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1.
ABCS health sci ; 47: e022207, 06 abr. 2022. ilus, tab
Article in English | LILACS | ID: biblio-1372363

ABSTRACT

INTRODUCTION: Several studies have shown that early mobilization is safe and beneficial for patients admitted to the intensive care units (ICUs), especially for those with mechanical ventilation (MV). OBJECTIVE: To investigate the benefits of early mobilization physiotherapeutic techniques applied to patients who suffered craniocerebral trauma (CCT). METHODS: This is an experimental study that evaluated clinical data from 27 patients. In sedated patients, mobilization and passive stretching were performed on the upper and lower limbs; in those without sedation, active-assisted, free and resisted exercises were included. RESULTS: The experimental group was composed of 51.8% of the participants and the control group by 48.2%, the majority being male (81.5%) with a median age of 43 years. The patients in the experimental group had an average of 9.5 days (2.2-14.7) of mechanical ventilation (MV), and those belonging to the control group, of 17 days (7-21.7) with MV (p=0.154). The patients in the experimental group had an average of 13.5 days in the ICU, against an average of 17 days in the control group (p=0.331), and an average of 20.5 days in hospital against 24 days in the control group (p=0.356). CONCLUSION: Early mobilization should be applied to critically ill patients as it can decrease the length of stay in the ICU and the hospital.


INTRODUÇÃO: Diversos estudos têm mostrado que a mobilização precoce é segura e benéfica para pacientes internados em unidades de terapia intensiva (UTIs), especialmente para aqueles com ventilação mecânica (VM). OBJETIVO: Investigar os benefícios das técnicas fisioterapêuticas de mobilização precoce aplicada aos pacientes que sofreram traumatismo cranioencefálico (TCE). MÉTODOS: Trata-se de um estudo quasi-randomizado, que incluiu 27 com TCE divididos em dois grupos: controle (n=13) e experimental (n=14) pacientes. No grupo experimental, os pacientes sedados foram submetidos à mobilização e alongamentos passivos nos membros superiores e inferiores; naqueles sem sedação, foram incluídos exercícios ativo-assistidos, livres e resistidos. RESULTADOS: O grupo experimental foi composto por 51,8% dos participantes da pesquisa e o grupo controle por 48,2%, sendo a maioria do sexo masculino (81,5%) com mediana de idade de 43 anos. Os pacientes do grupo experimental apresentaram média de 9,5 dias (2,2-14,7) de ventilação mecânica, e os pertencentes ao grupo controle, de 17 dias (7-21,7) com de VM (p=0,154). Os pacientes do grupo experimental apresentaram média de 13,5 dias de internação em UTI, contra média de 17 dias do grupo controle (p=0,331), e média de 20,5 dias de internação hospitalar contra 24 dias do grupo controle (p=0,356). CONCLUSÃO: A mobilização precoce é uma técnica que deve ser aplicada em pacientes críticos dentro das UTIs, pois pode diminuir o tempo de internação na UTI e hospitalar.


Subject(s)
Humans , Male , Female , Physical Therapy Department, Hospital , Early Ambulation , Brain Injuries, Traumatic/therapy , Intensive Care Units , Hospitals, State
2.
Rev. Assoc. Med. Bras. (1992) ; 68(4): 482-489, Apr. 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1376145

ABSTRACT

SUMMARY OBJECTIVE: The aim of this study was to assess the quality of primary health care services through self-reports by caregivers of children and adolescents living in quilombola communities in Brazil. METHODS: This is a cross-sectional study in accordance with the STROBE (STrengthening the Reporting of OBservational studies in Epidemiology). Exposure variables included sociodemographic characteristics; and outcome variable was the quality of primary health care offered to quilombola children and adolescents. RESULTS: A total of 68 individuals participated in the survey. Quilombolas have a low income, a lower level of education, do not work, and receive government benefits. Our results showed that the quality of primary health care, measured by the experience of caregivers of quilombola children and adolescents, generally presents satisfactory values. CONCLUSION: The quality of primary health care has generally satisfactory values. However, as these results differ from most studies, more research should be conducted.

