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2.
Rev. argent. cir ; 112(4): 407-413, dic. 2020. graf, il
Article in Spanish | LILACS, BINACIS | ID: biblio-1288149

ABSTRACT

RESUMEN La unión del tubo esofágico con el estómago en lo que denominamos el cardias, su tránsito y relacio nes con el hiato diafragmático, las estructuras fibromembranosas que la fijan y envuelven, la existencia de un esfínter gastroesofágico anatómico y su real morfología, así como la interacción de todos estos elementos, han sido materia de controversia por décadas y aún hoy. Este artículo actualiza la descrip ción de tales estructuras.


ABSTRACT The point where the esophagus connects to the stomach, known as the cardia, its transition and re lationship with the diaphragmatic hiatus, its fibromembranous attachments, the existence of an ana tomic gastroesophageal sphincter and its real morphology, and the interaction between all these ele ments, have been subject of debate for decades that still persist. The aim of this article is to describe the updated information of such structures.


Subject(s)
Diaphragm/physiology , Muscle Development , Esophagogastric Junction/physiology , Diaphragm/anatomy & histology , Esophagogastric Junction/anatomy & histology , Esophagogastric Junction/embryology
4.
Rev. cir. (Impr.) ; 72(1): 36-42, feb. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1092888

ABSTRACT

Resumen Introducción El uso del sistema de visión 3D en cirugía laparoscópica puede significar una mejor performance de los procedimientos quirúrgicos de mayor complejidad. Objetivo Reportar las indicaciones, los resultados y la valoración de un grupo de cirujanos de diferentes especialidades en el uso de visión 3D. Materiales y Método: Se analizan las indicaciones quirúrgicas y los resultados subjetivos y objetivos del uso del sistema óptico 3D (n = 155 pacientes) en cirugía laparoscópica compleja. Para evaluación subjetiva se aplicó a una encuesta de percepción cualitativa a los cirujanos participantes tipo Likert. Para la evaluación objetiva, se registran los tiempos quirúrgicos empleados en los diferentes procedimientos efectuados y las complicaciones postoperatorias y se comparan con los pacientes operados con sistema 2D (n = 783 pacientes) en el mismo periodo. Resultados el 70,6% concuerda tener mejor imagen con la técnica 3D, el 64,7% de los cirujanos refieren que se puede reducir el tiempo operatorio, el 58,8% considera que se puede reducir el error quirúrgico, el 92% y 100% respectivamente afirman que el confort del cirujano es mejor con el uso de óptica 3D y que esta técnica es recomendable para los procedimientos complejos. El tiempo operatorio se redujo en algunos procedimientos, especialmente urológicos. No se encontró diferencias sustanciales al comparar los resultados con el uso de sistema 3D versus 2D en cuanto a complicaciones postoperatorias. En la 3D no se encontró mortalidad postoperatoria, probablemente por el menor número de pacientes de ese grupo. Conclusión La laparoscopia 3D posee una buena valoración por los cirujanos que la emplearon, principalmente en calidad de imagen, reducción del tiempo operatorio y confort del cirujano en comparación con la laparoscopía 2D convencional. No se encontró diferencias sustanciales al comparar los resultados con el uso de sistema 3D versus 2D en cuanto a tiempo operatorio ni complicaciones postoperatorias.


Introduction The use of the 3D vision system in laparoscopic surgery can mean better performance in more complex surgical procedures. Aim Report the indications, results and assessment of a group of surgeons of different specialties in the use of 3D vision. Materials and Method Surgical indications and subjective and objective results of the use of 3D optical system in patients (n = 155) submitted to complex laparoscopic surgery are analyzed. Subjective evaluation based on a survey of qualitative perception (Likert) was applied to the participating surgeons. For objective evaluation, the operatory times and postoperative complications were recorded and compared with the results observed with the use of the 2D system (783 patients) in the same period. Results 70.6% agree to have a better image with the 3D technique, 64.7% of surgeons report that the operative time can be reduced, 58.8% consider that it can be reduced the surgical error, 92% and 100% respectively considered that the comfort of the surgeon is better with the use of 3D optics and that this technique is recommended for complex procedures. No substantial differences were found when comparing the results with the use of 3D versus 2D system by the same surgical teams in terms of operative times and postoperative complications. In 3D, postoperative mortality was probably not found due to the lower number of patients in this group. Conclusion 3D laparoscopy has a good evaluation by the surgeons who used it, mainly in image quality, reduction of operative time and comfort of the surgeon compared to conventional 2D laparoscopy. No substantial differences were found when comparing the results with the use of 3D versus 2D system in terms of operative times or postoperative complications.


