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China Pharmacy ; (12): 1453-1459, 2021.
Article in Chinese | WPRIM | ID: wpr-881281


OBJECTIVE:To establ ish characteristic pattern of vinegar-processed product of Schisandra chinensis formula granules from different habitats ,and to determine the contents of 5 components. METHODS :HPLC method was adopted. The determination was performed on Agilent ZORBAX SB-C 18 column with mobile phase consisted of acetonitrile-water (gradient elution)at the flow rate of 1.0 mL/min. The column temperature was set at 30 ℃,and detection wavelength was set at 220 nm. The sample size was 10 µL. Using schisandrin as reference ,HPLC characteristic pattern of 19 batches of vinegar-processed S. chinensis formula granules was drawn. The similarity evaluation was performed with Similarity Evaluation System of TCM Chromatographic Fingerprints (2012 edition),and common peaks were confirmed. The contents of schisandrin ,schisandrol, angeloylgomisin H ,schizandrin and deoxyschizandrin were determined by same method. RESULTS :There were 8 common peaks in 19 batches of vinegar-processed S. chinensis formula granules ,and the similarities were all above 0.996;five of them were identified as schisandrin ,schisandrol,angeloylgomisin H ,schizandrin and deoxyschizandrin ,respectively. The linear range of schisandrin,schisandrol,angeloylgomisin H ,schizandrin and deoxyschizandrin were 0.030-0.380,0.016-0.195,0.009-0.115, 0.006-0.078 and 0.011-0.138 μg(r>0.999),respectively. RSDs of precision ,stability(24 h)and reproducibility tests were all lower than 2%. Average recoveries were 99.84%,99.54%,99.28%,100.03%,100.27%(RSD<1.4%,n=9). Average contents of five components in 19 batches of samples were in the range of 0.15%-0.36%,0.02%-0.16%,0.02%-0.06%,0.02%-0.08% and 0.08%-0.17%,respectively;among them ,total contents of five components in sample S 18 and S 19 from Hebei province were relatively high ,while those were relatively low in sample S 16 and S 17(RSD=42%);RSD of total content in other samples (S1-S15)was 12%,and was lower than that of Hebei province ;total content of five components were higher in sample from Jilin province. CONCLUSIONS : Established characteristic pattern and method for the content determination are specific and reproducible,and can be used for the quality evaluation of vinegar-processed S. chinensis formula granules. The total content fluctuation of vinegar-processed product of S. chinensis formula granules from Liaoning ,Jilin and Heilongjiang provinces is lower than that in Hebei province ,and the quality of vinegar-processed Δ 基金项目:国家中药标准化项目(No.ZYB2H-Y-GD-13) *主管中药师 ,硕士 。研究方向 :中药质量标准 。E-mail: S. chinensis formula granules from Jilin province is the best.

Article in Chinese | WPRIM | ID: wpr-452292


Objective To evaluate the feasibility, safety and effectiveness of interventional occlusion with thin waist occluder for perimembranous ventricular septal defect with pseudoaneurysm. Methods During the period from March 2008 to March 2013 at Shanghai Yodak Cardiothoracic Hospital , interventional occlusion with thin waist occluder was carried out in a total of 96 patients with perimembranous ventricular septal defect (VSD) complicated by pseudoaneurysm. The patient’s age varied from 2 years to 36 years. Before the procedure, routine left ventricular angiography and ascending aortic angiography were carried out. Left ventricular angiography and ascending aortic angiography as well as the transthoracic ultrasonography were performed immediately after the procedure to observe the therapeutic results. Follow-up checkups with transthoracic ultrasonography, EKG and chest X-ray film were conducted at one week as well as at one, 3, 6 and 9 months after the surgery were conducted. Results Successful occlusion of VSD was obtained in 93 patients, with a success rate of 96.8% (93/96). After the surgery, small amount of shunt flow was detected in 8 patients, which disappeared within 48 hours in 7 patients, and in the other one the shunt flow disappeared one month later which was confirmed by follow-up examination. After the treatment, complete right bundle branch block occurred in 4 patients, complete left bundle branch block in 5 patients, and transientⅢdegree atrioventricular block in one patient. The conduction block disappeared at the time of discharge in all patients. The left ventricular end-diastolic diameter (LVEDD) decreased from preoperative (47.5 ± 5.2) mm to postoperative (45.2 ± 5.1) mm, the difference was statistically significant (t = 18.33, P < 0.01). During the follow-up period lasting for 9 months, no delayed cardiac arrhythmia, valve damage or sudden death occurred. Conclusion For the treatment of perimembranous ventricular septal defect with pseudoaneurysm, interventional occlusion with thin waist occluder is safe and effective with excellent mid-term effect. Based on the imaging findings, including the location, shape, ruptured orifice, number of the perimembranous pseudoaneurysm as well as the distance between the pseudoaneurysm and the aortic valve, to select suitable occluder and proper occlusion site is the key to ensure a successful surgery.