3.
J. Bras. Patol. Med. Lab. (Online) ; 58: e4152022, 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1375703

ABSTRACT

ABSTRACT Lung cancer is the first in terms of incidence and mortality, being responsible worldwide for about 1.8 million deaths. In Brazil 31,270 new cases were diagnosed in 2018, 18,740 in men and 12,350 in women. One of the main challenges about lung cancer is performing an early diagnosis, in most cases the disease is detected in the late stages, which implies in poor prognoses. Tumor biomarkers are hugely relevant in early diagnosis, understanding of carcinogenesis, prognostic determination and therapeutic choice. The present paper reviews non-small cell lung cancer biomarkers described in the literature and their diagnostic, prognostic and therapeutic applications, intervention and therapeutic control for individualized therapy. Although there is still a vast universe to be explored, studies reveal a promising future for lung cancer treatment with increasingly personalized and assertive therapies that increase the chances of progression-free survival.


RESUMO O câncer de pulmão é o primeiro em incidência e mortalidade, sendo responsável mundialmente por cerca de 1,8 milhão de mortes. No Brasil, 31.270 casos novos foram diagnosticados em 2018, sendo 18.740 em homens e 12.350 em mulheres. Um dos principais desafios do câncer de pulmão é o diagnóstico precoce, na maioria das vezes a doença é detectada em fases tardias, o que implica em mau prognóstico. Os biomarcadores tumorais são extremamente relevantes no diagnóstico precoce, compreensão da carcinogênese, determinação do prognóstico e escolha terapêutica. O presente trabalho revisa biomarcadores de câncer de pulmão de células não pequenas descritos na literatura e suas aplicações diagnósticas, prognósticas e terapêuticas, intervenção e controle terapêutico para terapia individualizada. Embora ainda exista um vasto universo a ser explorado, estudos revelam um futuro promissor para o tratamento do câncer de pulmão com terapias cada vez mais personalizadas e assertivas que aumentam as chances de sobrevida livre de progressão.

4.
J. Hum. Growth Dev. (Impr.) ; 31(3): 476-483, Sep.-Dec. 2021. graf, map, tab
Article in English | LILACS, INDEXPSI | ID: biblio-1356367

ABSTRACT

INTRODUCTION: With the arrival of the SARS-CoV-2 (Coronavirus 2 of severe acute respiratory syndrome) pandemic in Brazil, especially in the city of São Paulo, there was a need to apply social isolation policies associated with testing, covering all municipalities. The Clinical Analysis Laboratory of Centro Universitário FMABC was one of the first laboratories to receive certification and qualification to perform RT-PCR (reverse transcriptase reaction followed by polymerase chain reaction) tests in the metropolitan region of São Paulo OBJECTIVE: Aim to analyze the influence of adopting social isolation on the incidence of positivity in COVID-19 tests in the metropolitan region of São Paulo, Brazil METHODS: a descriptive study carried out from March to May 2020, epidemiological data were collected from each unit served and organized by the data controllership team of the Clinical Analysis Laboratory of FMABC. Epidemiological, demographic, and laboratory data were extracted from the Matrix® outpatient data management system. Clinically suspected cases and confirmed by laboratory tests (RT-PCR and serological tests) were entered. The tests were divided into serological tests using the RT-PCR molecular test, on samples of nasopharyngeal mucosal scrapings collected with sterile Swab RESULTS: It were evaluated PCR test and antibody presence (IgA, IgM and IgG) in blood samples of 16.297 patients. 22.718 tests were performed for the diagnosis of COVID-19, both RT-PCR (10.410 tests) and serological tests to detect anti-SARS-CoV-2 antibodies, IgA, IgM and IgG, a total of 16.297 patients were assessed, 63% women and 37% men. It was observed that the social isolation policies adopted during this period contained the massive expansion of contamination, at least while the social isolation rates were above 55% CONCLUSION: The data of this study demonstrated the effectiveness of social isolation in containing the positive contamination of SARS-CoV-2 in the metropolitan region of São Paulo, at least for the first three months


