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1.
Chinese Journal of Nephrology ; (12): 465-473, 2021.
Article in Chinese | WPRIM | ID: wpr-911875

ABSTRACT

Objective:To investigate the effects of hyperuricemia on the prognosis of IgA nephropathy (IgAN) using propensity score matching (PSM) method.Methods:IgAN patients proven by biopsy were included. PSM was used to match patients. Kaplan-Meier method was used for survival analysis, and Cox regression analysis was used to analyze the effects of hyperuricemia on IgAN prognosis. Primary outcome events were defined as death, or end-stage renal disease (dialysis, transplantation), or a decrease in estimated glomerular filtration rate (eGFR) greater than 40%. Renal outcome was defined as end-stage renal disease (dialysis, transplantation), or a decrease in eGFR greater than 40%.Results:A total of 1 454 IgAN patients were included in this study, including 850 females and 604 males. Uric acid level was (368.26±92.87) μmol/L in the males, and (277.23±92.71) μmol/L in the females. The median follow-up time was 85.00(56.10, 106.33) months. During the follow-up period, a total of 134 patients reached the primary outcome events, including 5 deaths, 24 dialysis patients, 5 kidney transplant patients, and 100 patients with eGFR decreased by more than 40%. After 1∶1 matching, 131 males and 159 females in the hyperuricemia group were successfully matched with 131 males and 159 females in the normal uric acid group, and there was no significant statistical difference in each parameter in baseline between the hyperuricemia group and normal uric acid group after matching. Kaplan-Meier survival analysis showed that either before or after matching, the incidence of primary outcome events in male or female patients with hyperuricemia was higher than those with normal uric acid, but there was no statistically significant difference in incidence of primary outcome events between female hyperuricemia group and female normal uric acid group after matching (Log-rank test, χ2=3.586, P=0.058). Cox proportional hazard regression model showed that, in the pre-match fully adjusted model, the hazard ratio ( HR) of entering primary outcome events was 2.29-fold (95% CI 1.27-4.11, P=0.006) for men with hyperuricemia and 1.85-fold (95% CI 1.01-3.37, P=0.045) for women with hyperuricemia compared with those with normal uric acid. In the post-match fully adjusted model, the HR of entering primary outcome events was 2.41-fold (95% CI 1.18-4.93, P=0.016) for men with hyperuricemia and 1.83-fold (95% CI 0.91-3.67, P=0.091) for women with hyperuricemia compared with those with normal uric acid. In the pre-match fully adjusted model, the HR of entering renal outcome events was 2.68-fold (95% CI 1.47-4.88, P=0.001) for men with hyperuricemia and 1.81-fold (95% CI 0.99-3.33, P=0.056) for women with hyperuricemia compared with those with normal uric acid. In the post-match fully adjusted model, the HR of entering renal outcome events was 2.89-fold (95% CI 1.36-6.15, P=0.006) for men with hyperuricemia and 1.81-fold (95% CI 0.88-3.72, P=0.106) for women with hyperuricemia compared with those with normal uric acid. Conclusion:Hyperuricemia may be associated with IgAN progression, and it has a more significant effect on male IgAN patients.

