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1.
Article in Chinese | WPRIM | ID: wpr-872032

ABSTRACT

Objective:To provide reference for domestic colleagues by introducing the contents of the discipline construction of the National Clinical Research Center for mental disorders.Methods:By reviewing the original intention of the construction of the National Clinical Research Centers initiated by many ministries and departments, taking into account of the actual construction practice at hospital level in the field of mental disorders, this paper discusses the discipline construction of the National Clinical Research Center.Results:From the aspects of construction goals, purposes, overall operation modes, construction of collaborative innovation research network, the paper clarifies the concrete measures of the construction of the center.Conclusions:Through the evaluation of the current situation, the National Clinical Research Center for mental disorders has defined the focus of the construction: to build a management platform and two professional platforms, in order to provide support for the development of high-quality and high-level clinical research, and provide support for the transformation of clinical medicine.

2.
Article in Chinese | WPRIM | ID: wpr-712286

ABSTRACT

Objective Through combing the existing problems in the management policy of scientific research funds,this paper puts forward some constructive suggestions in reality.Methods Summarize the characteristics of scientific research fund management policies in related documents published in recent years,and systematically analyze the problems encountered in practical work.Resuits This paper points out some problems that will be encountered when carrying out the management policies of scientific research funds,further putting forward the policy suggestions.Conclusions Regulations of management for scientific research projects at the national level keep pace with times and are of great significance.In the process of implementation,it will be more scientific,reasonable and effective if there were more specific policy guidance,fully consideration on the mental labor value of scientists and wide application of information technology.

3.
Chinese Mental Health Journal ; (12): 17-21, 2017.
Article in Chinese | WPRIM | ID: wpr-703966

ABSTRACT

This article reviews studies on the heredity of personality disorders and family environment factors from the population-based studies, and summarizes the interaction between genetic factors and environmental factors. Studies have shown that there is a genetic basis for personality disorders, including family studies, twin studies, and neurophysiological studies. In addition, environmental factors, including social psychological factors, also play an important role in the development of personality disorder. In sum, the occurrence of personality disorder is the result of interactions between genetic factors and environmental factors. This paper snmmarizes sresearch on personality disorders, and investigates the role of interaction between genetic and environmental factors in the development of personality disorders. Such evidence has implications for effective prevention and intervention of personality disorders.

4.
China Pharmacy ; (12): 1322-1325, 2016.
Article in Chinese | WPRIM | ID: wpr-504408

ABSTRACT

OBJECTIVE:To study the protective effect of Glycyrrhiza uralensis polysaccharide (GUP) on CCl4 induced acute liver injury in mice and its mechanism. METHODS:60 ICR mice were randomly divided into normal control group (normal sa-line),model group(normal saline),bifendate group(positive drug,100 mg/kg)and GUP high-dose,medium-dose and low-dose groups (400,200 and 100 mg/kg). They were given relevant medicine intragastrically once a day. 15 d later,acute liver injury model was induced by intraperitoneal injection of CCl4 in those groups except for normal control group,and liver index was deter-mined. The levels of AST and ALT in serum,the NOS,NO,SOD,GSH-Px and MDA levels in liver tissues were detected. RE-SULTS:Compared with normal control group,the liver index,the levels of AST and ALT in serum and NOS,NO and MDA in liver tissue increased in model group,while SOD and GSH-Px levels in liver tissue decreased(P<0.05);liver cells became swell-ing,degeneration and necrosis,showed obvious inflammatory injury. Compared with model group,the liver index of GUP groups decreased,there was statistical significance in GUP high-dose medium-dose groups (P<0.05);the levels of AST and ALT in se-rum and NOS,NO and MDA in liver tissue of mice decreased in GUP groups,while the level of SOD and GSH-Px in liver tissue increased(P<0.05);liver cellular swelling,degeneration and necrosis relieved,and pathological injury had been improved. CON-CLUSIONS:GUP has a certain protective effect on CCl4-induced acute liver injury in mice and its protective effect may be related to antioxidation,decrease of NOS and NO levels,and reduction of the production of free radicals.

5.
Article in Chinese | WPRIM | ID: wpr-475504

ABSTRACT

Bibliometrical method was used in this article to analyze the publications in a hospital from 2004 to 2013.Results show that the number of publications increased during 8 years,and the quality has been improved consistently.However,the rate of clinician participation in research and the present of core authors were still on the lower side.Besides,the age structure of core authors is steady and lack of growth.Based on this analysis,we summarized the past experience and explored the strategies of research management.

6.
Article in Chinese | WPRIM | ID: wpr-470806

ABSTRACT

With the country's increasing investment in scientific research,research funding corruption cases frequently occurred to researchers and research funding management have sounded the alarm.In these cases,not only a few scientific elites become prisoners,as well as part of the management people related to scientific research projects,such as finance,purchasing personnel,also get involved for varieties of reasons,for profit.This paper,according to the requirements for scientific research funding management,analyzes the current major problems and the reasons in management process of scientific research funding,to further explore appropriate countermeasures to strengthen and standardize the management of scientific research funding.

7.
Article in Chinese | WPRIM | ID: wpr-431420

ABSTRACT

Medical research contracts including the state-funded research contracts and enterprises-funded research contract,The application of law and dispute resolution approach depends on the legal nature of two contracts.Therefore,the legal nature of the medical research contracts and contract risk prevention is the focus of this study.

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