INTRODUÇÃO: com a chegada da pandemia de SARS-CoV-2 (Coronavirus 2 da síndrome respiratória aguda grave) ao Brasil, especialmente na cidade de São Paulo, houve a necessidade de aplicar medidas de distanciamento social associado a testagem, que abrangesse todos os municípios. A região metropolitana de São Paulo compreende 39 municípios e possui uma rede de laboratórios habilitados a realizar a testagem para a detecção do coronavírus, tanto testes sorológicos quanto moleculares. O Laboratório de Análises Clínicas do Centro Universitário ABC/FMABC foi um dos primeiros laboratórios a receber a certificação e habilitação para realizar os testes RT-PCR (reação da transcriptase reversa seguida pela reação em cadeia da polimerase) na região metropolitana de São Paulo OBJETIVO: analisar a influência da adoção do isolamento social na incidência de positividade nos testes de COVID-19 em região metropolitana de São Paulo, Brasil MÉTODO: estudo descritivo realizado no período de março a maio de 2020, os dados epidemiológicos foram coletados de cada unidade atendida e organizada pela equipe de controladoria de dados do Laboratório de Análises Clínicas da FMABC. Os dados epidemiológicos, demográficos e laboratoriais foram extraídos do sistema Matrix® de gerenciamento de dados ambulatoriais. Foram inseridos os casos clinicamente suspeitos e confirmados por testes de laboratório (RT-PCR e testes sorológicos). Os testes foram divididos em testes sorológicos no teste molecular RT-PCR, em amostras de raspado de mucosa nasofaríngea coletada com Swab estéril RESULTADOS: foram avaliados o teste de RT-PCR e a presença de anticorpos (IgA, IgM e IgG) em amostras de sangue de 16.297 pacientes. Foram realizados 22.718 testes para o diagnóstico de COVID-19, tanto RT-PCR (10.410 testes), quanto testes sorológicos para detecção de anticorpos anti-SARS-CoV-2, IgA, IgM e IgG, um total de 16.297 pacientes foram avaliados, 63% mulheres e 37% homens. Observou-se que as políticas de isolamento social adotadas nesse período continham a expansão massiva da contaminação, pelo menos enquanto as taxas de isolamento social eram superiores a 55% CONCLUSÃO: nossos dados demonstraram a efetividade do isolamento social na retenção da positividade da contaminação do SARS-CoV-2 nas cidades contempladas pelo serviço de testagem do Centro Universitário Saúde ABC, pelo menos nos três primeiros meses


Subject(s)
Social Isolation , Serologic Tests , Pandemics , COVID-19 Nucleic Acid Testing , COVID-19 , COVID-19/epidemiology
5.
J. Hum. Growth Dev. (Impr.) ; 31(2): 310-317, May-Aug. 2021.
Article in English | LILACS, INDEXPSI | ID: biblio-1340090

ABSTRACT

INTRODUCTION: Due to the high incidence and mortality rates that cancer has, the World Health Organization (WHO) defines it as a public health problem and points out that there are approximately 10 million people affected by cancer, the estimate for the year 2020 will be 16 million of sick individuals.One of the most frequent neoplasms in the world, Prostate Cancer (CaP) (1.1 million), occupies 4th place, being behind only lung cancer (1.8 million), breast (1.7 million), and intestine (1.4 million). In the year 2012, approximately 1,112,000 new global cases of CaP were registered, with about 307,000 deathsOBJECTIVE: To analyze the epidemiological profile of mortality from prostate cancer and the access of patients to health among Brazilian regionsMETHODS: Ecological study based on secondary data from between the years 2000 and 2015. Mortality, hospitalization, and population were collected at the DATASUS. The variables were related to the epidemiological profile of CaP among Brazilian regions, stratified by the number of hospitalizations, of deaths, admission fee, mortality rate, and age group (40 to 79 years). The study looks at a time trend and gains access to health and mortality using regression modelsRESULTS: The northern showed a greater decrease in cases from 40-59 years (β: -1,800; -0.46). Southeast, with a small reduction only between 40 and 44 years old (β: -0.345 and p: 0.665). Northeast, South, and Center-West regions did not express a drop in the hospitalization rate, with the greatest growth between 65 and 69 years old (β: 7,862; 11,346; and p> 0.05). The Midwest had the greatest increase between 55 and 59 years (β: 3,660, p: 0.098), followed by 65 to 69 years (β: 3,491, p: 0.314). Mortality rates indicated a reduction in the Southeast (β: - 0.440) and South (β: -0.361CONCLUSION: This study found an association with various environmental and economic cultures in each Brazilian region, being an important resource for the development of health services and their access to the population