2.
International Eye Science ; (12): 1816-1819, 2021.
Article in Chinese | WPRIM | ID: wpr-886731

ABSTRACT

@#AIM: To investigate the relationship between platelet parameters and macular edema(ME)in retinal vein occlusion(RVO)patients with different OCT types.<p>METHODS: Retrospective study. A total of 126 eyes in 126 patients with RVO were enrolled in the ophthalmology department of the Fifth Affiliated Hospital of Zhengzhou University from December 2016 to February 2021, among whom, 51 eyes with central retinal vein occlusion(CRVO)were included, branch retinal vein occlusion(BRVO)included 75 eyes, 31 eyes without ME(non-ME)and 95 eyes with ME. According to the morphology of OCT, ME was divided into 26 eyes of diffuse retinal thickening(DRT), 30 eyes of cystoid macular edema(CME)and 39 eyes of serous retinal detachment(SRD), the platelet parameters of patients with different groups including platelet count(PLT), mean platelet volume(MPV), plateletcrit(PCT)and platelet distribution width(PDW)were collected and statistical analysis were performed.<p>RESULTS:The MPV value and CMT value of ME group was higher than that of Non-ME group(all <i>P</i><0.001), the MPV value of SRD group was higher than that of DRT group and CME group(all <i>P</i><0.001), but there was no statistically significant difference in MPV between DRT group and CME group(<i>P</i>=0.526), CMT in SRD group was significantly higher than that in DRT group and CME group(<i>P</i><0.001), and there was no significant difference in CMT between DRT group and CME group(<i>P</i>=0.190).<p>CONCLUSION:MPV has differences in patients with RVO ME with different OCT classifications, activated platelets may be closely related to the occurrence and development of SRD.

3.
Article in Chinese | WPRIM | ID: wpr-885699

ABSTRACT

To study the clinical effect of non-ampullary duodenal mucosal lesions treated by endoscopic resection. A retrospective analysis was performed on the data of 58 cases of duodenal non-ampullary mucosal lesions treated by endoscopic resection from January 2016 to June 2019 from 3 hospitals. Among 58 cases, 27 lesions (46.6%) were located in the duodenal bulb and 31 (53.4%) in the duodenal descending part (including the ball-drop boundary). Forty-six patients (79.3%) received endoscopic mucosal resection, 7 (12.1%) received endoscopic submucosal dissection and 5 (8.6%) received pre-cut endoscopic mucosal resection. Few postoperative complications were found except for 1 case of intraoperative bleeding, 1 case of delayed bleeding 2 days after surgery, 1 case of lesion residual and 2 cases of postoperative abdominal pain. No perforation occurred. Endoscopic treatment of non-ampullary duodenal mucosal lesions is safe and effective.

4.
Journal of Experimental Hematology ; (6): 1391-1396, 2020.
Article in Chinese | WPRIM | ID: wpr-827106

ABSTRACT

OBJECTIVE@#To analyze the reentry situation of HBsAg single reagent reactive blood donors in Anhui province, and to verify the rationality and effectiveness of reentry strategy of blood donors in Anhui province.@*METHODS@#Shielded blood donors who were HBsAg single reagent reactive might voluntarily apply for returning to the team of blood donors after the shield of 6 months. Blood bankstaff that shielded those donors should draw blood and conduct screening tests. Samples from donors who were HBsAg negative should be delivered to Anhui Blood Center to conduct the reentry detections. Shielded blood donors were allowed to return to the team if the results of HBsAg test, neutralization test, HBcAb test and nucleic acid test were negative.@*RESULTS@#109 person-portions of samples for returning to team from September 2013 to December 2016 were delivered to Anhui Blood Center. After reentry tests, 60 of them were negative, 8 cases were positive, while 41 cases were undetermined, and the qualified rate was 55.05%.25 negative donors were from Hefei, 20 of them donated blood again and were negative.@*CONCLUSION@#The shielding and reentry strategy of blood donors with HBsAg single reagent reactive in Anhui province is rational and effective. However, there are still some deficiencies in trace of donors and information transmission, which needs to be further improved.


Subject(s)
Blood Donors , DNA, Viral , Hepatitis B , Hepatitis B Surface Antigens , Hepatitis B virus , Humans
5.
Chinese Medical Journal ; (24): 2338-2345, 2020.
Article in English | WPRIM | ID: wpr-826404