Article in Chinese | WPRIM | ID: wpr-442527


Objective To analyze the clinical significance of four kinds of microalbuminuria detection in early diagnosis of iodinated contrast agent damage to kidney by studying four elements in the patients' urine:microalbumin (mAlb),immunoglobulin G (IgG),α1-microglobulin (α1-MG) and β2-microglobulin (β2-MG).Methods 106 patients who have received percutaneous coronary interventional therapy were chosen and divided into group A(angiography dose < 100ml,n =51) and group B (angiography dose ≥ 100ml,n =55) according to the amount of contrast agent used.Changes in the amount of mAlb,IgG,α1-MG and β2-MG levels,serum creatinine(Scr),endogenous creatinine clearance rate(eGFR) in the urine of the patients before and after the surgery were observed.Results Postoperative α1-MG and β2-MG levels in the urine of group A higher than before surgery (t =-6.748,-11.173,all P <0.0 5).2 4 hours after the surgery,mA1b,IgG,α1-MG and β2-MG levels in group B were elevated than before surgery,and the differences were significant(t =-6.223,-3.518,-11.532,-10.773,all P < 0.05).Two groups had significant differences in terms of mAlb,IgG,α1-MG and β2-MG levels after the surgery (F =27.306,4.704,5.118,19.011,all P < 0.05).Conclusion Four kinds of microalbuminuria detecting are conducive to early diagnosis of iodinated contrast agent damage to kidney and assessing the damage degree.The contrast agent damage to kidney first occurs as the renal tubular damage.When the contrast agent was used at a dosage of more than 100ml,glomerular damage occurred.

Article in Chinese | WPRIM | ID: wpr-438325


This study was aimed to investigate the blood-enriching effect of processed Radix Polygoni Multiflori on blood deficiency rats. A total of 140 SD rats were randomly divided into 14 groups, which were the blank control group, blood deficiency model group, positive control group and 11 test groups. The blank control group and model control group were treated with distilled water and the positive control group was given X ue b ao Buxue soluble granules. The test groups were treated with 11 different kinds of processed Radix Polygoni Multiflori sam-ples at a dosage of 2 g?kg-1 respectively. All rats were given drugs once a day. After 10 days, blood samples were collected and the amount of red blood cell (RBC), hemoglobin (Hb), haematocrit (HCT), whole blood viscos-ity and plasma viscosity, prothrombin time were estimated. The results showed that 9 processed Radix Polygoni Multiflori groups can increase the number of RBC and Hb significantly ( P < 0 . 05 or P < 0 . 01 ) in blood deficien-cy rat models. They were the sample processed with decoction of black soybean (DBS) for 24 h, with wine and DBS combination for 24 h , steamed for 4 h and 8 h under high pressure , with DBS for 6 h and 8 h , with wine for 6 h, with wine and DBS combination under high pressure, respectively. The samples processed with DBS un-der high pressure for 8 h increased RBC and Hb were more obviously ( P < 0 . 01 ) . The 8 groups can improve the situation of functional disorder of blood rheology significantly ( P < 0 . 05 or P < 0 . 01 ) . They were the unprocessed samples, processed with DBS and wine for 24 h respectively, with DBS and wine combination for 24 h, steamed for 4 h and 8 h or steamed with DBS for 6 h and 8 h or with wine for 6 h under high pressure respectively. It was concluded that the blood-enriching effect was improved while the R adix Polygoni Multiflori was processed with DBS or wine and under high pressure for 6-8 h .

Article in Chinese | WPRIM | ID: wpr-263962


For the purpose of stabilizing and enhancing the clinical effect, the author suggested that it should develop the key technology of integrated innovation research such as origin producing area processing technology, medicinal parts and energy-saving rapid drying technology, process control technology, quality evaluation key technology, packaging and bar code identification technology to establish the quality assurance system of processed Chinese medicine, which is the key to ensure the clinical effect of traditional Chinese medicine.

Drugs, Chinese Herbal , Reference Standards , Humans , Medicine, Chinese Traditional , Reference Standards , Quality Control , Technology, Pharmaceutical
Article in Chinese | WPRIM | ID: wpr-587589


Objective:To study and compare coronary lesion by angiography between Chinese and Australian. Methods:3 021 Chinese patients from Nanjing and 3 230 Australian patients from Sydney,whom were suspected to have coronary heart disease(CHD),were included for coronary angiography.The coronary lesion was evaluated by the number and location of coronary lesion. Results:① 69.4% patients were diagnosed with CHD in Chinese,and 75.5% in Australian(P