INTRODUÇÃO: Devido às altas taxas de incidência e mortalidade que o câncer apresenta, a Organização Mundial da Saúde (OMS) define-o como um problema de saúde pública e aponta que existem aproximadamente 10 milhões de pessoas afetadas pelo câncer, a estimativa para o ano de 2020 será 16 milhões de doentes. Uma das neoplasias mais frequentes do mundo, o Câncer de Próstata (CaP) (1,1 milhão) ocupa a 4ª colocação, ficando atrás apenas do câncer de pulmão (1,8 milhão), mama (1,7 milhão) e intestino (1,4 milhões). No ano de 2012, foram registrados aproximadamente 1.112.000 novos casos globais de CaP, com cerca de 307.000 óbitosOBJETIVO: Analisar o perfil epidemiológico da mortalidade por câncer de próstata e o acesso de pacientes à saúde entre as regiões brasileirasMÉTODO: Estudo ecológico baseado em dados secundários entre os anos de 2000 e 2015. A mortalidade, hospitalização e população foram coletadas no DATASUS. As variáveis foram relacionadas ao perfil epidemiológico, entre as regiões brasileiras, estratificadas pelo número de internações; de mortes; taxa de admissão; taxa de mortalidade e faixa etária (40 a 79 anos). O estudo analisa uma tendência temporal e obtém acesso à saúde e mortalidade usando modelos de regressãoRESULTADOS: O Norte apresentou uma queda maior nos casos de 40 a 59 anos (β: -1,800; -0,46). Sudeste, com pequena redução apenas entre 40 e 44 anos (β: -0,345 e p: 0,665). As regiões Nordeste, Sul e Centro-Oeste não apresentaram queda na taxa de internação, com maior crescimento entre 65 e 69 anos (β: 7.862; 11.346; e p> 0,05). O Centro-Oeste teve o maior aumento entre 55 e 59 anos (β: 3.660, p: 0,098), seguido de 65 a 69 anos (β: 3.491, p: 0,314). As taxas de mortalidade indicaram redução no Sudeste (β: - 0,440) e Sul (β: -0,361CONCLUSÃO: Este estudo encontrou associação com várias culturas ambientais e econômicas em cada região brasileira, sendo um recurso importante para o desenvolvimento de serviços de saúde e seu acesso à população


Subject(s)
Humans , Male , Female , Prostatic Neoplasms , Health Profile , Mortality , Universal Access to Health Care Services , Hospital Care , Hospitalization , Ecological Studies
6.
J. Hum. Growth Dev. (Impr.) ; 31(2): 302-309, May-Aug. 2021. tab
Article in English | LILACS, INDEXPSI | ID: biblio-1340089

ABSTRACT

INTRODUCTION: In Brazil, access to health care is a constitutional right guaranteed by the Unified Health System that provides, in its guiding principles, universality, and equity of access to health servicesOBJECTIVE: To analyze the factors associated with the quilombola population's access to health servicesMETHODS: Cross-sectional study with 91,085 quilombolas. To measure the absence of access to health, the variables sex, ethnicity, work, disability, age group, illiteracy, place of residence, and average family income were used. The lack of access to health services was due to the identification of health care establishments by quilombola families in the Cadastro Único database. The association between socioeconomic characteristics and the lack of access to health services were assessed using the chi-square test and the measures of magnitude of the association and respective confidence intervals were estimated by Poisson Regression with robust varianceRESULTS: Among the factors associated with access to health services for the quilombola population, it is observed that the group with the highest risk is the elderly quilombolas, who declare themselves indigenous and who reside in the central west region It is noted that in 2004 there was a reduction in the lack of access to health by quilombolas to health services, however, between 2005 and 2015, there is an increase in the lack of access to health by quilombolas, after that period there is an ascendancy of access to health by this populationCONCLUSION: Several factors are associated with access to health by quilombola populations, which, related to the inequalities experienced by this population, directly impact government actions


INTRODUÇÃO: No Brasil, o acesso à saúde é um direito constitucional garantido a partir do Sistema Único de Saúde que prevê, em seus princípios norteadores, a universalidade e a equidade de acesso aos serviços de saúdeOBJETIVO: Analisar os fatores associados ao acesso da população quilombolas aos serviços de saúdeMÉTODO: Estudo transversal com 91.085 quilombolas. Para mensurar a ausência do acesso à saúde utilizou-se as variáveis sexo, etnia, trabalho, deficiência, faixa etária, analfabetismo, local de domicílio e a renda média familiar. A ausência do acesso aos serviços de saúde se deu a partir da identificação dos estabelecimentos de assistência à saúde pelas famílias quilombolas na base de dados do Cadastro Único. A associação entre as características socioeconômicas e a ausência do acesso aos serviços de saúde foram avaliadas pelo teste qui-quadrado e as medidas de magnitude da associação e respectivos intervalos de confiança foram estimados por Regressão de Poisson com variância robustaRESULTADOS: Dentre os fatores associados ao acesso aos serviços de saúde da população quilombolas, observa-se que o grupo com maior risco é os quilombolas idosos, que se autodeclaram indígenas e que residem na região centro oeste. Nota-se que no ano de 2004 houve uma redução na ausência do no acesso à saúde dos quilombolas aos serviços de saúde, entretanto entre 2005 a 2015 iniciou-se um aumento na ausência do acesso à saúde, a partir desse período uma ascendência do acesso à saúde por parte dessa populaçãoCONCLUSÃO: Diversos fatores estão associados ao acesso à saúde pelas populações quilombolas, os quais, relacionado às desigualdades vivenciadas por essa população, impactam diretamente nas ações governamentais