ABSTRACT

Increasing numbers of targeted drugs are used in hormone receptor (HR)-positive metastatic breast cancer (MBC) to overcome or delay resistance to endocrine therapy. This study will systemically review the progress made in endocrine therapy combined with targeted therapy in the treatment of HR-positive MBC. From the "AI (aromatase inhibitor) era" represented by aromatase inhibitors, we have gradually entered the "post-AI era" represented by fulvestrant. Under the guidance of research on the molecular mechanism of endocrine therapy resistance, the "combination of endocrine therapy and targeted therapy" era is approaching. The development of drugs that target endocrine therapy resistance has concentrated on cyclin-dependent kinase 4/6 inhibitors, histone deacetylase inhibitors, and inhibitors of drug targets in the phosphatidylinositol 3 kinase-protein kinase B-mammalian target of rapamycin (PI3K-AKT-mTOR) pathway, providing new strategies for HR-positive MBC. Exploring biomarkers to guide the more precise use of targeted drugs in endocrine therapy for MBC is the focus of current and future research.

6.
Article in English | WPRIM | ID: wpr-826393

ABSTRACT

Bone tissue engineering has emerged as a promising alternative therapy for patients who suffer bone fractures or defects caused by trauma, congenital diseases or tumours. However, the reconstruction of bone defects combined with osteoporosis remains a great challenge for clinicians and researchers. Based on our previous study, Ca-Si-based bioceramics (MSCs) showed enhanced bone formation capabilities under normal conditions, and strontium was demonstrated to be therapeutic in promoting bone quality in osteoporosis patients. Therefore, in the present study, we attempted to enlarge the application range of MSCs with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes. In vitro readout suggested that Sr-incorporated MSC scaffolds could enhance the expression level of osteogenic and angiogenic markers of osteoporotic bone mesenchymal stem cells (OVX BMSCs). Animal experiments showed a larger new bone area; in particular, there was a tendency for blood vessel formation to be enhanced in the Sr-MSC scaffold group, showing its positive osteogenic capacity in bone regeneration. This study systematically illustrated the effective delivery of a low-cost therapeutic Sr agent in an osteoporotic model and provided new insight into the treatment of bone defects in osteoporosis patients.

7.
International Eye Science ; (12): 970-973, 2020.
Article in Chinese | WPRIM | ID: wpr-821567

ABSTRACT

@#Retinitis pigmentosa is an inherited eye disease. The inheritance methods include autosomal dominant inheritance, autosomal recessive inheritance, and sex-linked recessive inheritance. Currently, there are more than 3,000 mutation sites, which makes clinical treatment of this disease difficult. Ophthalmologists are committed to exploring the treatment of retinitis pigmentosa, and have conducted a large number of experimental studies, mainly including drug treatment, cell transplantation, gene therapy, <i>etc</i>. Drug therapy includes traditional Chinese medicine, antioxidants, anti-apoptotic agents, neurotrophic factors, <i>etc</i>. Compared with other treatment methods, it is non-invasive and convenient and cheap, but its mechanism of action needs further research. Cell transplantation is considered an effective method for the treatment of retinitis pigmentosa, but it may cause preretinal membrane and macular folds. Although gene therapy has certain limitations, with the development of gene editing technology and new gene delivery vectors, it will become one of the most promising treatments for retinitis pigmentosa in the future. This article reviews and prospects the recent experimental research on retinitis pigmentosa.

8.
Article in English | WPRIM | ID: wpr-821234

ABSTRACT

@#BACKGROUND: Gastric lavage (GL) is one of the most critical early therapies for acute paraquat (PQ) poisoning; however, details of the treatment protocol remain to be established. METHODS: A rapid quantitative method involving sodium dithionite testing was developed. It was validated for the determination of the PQ concentrations in gastric juice and eluate samples from a swine acute PQ poisoning model with early or delay GL, or without. The vital signs, laboratory testing, and PQ plasma concentrations were collected for therapeutic effect evaluation. RESULTS: The reaction conditions of the test were optimized for two types of samples. Early GL at one hour (H1) could improve the signs and symptoms after acute PQ poisoning at 24 hours (H24). In contrast, GL at 6 hours (H6) could only partially relieve the vital signs. The H1 GL group effectively reduced the peak of the plasma PQ concentration. In addition, the PQ concentrations in the plasma and the gastric juice were signifi cantly decreased in both the GL groups as compared to the untreated group at H24. Moreover, there was no signifi cant difference in the washing effi ciencies calculated from the total eluates between the two GL groups. However, the washing effi ciency of the fi rst 10 L eluate is superior to that of the additional 10 L eluate. CONCLUSION: GL only at early stage may it benefit PQ poisoning in an animal model. The currently used 20 L GL volume may need to be reduced in view of the low washing efficiency in the later 10 L eluate. The rapid quantitative method can be used for gastric juice sample and has a certain value for clinical GL practices.