Subject(s)
Humans , Laparoscopy/methods , Imaging, Three-Dimensional/methods , Chile , Surveys and Questionnaires , Laparoscopy/statistics & numerical data , Imaging, Three-Dimensional/instrumentation , Surgery, Computer-Assisted/methods , Comparative Effectiveness Research , Operative Time
5.
ABCD arq. bras. cir. dig ; 33(3): e1547, 2020. tab, graf
Article in English | LILACS | ID: biblio-1152619

ABSTRACT

ABSTRACT Background: The identification of prognostic factors of esophageal cancer has allowed to predict the evolution of patients. Aim: Assess different prognostic factors of long-term survival of esophageal cancer and evaluate a new prognostic factor of long-term survival called lymphoparietal index (N+/T). Method: Prospective study of the Universidad de Chile Clinical Hospital, between January 2004 and December 2013. Included all esophageal cancer surgeries with curative intent and cervical anastomosis. Exclusion criteria included: stage 4 cancers, R1 resections, palliative procedures and emergency surgeries. Results: Fifty-eight patients were included, 62.1% were men, the average age was 63.3 years. A total of 48.3% were squamous, 88% were advanced cancers, the average lymph node harvest was 17.1. Post-operative surgical morbidity was 75%, with a 17.2% of reoperations and 3.4% of mortality. The average overall survival was 41.3 months, the 3-year survival was 31%. Multivariate analysis of the prognostic factors showed that significant variables were anterior mediastinal ascent (p=0.01, OR: 6.7 [1.43-31.6]), anastomotic fistula (p=0.03, OR: 0.21 [0.05-0.87]), N classification (p=0.02, OR: 3.8 [1.16-12.73]), TNM stage (p=0.04, OR: 2.8 [1.01-9.26]), and lymphoparietal index (p=0.04, RR: 3.9 [1.01-15.17]. The ROC curves of lymphoparietal index, N classification and TNM stage have areas under the curve of 0.71, 0.63 and 0.64 respectively, with significant statistical difference (p=0.01). Conclusion: The independent prognostic factors of long-term survival in esophageal cancer are anterior mediastinal ascent, anastomotic fistula, N classification, TNM stage and lymphoparietal index. In esophageal cancer the new lymphoparietal index is stronger than TNM stage in long-term survival prognosis.


RESUMO Racional: A identificação de fatores prognósticos do câncer de esôfago permitiu prever a evolução dos pacientes. Objetivo: Avaliar diferentes fatores prognósticos da sobrevida em longo prazo do câncer de esôfago e avaliar um novo fator prognóstico da sobrevida em longo prazo chamado índice linfoparietal (N+/T). Método: Estudo prospectivo do Hospital Clínico da Universidade do Chile, entre janeiro de 2004 e dezembro de 2013. Incluiu todas as operações de câncer de esôfago com intenção curativa e anastomose cervical. Os critérios de exclusão incluíram: câncer em estágio 4, ressecções R1, procedimentos paliativos e operações de emergência. Resultados: Cinquenta e oito pacientes foram incluídos, 62,1% eram homens, a idade média foi de 63,3 anos. Um total de 48,3% eram escamosos, 88% eram cânceres avançados, a colheita média de linfonodos foi de 17,1. A morbidade cirúrgica pós-operatória foi de 75%, com 17,2% de reoperações e 3,4% de mortalidade. A sobrevida global média foi de 41,3 meses, a sobrevida em três anos foi de 31%. A análise multivariada dos fatores prognósticos mostrou que variáveis significativas foram elevação pelo mediastinal anterior (p=0,01, OR: 6,7 [1,43-31,6]), fístula anastomótica (p=0,03, OR: 0,21 [0,05-0,87]), classificação N (p=0,02, OR: 3,8 [1,16-12,73]), estágio TNM (p=0,04, OR: 2,8 [1,01-9,26]) e índice linfoparietal (p=0,04, RR: 3,9 [1,01-15,17]. As curvas ROC do índice linfoparietal, classificação N e estádio TNM apresentam áreas abaixo da curva de 0,71, 0,63 e 0,64, respectivamente, com diferença estatística significativa (p=0,01). Conclusão: Os fatores prognósticos independentes de sobrevida em longo prazo no câncer de esôfago são a elevação mediastinal anterior, fístula anastomótica, classificação N, estágio TNM e índice linfoparietal. No câncer de esôfago, o novo índice linfoparietal é mais forte que o estágio TNM no prognóstico de sobrevida em longo prazo.