Subject(s)
Humans , Male , Female , Unified Health System , Information Systems , Ethnicity , Cross-Sectional Studies , Vulnerable Populations , Health Services Accessibility
7.
J. Hum. Growth Dev. (Impr.) ; 31(2): 291-301, May-Aug. 2021.
Article in English | LILACS, INDEXPSI | ID: biblio-1340088

ABSTRACT

INTRODUCTION: metabolic syndrome (SM) is a set of metabolic imbalances that are associated with the development of cardiovascular diseases, type 2 diabetes mellitus, in addition to other chronic non-communicable diseases. SM has been gaining prominence in the scientific community mainly due to link with the increase of the obesity epidemic in the worldOBJECTIVE: To analyze the factors associated with metabolic syndrome and its prevalence in a vulnerable population in the Northern Region of BrazilMETHODS: This is a cross-sectional study with artisanal fishers from the state of Tocantins, and data collected between 2016 and 2017 were used. The outcome variable for MS was defined according to the criteria of the International Diabetes Federation. The following variables were assessed: socioeconomic and demographic information, fish consumption, and smoking. For statistical and data analysis, the Shapiro-Wilk test, Poisson regression, Student's t-test, and interquartile regression were evaluatedRESULTS: The general prevalence rate (PR) of MS was 31.9% higher in women than in men. The factors associated with MS were economic class and smoking, and there was an association between socioeconomic class and smoking (p=0.015). The most prevalent component was abdominal obesity with a rate of 62.5% (95% confidence interval [CI]: 54.5, 70.5). The prevalence of MS in terms of sex (PR=2.27, 95% 1.04 CI, 4.92, p=0.037), smoking (PR=2.40, 95% CI, 30, p=0.003) and years of professional experience (>10 PR=2.07, 95% CI 1.06, 4.05, p=0.033) was also assessedCONCLUSION: In the present study, the prevalence of SM was associated with smoking and socioeconomic status, which is considered high when compared to the worldwide prevalence. These findings highlight the importance of looking at public policies so that health services can develop actions that generate greater adherence to good health practices by the population


INTRODUÇÃO: A síndrome metabólica (SM) é um conjunto de desequilíbrios metabólicos que estão associados ao desenvolvimento de doenças cardiovasculares, diabetes mellitus tipo 2 além de outras doenças crônicas não transmissíveis. A SM vem ganhando destaque na comunidade científica principalmente por sua ligação com o aumento da epidemia de obesidade no mundoOBJETIVO: Analisar os fatores associados à síndrome metabólica e sua prevalência em população vulnerável da Região Norte do BrasilMÉTODO: Trata-se de um estudo transversal com pescadores artesanais do estado do Tocantins, e foram utilizados dados coletados entre 2016 e 2017. A variável desfecho para SM foi definida de acordo com os critérios da International Diabetes Federation. As seguintes variáveis foram avaliadas: informações socioeconômicas e demográficas, consumo de peixe e tabagismo. Para análise estatística e de dados, foram avaliados o teste de Shapiro - Wilk, regressão de Poisson, teste t de Student e regressão interquartilRESULTADOS: A taxa geral de prevalência (RP) da SM foi 31,9% maior em mulheres do que em homens. Os fatores associados à SM foram classe econômica e tabagismo e houve associação entre classe socioeconômica e tabagismo (p = 0,015). O componente mais prevalente foi obesidade abdominal com uma taxa de 62,5% (intervalo de confiança de 95% [IC]: 54,5, 70,5). A prevalência de SM em termos de sexo (RP = 2,27, IC 95% 1,04, 4,92, p = 0,037), tabagismo (RP = 2,40, IC 95%, 30, p = 0,003) e anos de experiência profissional (> 10 RP = 2,07, IC 95% 1,06, 4,05, p = 0,033) também foi avaliadoCONCLUSÃO: No presente estudo, a prevalência de SM esteve associada ao tabagismo e ao nível socioeconômico, sendo considerada elevada quando comparada a prevalência mundial. Esses achados assinalam a importância de um olhar das políticas públicas para que os serviços de saúde possam desenvolver ações que geram maior adesão as boas práticas de saúde pela população


