imaging. Regions of interest were placed within the spinal cord lesions and in the normal appearing spinal cord adjacent to the plaque. RESULTS: The FA values were statistically reduced in the plaques compared to the surrounding NASC and to equivalent location in controls. A reduction in FA values was also observed in the spinal cord of MS patients without visible lesions on T2WI. CONCLUSION: We observed reduced fractional anisotropy in the demyelinating plaques and in the NASC of MS patients, corroborating the hypothesis that the histological extension of the MS lesions is more severe than the abnormalities seen in the conventional MRI sequences.


OBJETIVO: Avaliar os valores da anisotropia fracionada (FA) em pacientes com esclerose múltipla (EM) nas placas e na medula espinhal aparentemente normal (MEAN). MÉTODO: Quarenta e um pacientes com EM remitente-recorrente e 37 controles foram examinados. Todos os exames foram realizados com protocolo convencional, assim como imagens por tensor de difusão. Regiões de interesse foram definidas nas placas da medula espinhal e na MEAN ao redor das placas. RESULTADOS: Os valores de FA estavam significativamente reduzidos nas placas, comparados à MEAN ao redor e às regiões equivalentes dos controles. Redução dos valores de FA também foi demonstrada na medula espinhal de pacientes com EM sem lesões visíveis nas imagens de RM pesadas em T2. CONCLUSÃO: Observamos redução dos valores de anisotropia fracionada nas placas de desmielinização e na MEAN, corroborando a hipótese de que a extensão histológica das lesões na EM é maior que as alterações de sinal vistas nas seqüências convencionais de ressonância magnética.


Subject(s)
Adult , Female , Humans , Male , Diffusion Magnetic Resonance Imaging , Multiple Sclerosis, Relapsing-Remitting/pathology , Spinal Cord/pathology , Anisotropy , Case-Control Studies , Retrospective Studies
3.
Arq. neuropsiquiatr ; 66(1): 64-68, mar. 2008. ilus
Article in English | LILACS | ID: lil-479652

ABSTRACT

Pineoblastomas are uncommon pineal tumors, which demonstrate rapid growing and poor prognosis. We report the case of a 43-year-old man with an enhancing pineal region mass, which showed restriction of the diffusion on diffusion-weighted (DW) MR images. The surgical biopsy defined the diagnosis of pineoblastoma and the therapy was initiated with radiation and chemotherapy. Three months later, the follow-up MR imaging showed areas suggestive of necrosis and the DW images demonstrate no significant areas of restricted diffusion. The differential diagnosis of pineal region masses that could show restriction of diffusion is discussed.


Pineoblastomas são tumores incomuns da glândula pineal, os quais têm crescimento rápido e prognóstico reservado. Os autores objetivam relatar o caso de um homem de 43 anos de idade com uma massa na região pineal com realce pelo contraste, a qual demonstrou restrição da difusão nas imagens de ressonância magnética (RM) pesadas em difusão. A biópsia cirúrgica definiu o diagnóstico de pineoblastoma e o tratamento foi iniciado com radio e quimioterapia. Três meses mais tarde, a RM de controle demonstrou áreas sugestivas de necrose e não mais eram observadas áreas de restrição da difusão da água. O diagnóstico diferencial das massas na região pineal que podem apresentar restrição da difusão é discutido.


Subject(s)
Adult , Humans , Male , Brain Neoplasms/diagnosis , Pineal Gland , Pinealoma/diagnosis , Brain Neoplasms/pathology , Brain Neoplasms/therapy , Diagnosis, Differential , Diffusion Magnetic Resonance Imaging , Follow-Up Studies , Pineal Gland/pathology , Pinealoma/pathology , Pinealoma/therapy
4.
Arq. neuropsiquiatr ; 57(3A): 672-7, set. 1999. ilus
Article in English | LILACS | ID: lil-242275

ABSTRACT

The purpose of this study is to describe two infants that were diagnosed with Walker-Warburg syndrome (WWS), a rare form of congenital muscular dystrophy (CMD). They were studied in their clinical, laboratory, and neuroradiologic features. The index case had a brain magnetic resonance imaging (MRI) and the second patient had a head computerized tomography (CT). In addition, a literature review was performed to describe the main forms of CMD. The index case fulfilled all criteria for WWS. A brain MRI performed at age 4 months served to corroborate the clinical diagnosis, showing severe hydrocephalus, type II lissencephaly, cerebellar vermian aplasia, and a hypoplastic brain stem. The authors were able to establish a retrospective diagnosis of WWS in the index cases's older sister, based upon her clinical picture and head CT report.


Subject(s)
Humans , Female , Infant , Hydrocephalus/diagnosis , Muscular Dystrophies/congenital , Muscular Dystrophies/diagnosis , Abnormalities, Multiple/diagnosis , Abnormalities, Multiple/pathology , Brain/abnormalities , Brain/pathology , Hydrocephalus/pathology , Magnetic Resonance Imaging , Muscular Dystrophies/classification , Muscular Dystrophies/pathology , Prenatal Diagnosis , Syndrome , Tomography, X-Ray Computed
5.
Arq. neuropsiquiatr ; 56(4): 838-40, dez. 1998. ilus
Article in Portuguese | LILACS | ID: lil-226029

ABSTRACT

Descrevemos o caso de um paciente de 45 anos de idade com cefaléia postural secundária a hipotensao liquórica espontânea, no qual a ressonância nuclear magnética do crânio revelou impregnaçao de contraste e espessamento meníngeo.


Subject(s)
Humans , Male , Middle Aged , Intracranial Hypotension/diagnosis , Magnetic Resonance Spectroscopy
6.
Rev. bras. ortop ; 32(7): 581-2, jul. 1997. ilus
Article in Portuguese | LILACS | ID: lil-208679

ABSTRACT

Os autores apresentam quatro casos de pacientes com quadro clínico de neuroma interdigital plantar (neuroma de Morton), cujos diagnósticos foram confirmados pela ressonância magnética.


Subject(s)
Humans , Foot Diseases/diagnosis , Metatarsal Bones , Neuroma/diagnosis , Magnetic Resonance Imaging
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