Subject(s)
Humans , Male , Female , Middle Aged , Esophageal Neoplasms/mortality , Esophageal Neoplasms/pathology , Esophagectomy/methods , Cancer Survivors/statistics & numerical data , Esophageal Squamous Cell Carcinoma/mortality , Esophageal Squamous Cell Carcinoma/pathology , Lymph Nodes/pathology , Prognosis , Esophageal Neoplasms/surgery , Chile/epidemiology , Survival Rate , Prospective Studies , Survivors , Esophageal Squamous Cell Carcinoma/surgery , Lymph Node Excision , Neoplasm Staging
6.
Rev. cir. (Impr.) ; 71(2): 111-117, abr. 2019. tab
Article in Spanish | LILACS | ID: biblio-1058242

ABSTRACT

INTRODUCCIÓN: Los datos sobre número de operaciones realizadas en Chile en patología del intestino proximal y glándulas anexas, han sido cada vez más precisas en los registros estadísticos del MINSAL en los últimos años. OBJETIVO: a) Incorporar datos de otras operaciones no incluidas en reportes previos, b) comparar los resultados de operaciones de alta complejidad reportadas el año 2011 y confrontarlos con los datos del año 2016. MATERIAL Y MÉTODO: En el DEIS (Departamento de Estadística e Información de Salud) se obtuvo el número total de operaciones realizadas en Chile el año 2016 y mortalidad operatoria al momento del egreso de diferentes patologías del intestino proximal y glándulas anexas, siendo la mayoría tumores malignos: cáncer de esófago, estómago, páncreas, hígado y vías biliares intrahepáticas y vesícula biliar. Los resultados se compararon con los obtenidos del año 2011. RESULTADOS: La letalidad anual de cánceres digestivos demostró un alza del cáncer de páncreas e hígado, mientras que se aprecia una baja en el cáncer de esófago y vesícula biliar. Operaciones de patología benigna, como la esofagocardiomiotomía y cirugías antirreflujo laparoscópica no mostraron mortalidad, al igual que el bypass gástrico. La colecistectomía y la gastrectomía vertical laparoscópicas, tuvieron una muy baja mortalidad operatoria. En las intervenciones quirúrgicas por tumores malignos se apreció en todos una disminución de la mortalidad operatoria comparado con el año 2011, aunque no fue estadísticamente significativo. CONCLUSIÓN: El presente estudio muestra un aumento de las operaciones por enfermedades del intestino proximal y glándulas anexas así como una disminución de la mortalidad operatoria el año 2016 comparado con el 2011.