Subject(s)
Humans , Male , Female , Cardiovascular Diseases , Cross-Sectional Studies , Metabolic Syndrome , Vulnerable Populations , Life Style , Obesity
8.
Rev. Assoc. Med. Bras. (1992) ; 66(11): 1503-1508, Nov. 2020. tab
Article in English | LILACS, SES-SP | ID: biblio-1143639

ABSTRACT

SUMMARY OBJECTIVE: To characterize the effects of nasal aspiration with Proetz® in peak nasal inspiratory flow (PNIF) in pediatric sinusitis (PS) patients with nasal obstruction. METHODS: This is a non-randomized descriptive-analytical clinical trial with a quantitative approach. The sample comprised 30 children. Initially, the PNIF was measured and the Visual Analogical Scale (VAS) was used for nasal obstruction, followed by the nasal aspiration procedure. The SNOT-22 questionnaire was applied to the legal guardian of each child, and one week later, it was reapplied for the sake of follow-up. RESULTS: 16 (53.3%) patients were females and 14 (46.7%) were males, with an average age of 6.4±1.8 years (between 4 and 10 years of age). Analyses of the VAS for obstruction before the intervention revealed that 10 of the participants (33.3%) presented moderate levels, and 20 of them (66.7%) severe levels. However, after the Proetz® method was applied, all the samples (n=30) had mild levels. The PNIF significantly increased after the technique was used, with an improvement of 23.4% in mean values. There was no significant correlation between the VAS and the PNIF. CONCLUSION: Nasal aspiration with the Proetz® method significantly improved the clinical condition of sinusitis patients with nasal obstruction according to the visual analogical scale, the PNIF, and the SNOT-22 questionnaire. No correlation between the VAS and the PNIF could be found. The study confirms the importance of non-pharmacological interventions in the treatment of sinusitis in children, thus resulting in an improvement in their quality of life.


RESUMO OBJETIVO: Caracterizar os efeitos da aspiração nasal com Proetz® no pico do fluxo inspiratório nasal (Pnif) em pacientes com sinusite pediátrica (SP) com obstrução nasal. MÉTODOS: Trata-se de um ensaio clínico analítico descritivo, não randomizado, com abordagem quantitativa. A amostra foi composta por 30 crianças. Inicialmente, o Pnif foi medido e a escala visual analógica (EVA) foi utilizada para obstrução nasal, seguida do procedimento de aspiração nasal. O questionário Snot-22 foi aplicado ao responsável legal de cada criança e, uma semana depois, foi reaplicado para fins de acompanhamento. RESULTADOS: Dezesseis (53,3%) pacientes eram do sexo feminino e 14 (46,7%) do sexo masculino, com idade média de 6,4±1,8 anos (entre 4 e 10 anos). A análise da EVA para obstrução antes da intervenção revelou que dez dos participantes (33,3%) apresentaram níveis moderados e 20 deles (66,7%), níveis graves. No entanto, após a aplicação do método Proetz®, todas as amostras (n=30) apresentaram níveis leves. O Pnif aumentou significativamente após a utilização da técnica, com uma melhoria de 23,4% nos valores médios. Não houve correlação significativa entre EVA e Pnif. CONCLUSÃO: A aspiração nasal com o método Proetz® melhorou significativamente o quadro clínico de pacientes com sinusite com obstrução nasal, de acordo com a escala visual analógica, o Pnif e o questionário Snot-22. Não foi encontrada correlação entre EVA e Pnif. O estudo confirma a importância de intervenções não farmacológicas no tratamento da sinusite em crianças, resultando em melhoria na sua qualidade de vida.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Sinusitis/therapy , Quality of Life , Nasal Obstruction , Surveys and Questionnaires , Visual Analog Scale
9.
ABCS health sci ; 45(Supl. 3): e020103, 10 June 2020. tab
Article in English | LILACS | ID: biblio-1252368

ABSTRACT

INTRODUCTION: The incidence of cystoid macular edema (CME) after cataract surgery varies substantially and depending on the diagnostic method used. In addition, other factors that influence the incidence of CME are the technique of surgery and the associated comorbidities. OBJECTIVE: The aim of the present study was to evaluate the incidence of EMC after uncomplicated phacoemulsification surgery, using the spectral domain optical coherence tomography (OCT). METHODS: The incidence of subclinical and clinical CME was evaluated in 14 patients who underwent uncomplicated phacoemulsification surgery, using OCT before the surgical procedure and after seven and 28 days after it. The volunteers could not use a prostaglandin analogue or present any retinopathy that compromised visual acuity. RESULTS: The incidence of clinically significant CME was 6.4%, however retinal thickening by OCT was observed in all patients in the fourth postoperative week. Regarding gender and laterality, the percentages were similar. CONCLUSION: In this study, we obtained a low incidence of EMC in patients assisted at this center, corroborating multicenter studies.