9.
Article in Chinese | WPRIM | ID: wpr-878803

ABSTRACT

In the current study, schisandrin B(SchB)-loaded F127 modified lipid-polymer hybrid nanoparticles(SchB-F-LPNs) were developed to improve the inhibition of breast cancer lung metastasis. Modified nanoprecipitation method was used to prepare SchB-F-LPNs. The nanoparticles were spherical in shape with shell-core structure by TEM observation. SchB-F-LPNs showed a mean particle size of(234.60±6.11) nm with zeta potential of(-5.88±0.49) mV. XRD results indicated that SchB existed in the nanoparticles in an amorphous state. The apparent permeability coefficient through porcine mucus of F-LPNs was 1.43-fold of that of LPNs as shown in the in vitro mucus penetration study. The pharmacokinetics study showed that the C_(max) of SchB was(369.06±146.94) μg·L~(-1),(1 121.34±91.65) μg·L~(-1) and(2 951.91±360.53) μg·L~(-1) respectively in SchB suspensions group, SchB-LPNs group and SchB-F-LPNs group after oral administration in rats. With SchB suspensions as the reference formulation, the relative bioavailability of SchB-F-LPNs was 568.60%. SchB-F-LPNs inhibited the morphological change during transforming growth factor-β1(TGF-β1)-induced epithelial-mesenchymal transition. In addition, SchB-F-LPNs significantly decreased the number of metastatic pulmonary nodules in 4 T1 tumor-bearing mice, suggesting that SchB-F-LPNs may inhibit the metastasis of breast cancer. These results reveal the promising potential of SchB-F-LPNs in treatment of breast cancer lung metastasis.


Subject(s)
Animals , Cyclooctanes , Lignans , Lipids , Lung Neoplasms/drug therapy , Mice , Nanoparticles , Polycyclic Compounds , Polyethylenes , Polymers , Polypropylenes , Rats , Swine
10.
International Eye Science ; (12): 970-973, 2020.
Article in Chinese | WPRIM | ID: wpr-876792

ABSTRACT

@#Retinitis pigmentosa is an inherited eye disease. The inheritance methods include autosomal dominant inheritance, autosomal recessive inheritance, and sex-linked recessive inheritance. Currently, there are more than 3,000 mutation sites, which makes clinical treatment of this disease difficult. Ophthalmologists are committed to exploring the treatment of retinitis pigmentosa, and have conducted a large number of experimental studies, mainly including drug treatment, cell transplantation, gene therapy, <i>etc</i>. Drug therapy includes traditional Chinese medicine, antioxidants, anti-apoptotic agents, neurotrophic factors, <i>etc</i>. Compared with other treatment methods, it is non-invasive and convenient and cheap, but its mechanism of action needs further research. Cell transplantation is considered an effective method for the treatment of retinitis pigmentosa, but it may cause preretinal membrane and macular folds. Although gene therapy has certain limitations, with the development of gene editing technology and new gene delivery vectors, it will become one of the most promising treatments for retinitis pigmentosa in the future. This article reviews and prospects the recent experimental research on retinitis pigmentosa.