INTRODUCTION: The number of operations performed in Chile due to diseases for the foregut, have been every time more precise and complete in the National Register Data of Statistics in Health (MINSAL), and published in several reports (years 1983, 2005 and 2011). OBJECTIVES: a) to incorporate data of new operations not included before and b) to compare the results of high complex operations reported on 2011 and 2016. MATERIAL AND METHODS: from the DEIS (Department of Statistics and Information of Health) we obtained the total number of operations performed during 2016, and the operative mortality at the time of discharge from the hospital for different diseases of the foregut been the majority malignant tumors: esophageal cancer, gastric cancer, pancreatic cancer, liver and bile ducts carcinoma, and cancer of the gallbladder. The results were compared to dose obtained the year 2011. RESULTS: The annual lethality of digestive malignant tumors showed an increase in pancreatic and liver cancer, while a decrease was observed in patients with esophageal cancer al gallbladder cancer. Operations for benign pathology like esophagomiotomy and laparoscopic antireflux surgery showed no mortality, as well as gastric bypass. Laparoscopic cholecistectomy, and laparoscopic sleeve gastrectomy presented a very low mortality. Surgical procedures for malignant diseases showed a decrease in operative mortality compare to 2011, although not significant. CONCLUSIONS: The present study shows an increase in the operations for foregut diseases performed during 2016 compared with the year 2011, as well as a decrease in operative mortality.


Subject(s)
Humans , Digestive System Surgical Procedures/statistics & numerical data , Digestive System Diseases/surgery , Digestive System Surgical Procedures/mortality , Chile/epidemiology , Cross-Sectional Studies , Digestive System Neoplasms/surgery
7.
Rev. chil. cir ; 71(1): 47-54, feb. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-985378

ABSTRACT

Resumen Introducción: Existe una tendencia global al envejecimiento y con ello un aumento de patologías asociadas. En Chile la prevalencia de la colelitiasis o colecistolitiasis aumenta con la edad, siendo la cole-cistectomía una de las cirugías más frecuentes. Existen escasos estudios latinoamericanos referentes a la realidad de la población octogenaria expuesta a este problema. Objetivo: Estudiar la morbimortalidad posoperatoria en pacientes octogenarios operados de colecistectomía. Definir la precisión de distintas herramientas diagnósticas preoperatorias, estudiar variables operatorias y precisar costos hospitalarios. Materiales y Método: Estudio observacional retrospectivo de la ficha clínica electrónica del Hospital Clínico de la Universidad de Chile, entre enero de 2012 y mayo de 2017. Se incluyeron pacientes con edad igual o mayor a 80 años, en quienes se realizó una colecistectomía electiva o de urgencia por patología benigna. Resultados: Se incluyeron 145 pacientes, 51,7% fueron mujeres, el promedio de edad fue de 84,1 años y un 74,5% presentaba comorbilidades. El 62,1% de los casos ingresó por urgencia. 26,2% de toda la muestra presentó coledocolitiasis. La colecistectomía fue laparoscópica en 73,8% de la muestra global, la tasa de conversión fue de 14,5% en población de urgencia y 1,8% en población electiva (p = 0,009). La población operada totalmente por vía laparoscópica con coledocolitiasis fue resuelta en un 95,2% a través de Rendez-vous, con una tasa de éxito del 100%. La tasa de complicaciones fue de 17,9% siendo en su mayoría médicas, la mortalidad quirúrgica fue de 2,1%, siendo todos casos de urgencia. El costo promedio de atención en salud hospitalaria fue de $5.888.104 pesos chilenos (U$9.000). Conclusión: El paciente octogenario con colecistolitiasis representa un desafío quirúrgico, dado un mayor número de comorbilidades, un cuadro clínico más agresivo y una elevada tasa de coledocolitiasis. Es aconsejable valorar el abordaje mínimamente invasivo y realizar una colangiografía intraoperatoria de rutina.