Subject(s)
Humans , Male , Female , Postoperative Period , Cataract , Macular Edema/epidemiology , Macular Edema/diagnostic imaging , Phacoemulsification , Tomography, Optical Coherence , Visual Acuity , Eye Health Services
10.
ABCS health sci ; 45(Supl. 3): e020104, 10 June 2020. tab
Article in English | LILACS | ID: biblio-1252373

ABSTRACT

INTRODUCTION: Macula edema consists in one of the most common causes of visual impairment. OBJECTIVE: To evaluate the safety and efficacy of continuous release of 0.7 mg dexamethasone (using implantable device) for treatment of macular edema. METHODS: Cross-sectional observational study of 16 patients treated with 0.7 mg dexamethasone intraocular implant. Visual acuity, intraocular pressure and central macular thickness were recorded at baseline, 1-month and 3-month follow-up. RESULTS: 15 eyes of 13 patients were included. Most eyes (n=9) improve visual acuity from baseline at 1-month follow-up; this improvement persisted through 3-monyh follow-up in six eyes. The central macular thickness decreased in the majority of the subjects at 1-month (n=12) and at 3-month (n=10) follow-up. Three eyes presented with elevated intraocular pressure. CONCLUSION: Dexamethasone implant can both reduce the risk of vision loss and improve anatomical features of macular edema due to several pathologies studied. This implant may be used safely and should be considered a therapeutic option to Brazilian Public Health System.


Subject(s)
Humans , Dexamethasone , Macular Edema/drug therapy , Intravitreal Injections , Visual Acuity , Endothelial Growth Factors , Diabetes Mellitus , Diabetic Retinopathy , Eye Health Services , Intraocular Pressure
11.
ABCS health sci ; 45(Supl. 3): e020107, 10 June 2020. tab, graf
Article in English | LILACS | ID: biblio-1252383

ABSTRACT

INTRODUCTION: Epidemiological studies and about patients' waiting time on queues for corneal transplantation are important, as they allow us to know the assisted population and assist the medical team. OBJECTIVE: To evaluate the epidemiological and demographic profile of patients undergoing corneal transplantation from January 2014 to September 2018 at a teaching hospital in the city of Santo André, as well as their waiting time for the procedure. METHODS: Retrospective descriptive study, performed through analysis of medical records and data from the website of the Government of the State of São Paulo's transplant center. The study was conducted at the External and Corneal Diseases sector of the discipline of Ophthalmology from Centro Universitário FMABC. The following data were evaluated: gender, age, race, origin and waiting time for the patient to have a transplant. RESULTS: A total of 139 corneal transplant patients were recruited for the study, with a mean age of 47.4±23 years. According to gender, just over half of the transplanted were female (50.4%). Regarding to skin color, 45.3% of the patients were white, 44.6% were brown and 10.1% were black. As for their origin, most patients were from the city of Santo André. CONCLUSION: This study enabled the assessment and knowledge of the epidemiological profile and waiting time for corneal transplantation in our patients. This information is important, as it helps us to understand the profile of the assisted population and in the organization and planning of the medical team, contributing to better guidance and care for the patients.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Health Profile , Demography , Waiting Lists , Corneal Transplantation , Hospitals, State , Retrospective Studies
12.
ABCS health sci ; 45(Supl. 3): e020106, 10 June 2020. tab, graf
Article in English | LILACS | ID: biblio-1252378

ABSTRACT

INTRODUCTION: It is known that vision disorders are within the context of public health problems. In childhood, during the neuropsychomotor development phase, visual changes are crucial, since there is a strong correlation between poor school performance and changes in acuity. For these reasons, ophthalmological examination in children, including refraction, is extremely important, aiming at the early diagnosis of diseases and possible refractive errors that may compromise the child's life and development. 1% cyclopentolate hydrochloride eye drops are the most used during ophthalmic clinical evaluation as a cycloplegic and mydriatic agent to assist in refractive examination. OBJECTIVE: The ocular and systemic side effects of 1% cyclopentolate hydrochloride eye drops were studied in patients who underwent static refractive examination in the strabismus sector of the Ophthalmology Discipline of the Centro Universitário FMABC. METHODS: A drop of 1% cyclopentolate is instilled in both eyes of each patient and the possible ocular and systemic signs and symptoms presented were observed after 40 minutes and 24 hours after instillation. RESULTS: We expect to find ocular side effects more evident than systemic symptoms in the two evaluation times (40 minutes and 24 hours after instillation). All symptoms (ocular and systemic) are reversed spontaneously. CONCLUSION: The present study aims to show that the side effects observed by the topical (ocular) use of cyclopentolate eye drops 1% are few and present spontaneous reversal both from an eye point of view, as well as from a systemic point of view.