11.
Article in Chinese | WPRIM | ID: wpr-872972

ABSTRACT

Nanocarriers for delivering active ingredients from Chinese materia medica play an important role in improving their solubility, membrane permeability and in vivo biological behavior, enhancing the therapeutic efficiency and reducing side effects. They are promising for extensive research and application. As novel nanocarriers, organic-inorganic hybrid nanocarriers composed of organic materials or carriers and inorganic parts possess the dual advantages of organic carriers and inorganic carriers. They may exert desirable action in drug delivery. In addition, they have been designed to improve the stability and biocompatibility, further increase the therapeutic efficiency and reduce side effects. They have also been investigated to achieve multi-functionality. In this paper, the research and application of organic-inorganic hybrid nanocarriers delivering active ingredients from Chinese materia medica were summarized and analyzed. The development and application prospect of organic-inorganic hybrid nanocarriers are prospected. The aim of this review is to provide a reference for the investigation of new drug delivery system for delivering active ingredients from Chinese materia medica efficiently and safely.

12.
Chinese Journal of Surgery ; (12): 85-90, 2020.
Article in Chinese | WPRIM | ID: wpr-787673

ABSTRACT

In the past two decades, with the introduction of NCCN guidelines, the establishment of a standardized diagnosis and treatment system for breast cancer had begun. The Chinese version of the NCCN guidelines, which combines international standards and Chinese characteristics, was then developed to guide clinical practice. Since 2011, Chinese experts have entered St. Gallen International Expert Consensus Group, and to introduce the latest therapy concepts. On this basis, the Chinese Society of Clinical Oncology has developed guidelines for diagnosis and treatment in line with product accessibility and expert opinions to help clinicians choose the best treatment option. The latest Chinese Society of Clinical Oncology Breast Cancer Guideline will further contribute to the establishment of a standardized diagnosis and treatment system for breast cancer.

13.
Chinese Journal of Surgery ; (12): 91-94, 2020.
Article in Chinese | WPRIM | ID: wpr-787672

ABSTRACT

Real-world study is increasingly becoming an important source of evidence for changing clinical practice, especially for clinical problems that can't be randomized. In recent years, real-world research in the field of breast cancer has gradually became a boom. Existing research results have begun to assist in the epidemiological analysis of breast cancer, promote the approval of rare diseases diagnosis and indication, and promote the analysis of real-world treatment status and evaluation of curative effects. Chinese scholars have also established databases and carried out relevant real-world research, providing real-world evidence for clinical practice in China. But domestic research is still in its infancy. The number of real-world research literature published by domestic scholars is relatively small, and there is a lack of pragmatic randomized clinical trial and real-world research for decision-making. In the future, we need to take advantage of the abundant diagnosis and treatment resources, further improve the database, and carry out real-world study on drug development based on population data in China.

14.
International Eye Science ; (12): 699-702, 2020.
Article in Chinese | WPRIM | ID: wpr-815760

ABSTRACT

@#AIM:To observe the correlation between the interleukin-1β(IL-1β)and interleukin-18(IL-18)in tears of patients with dry eye and symptoms and signs.<p>METHODS: A total of 131 patients(262 eyes)who were treated for dry eye in the ophthalmology clinic of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine were selected from September 2018 to December 12, and the patients were divided into dry eye classification standards according to the dry eye clinical consensus in 2013 No dry eye group, mild dry eye group, moderate dry eye group, severe dry eye group. All patients were examined for dry eye symptom score, break up time(BUT), and tear secretion test Schirmer I test(SⅠt), corneal fluorescein sodium staining(FL), ELISA method to detect the expression of IL-1β and IL-18 in tears, and to analyze the correlation between dry eye inflammatory factors and symptoms and signs.<p>RESULTS: There were significant differences in the expression of dry eye symptoms, BUT, SⅠt, FL and IL-1β and IL-18 in tears(<i>P</i><0.001), inflammatory factors IL-1β, IL-18 and dry eye symptom scores. FL was positively correlated(<i>P</i><0.05)and negatively correlated with BUT and SⅠt(<i>P</i><0.05).<p>CONCLUSION:Inflammatory factors in tears of dry eye patients were correlation with dry eye symptom and signsa.