Introduction: There is a global tendency to aging and associated pathologies. In Chile, the prevalence of cholecystolithiasis increases with age, cholecystectomy is one of the most frequent surgeries in the contry. There are few latinamerican studies regarding the reality of the elderly exposed to this problem. Objective: Study postoperative morbimortality in octogenarian patients undergoing cholecystectomy. Define the accuracy of different preoperative diagnostic tools, study operative variables and specify hospital costs. Materials and Method: Retrospective observational study of the Clinical Hospital of the University of Chile, between January 2012 and May 2017. Patients with age equal to or greater than 80 years were included, in whom an elective or emergency cholecystectomy was performed for benign pathology. Results: A total of 145 patients were included, 51.7% were women, the average age was 84.1 years, and 74.5% had comorbidities. The admission was throw the emergency department in 62.1% of the cases. Choledocholithiasis was diagnosed in 26.2% of the entire sample. Cholecystectomy was fully laparoscopic in 73.8% of the overall sample, the conversion rate was 14.5% in the emergency population and 1.8% in the elective population (p = 0.009). The population operated fully laparoscopically, that had choledocholithiasis, was resolved in 95.2% through Rendezvous technique, with a 100% clearance rate of common bile duct. The complication rate was 17.9%, most being medical. The surgical mortality was 2.1%, all cases operated from emergency. The average cost of hospital health care was $5,888,104.3 Chilean pesos (U$9.000). Conclusion: The octogenarian patient with cholecystolithiasis represents a surgical challenge, given a greater number of comorbidities, a more aggressive clinical setting and a high rate of choledocolithiasis. It is advisable to assess the minimally invasive approach and perform routine intraoperative cholangiography. In the postoperative period, the cardiopulmonary status and the infectious complications of the surgical site should be monitored closely.


Subject(s)
Humans , Male , Female , Aged, 80 and over , Choledocholithiasis/surgery , Choledocholithiasis/diagnosis , Choledocholithiasis/etiology , Gallstones/surgery , Retrospective Studies , Cholecystectomy, Laparoscopic , Laparoscopy/methods
8.
ABCD arq. bras. cir. dig ; 32(2): e1441, 2019. tab, graf
Article in English | LILACS | ID: biblio-1019242

ABSTRACT

ABSTRACT Background: The identification of prognostic factors of gastric cancer (GC) has allowed to predict the evolution of patients. Aim: Assess the reliability of the lymphoparietal index in the prediction of long-term survival in GC treated with curative intent. Method: Prospective study of the Universidad de Chile Clinical Hospital, between May 2004 and May 2012. Included all gastric cancer surgeries with curative intent. Exclusion criteria were: gastrectomies due to benign lesions, stage 4 cancers, R1 resections, palliative procedures, complete esophagogastrectomies and emergency surgeries. Results: A total of 284 patients were included; of the sample 65.4% were male,mean age of 64.5 years,75% were advanced cancers, 72.5% required a total gastrectomy, 30 lymph nodes harvest. Surgical morbidity and mortality were 17.2% and 1.7%. 5-year survival was 56.9%. The N+/T index could predict long-term survival in all de subgrups (p<0.0001), although had a reliable prediction in early GC (p=0.005), advanced GC (p<0.0001), signet ring cell GC (p<0.0001), proximal GC (p<0.0001) and distal GC (p<0.0001). The ROC curves N+/T index, LNR and T classification presented areas below the curve of 0.789, 0.786 and 0,790 respectively, without a significant statistical difference (p=0.96). Conclusion: The N+/T index is a reliable quotient in the prognostic evaluation of gastric adenocarcinoma patients who have been resected with curative intent.


RESUMO Racional: A identificação de fatores prognósticos do câncer gástrico (GC) permitiu predizer a evolução dos pacientes. Objetivo: Avaliar a confiabilidade do índice linfoparietal na predição de sobrevida em longo prazo em pacientes tratados com intenção curativa. Método: Estudo prospectivo do Hospital das Clínicas da Universidade de Chile, entre maio de 2004 e maio de 2012. Todas as operações de câncer gástrico foram com intenção curativa. Os critérios de exclusão foram: gastrectomia por lesões benignas, cânceres estágio 4, ressecções R1, procedimentos paliativos, esofagogastrectomias completas e operações de emergência. Resultados: Foi incluído um total de 284 pacientes; da amostra 65,4% eram homens, com média de idade de 64,5 anos, 75% eram cânceres avançados, 72,5% necessitaram de gastrectomia total e 30 coletas de linfonodos. A morbimortalidade cirúrgica foi de 17,2% e 1,7%. Sobrevida em cinco anos foi de 56,9%. O índice N +/T pôde predizer a sobrevida em longo prazo em todos os subgrupos (p<0,0001), embora tivesse previsão confiável em GC precoce (p=0,005), GC avançado (p<0,0001), célula GC de anel de sinete (p< 0,0001), GC proximal (p<0,0001) e GC distal (p<0,0001). As curvas ROC N +/T, LNR e T apresentaram áreas abaixo da curva de 0,789, 0,786 e 0,790, respectivamente, sem diferença estatística significativa (p=0,96 ). Conclusão: O índice N +/T é um quociente confiável no prognóstico na avaliação de pacientes com adenocarcinoma gástrico que foram ressecados com intenção curativa.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Stomach Neoplasms/mortality , Lymph Nodes/pathology , Prognosis , Stomach Neoplasms/surgery , Stomach Neoplasms/pathology , Prospective Studies , Reproducibility of Results , Disease-Free Survival , Gastrectomy , Neoplasm Staging
9.
Rev. chil. cir ; 70(3): 266-272, 2018. ilus
Article in Spanish | LILACS | ID: biblio-959381

