Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 1 de 1
Singapore medical journal ; : 153-156, 2016.
Article in English | WPRIM | ID: wpr-296459


<p><b>INTRODUCTION</b>This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus.</p><p><b>METHODS</b>A total of 64 male Sprague Dawley® rats, each weighing 250 g, were randomly distributed into four groups: (a) normal control; (b) diabetic control; (c) diabetic with vitamin A, C and E supplementation; and (d) diabetic with omega-3 fatty acid supplementation. The animals were anaesthetised after four weeks of intervention, and paraoxonase and arylesterase activity in blood plasma, and liver and heart homogenates were measured.</p><p><b>RESULTS</b>Arylesterase activity in the heart and liver homogenates was significantly lower in the diabetic control group than in the normal control group (p < 0.01). Vitamin A, C and E supplementation, and omega-3 fatty acid supplementation significantly increased liver arylesterase activity (p < 0.05). No significant change was observed in paraoxonase activity and other investigated factors.</p><p><b>CONCLUSION</b>Vitamin A, C and E, or omega-3 fatty acid supplementation were found to increase liver arylesterase activity in streptozotocin-induced diabetic rats. These supplements may be potential agents for the treatment of diabetes mellitus complications.</p>

Animals , Male , Rats , Aryldialkylphosphatase , Metabolism , Ascorbic Acid , Pharmacology , Carboxylic Ester Hydrolases , Metabolism , Diabetes Mellitus, Experimental , Diet Therapy , Metabolism , Dietary Supplements , Fatty Acids, Omega-3 , Pharmacology , Liver , Myocardium , Rats, Sprague-Dawley , Vitamin A , Pharmacology , Vitamins , Pharmacology