15.
International Eye Science ; (12): 393-397, 2019.
Article in Chinese | WPRIM | ID: wpr-719736

ABSTRACT

@#Fundus blood vessels are the only terminal blood vessels that observed in the human body. Many diseases have pathological changes in fundus blood vessels. Through the study of these pathological changes, the fundus vascular changes can be used to diagnose diseases. This article summarizes some of the common pathological changes in fundus blood vessels. As well as the common diseases that cause these changes, it is hoped that some diseases can be associated with retinal vascular changes to facilitate the diagnosis of clinical diseases.

16.
Article in English | WPRIM | ID: wpr-771443

ABSTRACT

OBJECTIVE@#To explore the anti-nociceptive effect of patchouli alcohol (PA), the essential oil isolated from Pogostemon cablin (Blanco) Bent, and determine the mechanism in molecular levels.@*METHODS@#The acetic acid-induced writhing test and formalin-induced plantar injection test in mice were employed to confirm the effect in vivo. Intracellular calcium ion was imaged to verify PA on mu-opioid receptor (MOR). Cyclooxygenase 2 (COX2) and MOR of mouse brain were expressed for determination of PA's target. Cellular experiments were carried out to find out COX2 and MOR expression induced by PA.@*RESULTS@#PA significantly reduced latency period of visceral pain and writhing induced by acetic acid saline solution (P<0.01) and allodynia after intra-plantar formalin (P<0.01) in mice. PA also up-regulated COX2 mRNA and protein (P<0.05) with a down-regulation of MOR (P<0.05) both in in vivo and in vitro experiments, which devote to the analgesic effect of PA. A decrease in the intracellular calcium level (P<0.05) induced by PA may play an important role in its anti-nociceptive effect. PA showed the characters of enhancing the MOR expression and reducing the intracellular calcium ion similar to opioid effect.@*CONCLUSIONS@#Both COX2 and MOR are involved in the mechanism of PA's anti-nociceptive effect, and the up-regulation of the receptor expression and the inhibition of intracellular calcium are a new perspective to PA's effect on MOR.

17.
Article in Chinese | WPRIM | ID: wpr-801779

ABSTRACT

Objective: TO synthesize novel berberine derivatives with a variety of physiological activities,and study their antitumor activity and acetylcholinesterase inhibitory activity. Method: Berberines with a variety of physiological activities were pieced together isohydroxamic acid,o-phenylenediamine,and sulfhydryl pharmacophore with effects in inhibiting histones and removing acetylases. Totally 7 novel berberine derivatives were obtained by means of organic synthesis. The structures of these derivatives were characterized and confirmed by 1H-NMR,13 C-NMR and MS spectral data.Thiazolyl blue tetrazolium bromide(MTT) method was used in the determination of the cytotoxic activity of HCT116,HepG2,HeLa and CCRF-CEM human cancer cell lines in vitro. Ellman method was used to reveal the inhibitory activities of acetylcholinesterase and butyrylcholinesterase. Result: The results showed that the berberine derivatives containing methyl ketone had good antitumor and acetylcholinesterase inhibitory activities. The results demonstrated that compound 5b had the highest anti-proliferative activity against CCRF-CEM cell line and the acetylcholinesterase inhibitory activities, with IC50=1.48 μmol · L-1 and IC50=0.38 μmol · L-1,respectivly. Conclusion: This paper provides a reference for the synthesis and biological evaluation of this kind of alkaloid derivatives. Compound 5b is a promising candidate drug and worth further study.