ABSTRACT

Resumen Introducción Los pacientes sometidos a desconexión total con cierre al nivel del seno piriforme debido a necrosis completa del esófago y estómago después de la ingestión cáustica representan un desafío quirúrgico para restablecer la ingestión oral y la calidad de vida. Objetivo El objetivo de este trabajo es presentar la experiencia con un caso clínico con necrosis total de esófago y estómago posingestión de cáuticos por lo que fue inicialmente sometido a esofagectomía y gastrectomía total. Método La reconstrucción del tracto digestivo superior se efectuó mediante una faringo-íleo-colo anastomosis, con suplemento de irrigación sanguínea arterial y drenaje venoso mediante técnica de anastomosis microquirúrgica. Resultados No se observaron complicaciones postoperatorias mayores y en el resultado a largo plazo se logra alimentación oral normal con una recuperación nutricional adecuada y buena calidad de vida. Conclusión Esta es un procedimiento a plantear en pacientes con estenosis faríngea sin posibilidad de reemplazo esofágico con procedimientos menos complejos.


Introduction Patients submitted to total esophagectomy and gastrectomy with complete closure of pharinx due to necrosis after caustic ingestion are a challenging surgical setting for reconstruction of upper digestive transit. Objective The objective of this paper is to present a clinical case and surgical technique for reconstruction of the upper digestive tract after total esophagectomy and gastrectomy. Method Reconstruction of digestive transit was reestablished by means of a pharyngo-ileo-colonic interposition with microsurgical arterial and venous anastomosis for augmentation of blood supply. Results There were not major postoperative complications and at long term follow-up, normal oral nutrition and quality of life improvement was observed. Conclusion This is a surgical procedure for treatment of patients with pharyngeal strictures without any possibility to indicate other less complex procedures.


Subject(s)
Humans , Male , Adult , Anastomosis, Surgical/methods , Colon/transplantation , Reconstructive Surgical Procedures/methods , Esophageal Diseases/surgery , Caustics , Esophagectomy/methods , Colon/blood supply , Esophageal Diseases/chemically induced , Microsurgery , Necrosis
10.
Rev. chil. cir ; 70(2): 147-159, 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-959363