18.
International Eye Science ; (12): 225-231, 2019.
Article in Chinese | WPRIM | ID: wpr-713001

ABSTRACT

@#AIM:To evaluate the efficacy of pranoprofen combined with sodium hyaluronate in treatment of dry eye in recent years by Meta-analysis.<p>METHODS: According to the Cochrane systematic review method, the computer searched Medline, EMbase, Cochrane Library, Wanfang database, Weipu database, China Knowledge Network database, and included in the randomized controlled study of pranoprofen combined with sodium hyaluronate in the treatment of dry eye in 2014-2018, RevMan5.3 statistical software for data extraction and Meta-analysis.<p>RESULTS: A total of 8 randomized controlled trials, all in Chinese, totally 1 008 patients. Meta-analysis showed that compared with the use of sodium hyaluronate alone, prano fraction combined with sodium hyaluronate significantly improved the BUT, SⅠt, FL, dry eye symptoms and overall efficacy of the patients, the difference was statistically significant.<p>CONCLUSION: The efficacy of pranoprofen combined with sodium hyaluronate in treatment of dry eye was better than that of sodium hyaluronate alone.

19.
Article in Chinese | WPRIM | ID: wpr-821747

ABSTRACT

Objective@#To find the differential expression profiles of circRNA in whole blood and predict its target genes in blood of patients with tuberculosis in Xinjiang, and explore the relationship between circRNA and the development of tuberculosis. @*Methods@#The circRNAs expression in peripheral blood from 3 pulmonary tuberculosis patients and 3 healthy individuals were tested by using circRNA microarray assay. The whole blood from 43 patients with tuberculosis, 40 healthy individuals and 43 patients with pneumonia were collected to verify the results by real-time quantitative PCR system. The possibility of differentially expressed circRNA target genes were predicted by circRNA target gene prediction database. @*Results@#In the results of microarray assay 835 circRNAs were found to be expressed differentially in whole blood between the tuberculosis patients and healthy controls of Xinjiang area, of which 249 circRNAs were up-regulated and 586 circRNAs were down-regulated in the patients. The expressions of four significantly different circRNA were verified by real time quantitative PCR and the results showed that hsa_circ_0008276, hsa_circ_0003452, hsa_circ_0001846 and hsa_circ_0090508 were down-regulated (P<0.05), and hsa_circ_0090508 was the more specific than the other three circRNAs. The results of circRNA target genes prediction suggested that has-miR-1294, has-miR-604, has-miR-616, has-miR-663b and has-miR-486-3p may be the potential target genes of hsa_circ_0090508. @*Conclusion@#The differentially expressed circRNA hsa_circ_0090508 was significantly downregulated in the patients with tuberculosis and may affect the regulation mechanism of tuberculosis through target genes.

20.
Article in Chinese | WPRIM | ID: wpr-816138

ABSTRACT

OBJECTIVE: To explore the relationship between chronic complications of type 2 diabetes mellitus(T2 DM)and obstructive sleep apnea syndrome(OSAS). METHODS: The data of 153 hospitalized T2 DM patients aged 40-65 years were collected; the demograhic data was recorded, biochemical indicators were recorded and analyzed, and the patients were screened for chronic complications of diabetes and OSAS. The patients with ketosis, acidosis and infection, and those who were addicted to alcohol,smoking or drug or with mental illness, or severe organ dysfunction were excluded.According to whether OSAS was combined, they were divided into the OSAS group and the control group were divided into groups. The differences in the incidence of chronic complications between the two groups were compared.Spearman correlation analysis was used to determine the relationship between chronic complications and OSAS.RESULTS: The incidence of diabetic peripheral neuropathy(DPN)in the OSAS group was higher than in the control group(45% vs. 26.9%, P=0.017). The incidence of coronary heart disease was significantly higher in the OSAS group than in the control group(20% vs. 8.6%, P=0.038). The differences were statistically significant.Spearman correlation analysis showed that OSAS was positively correlated with diabetic peripheral neuropathy(P=0.021)and coronary heart disease(P=0.041). CONCLUSION: OSAS may be associated with peripheral neuropathy and coronary heart disease in patients with T2 DM.

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