ABSTRACT

Resumen Introducción: La identificación de factores pronósticos del cáncer gástrico, ha permitido predecir la evolución de los pacientes y así tomar decisiones terapéuticas. En Chile existe un déficit en el análisis de factores pronósticos de sobrevida alejada. Objetivos: Los objetivos de este estudio fueron: evaluar distintos factores pronósticos de sobrevida alejada en cáncer gástrico, determinar la tasa de sobrevida global mayor a 5 y 10 años posoperatoria tanto en cánceres incipientes como avanzados y evaluar el valor de un nuevo factor pronóstico de sobrevida alejada denominado N+/T. Material y Método: Estudio prospectivo de la base de datos oncológica del Hospital Clínico de la Universidad de Chile entre mayo de 2004 y mayo de 2012. Resultados: Se incluyeron un total de 284 pacientes, 65,4% fueron hombres, la edad media fue 64,5 años. 75% de la muestra fueron cánceres avanzados, 72,5% de los pacientes requirieron una gastrectomía total. La linfadenectomía practicada fue D2 en un 85,2%. La cosecha linfononodal global media fueron 30 linfonodos. La morbilidad y mortalidad quirúrgica posoperatoria fue de 17,2% y 1,7% respectivamente. La sobrevida global media fue de 69,9 meses, la sobrevida a 5 años fue de 56,9% y la sobrevida a 10 años fue de 53,4%. Al analizar el índice N+/T, se identifica una diferencia estadísticamente significativa en la sobrevida global alejada de todos los subgrupos (p < 0,0001). El análisis multivariado de los factores pronósticos objetiva que las variables significativas son: índice N+/T (p = 0,0001, OR: 1,1 [1,05-1,12]), LNR (p = 0,0001, OR: 5,8 [1,04-15,6]), edad (p = 0,008, OR: 1,03 [1,00-1,06]), permeación linfovascular (p = 0,0001, OR: 2,19 [1,49-3.23]), clasificación T (p = 0,03, OR: 3,4 [1,10-8,93]), clasificación N (p = 0,001, OR: 1,06 [1,02-1,10]) y estadio TNM (p = 0,004, OR: 1,03 [1,01-1,06]). Las curvas ROC del índice N+/T, LNR y clasificación T poseen áreas bajo la curva de 0,789, 0,786 y 0,790 respectivamente, sin diferencia estadística significativa (p = 0,96). Conclusión: Los factores pronósticos independientes de sobrevida mayor a 5 años son: índice N+/T, LNR, edad, permeación linfovascular, clasificación T, clasificación N y estadio TNM. Concomitantemente se ha logrado aportar un nuevo cuociente pronóstico en la evaluación de pacientes con adenocarcinoma gástrico resecados con intención curativa, el índice N+/T.


Background: The identification of survival prognostic factors for gastric cancer, allows us to create clinical guidelines. Chile has a deficit in the analysis of long-term survival prognostic factors. Aim: To assess different prognostic factors of long-term survival in gastric cancer. Determine the survival rate at 5 and 10-years post gastrectomy, and the value of a new prognostic factor of long-term survival called N+/T. Material and Method: Prospective study of the oncological database of the Clinical Hospital of the University of Chile between May 2004 and May 2012. Results: A total of 284 patients were included, 65.4% were men and the mean age was 64.5 years. Seventy-five percent were advanced gastric cancer, 72.5% of the patients required a total gastrectomy. The lymphadenectomy practiced was D2 in 85.2%, and average lymph node harvest was 30 lymph nodes. The postoperative morbidity and mortality was 17.2% and 1.7% respectively. The average global survival was 69.9 months, the 5-year survival was 56.9% and the 10-year survival was 53.4%. The N+/T index presented a statistically significant difference in the global survival of all the subgroups (p < 0.0001). The multivariate analysis showed that the significant variables were: N+/T index (p = 0.0001, OR: 1.1 [1.05-1.12]), LNR (p = 0.0001, OR: 5.8 [1.04-15.6]), age (p = 0.008, OR: 1.03 [1.00-1.06]), lymphovascular permeation (p = 0.0001, OR: 2.19 [1.49-3.23]), T classification (p = 0.03, OR: 3.4 [1.10-8.93]), N classification(p = 0.001, OR: 1.06 [1.02-1.10]), and TNM stage (p = 0.004, OR: 1.03 [1.01-1.06]). The areas under the ROC curves of the N+/T, LNR and T classification, were 0.789, 0.786 and 0.790 respectively (p = 0.96). Conclusion: The independent prognostic factors of long-term survival were N+/T index, LNR, age, lymphovascular permeation, T classification, N classification and TNM stage. Concomitantly, a new prognostic factor has been created to assess survival in gastric cancer, the N+/T index.


Subject(s)
Humans , Male , Female , Stomach Neoplasms/surgery , Stomach Neoplasms/mortality , Gastrectomy/methods , Prognosis , Survival Analysis , Multivariate Analysis , Prospective Studies , ROC Curve , Gastrectomy/mortality , Lymph Node Excision , Lymphatic Metastasis , Neoplasm Staging
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