Subject(s)
Humans , Male , Female , Child , Adolescent , Ophthalmic Solutions/adverse effects , Refraction, Ocular , Child Health , Cyclopentolate/adverse effects , Adolescent Health , Eye Health Services , Prospective Studies , Diagnostic Techniques, Ophthalmological
13.
ABCS health sci ; 45(Supl. 3): e020108, 10 June 2020.
Article in English | LILACS | ID: biblio-1252391

ABSTRACT

Diabetic Macular Edema is a major cause of visual impairment in economically active population, being responsible for a significant impact in quality of life in the affected population, as well as high costs to the health care system. Over decades, some studies have compared treatments using Laser, Anti-VEGF and intravitreous corticosteroids, establishing protocols to reach effectives therapies. Thus, it is essential an entire understanding of available therapies to reach the goal of disease control, in an individual basis and in a collective health care system, as efficient as possible.


Subject(s)
Humans , Macular Edema/therapy , Diabetes Complications , Laser Coagulation , Vascular Endothelial Growth Factors , Tomography, Optical Coherence , Intravitreal Injections
14.
ABCS health sci ; 45: e020027, 02 jun 2020. tab
Article in English | LILACS | ID: biblio-1129782

ABSTRACT

INTRODUCTION: Frailty is a multidimensional syndrome that increases the vulnerability in the elderly, decreasing physiological reserves, intensifying the functional decline, being associated with numerous physical changes, determining greater risks to the elderly's health. OBJECTIVE: To analyze the association between frailty and sociodemographic conditions of the elderly met in primary care facilities in the city of Cajazeiras, northeastern Brazil. METHODS: A cross-sectional study, conducted in July 2015, with 823 elderly people through semi-structured questionnaire containing the proposed frailty criteria by Linda Fried and colleagues, and analyzed using SPSS version 21. The Chi-Square test was used to assess the association between variables, considering p<0.05 as statistically significant. The sociodemographic data were collected using an instrument created by the authors. RESULTS: The prevalence of frailty was 23.8% and is associated with older age groups (70-90 years) and older people who did not attend school (25.5%), and the main criterion of frailty found among the elderly was "slow walk" (71.7%). CONCLUSION: The frailty in elderly from Northeastern Brazil is associated with higher age and illiteracy.


INTRODUÇÃO: A fragilidade é uma síndrome multidimensional que aumenta a vulnerabilidade em idosos, causando diminuição das reservas fisiológicas, aumento do declínio funcional e está associada a inúmeras alterações físicas, determinando maiores riscos à saúde do idoso. OBJETIVO: Analisar a associação entre fragilidade e condições sociodemográficas de idosos atendidos em Unidades Básicas de Saúde da cidade de Cajazeiras, nordeste do Brasil. MÉTODOS: Estudo transversal, realizado em julho de 2015, com 823 idosos, por meio de questionário semiestruturado contendo os critérios de fragilidade propostos por Linda Fried e analisado pelo SPSS versão 21. Utilizou-se o teste qui-quadrado para verificar a associação entre as variáveis, considerando-se estatisticamente significativo p<0,05. Coletaram-se os dados sociodemográficos por meio de instrumento elaborado pelos autores. RESULTADOS: A prevalência de fragilidade foi de 23,8% e está associada a faixa etária mais velha (70-90 anos), idosos que não frequentaram a escola (25,5%), e a principal característica de fragilidade encontrada entre os idosos era "lenta" (71,7%). CONCLUSÃO: A fragilidade em idosos do Nordeste Brasileiro está associada à idade e ao analfabetismo.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Socioeconomic Factors , Aging , Health Centers , Demography , Frail Elderly , Frailty , Cross-Sectional Studies
15.
J. bras. nefrol ; 42(1): 47-52, Jan.-Mar. 2020. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1098337

ABSTRACT

ABSTRACT Background: Renal replacement therapy continues to be related to high hospitalization rates and poor quality of life. All-cause morbidity and mortality in renal replacement therapy in greater than 20% per year, being 44 times greater when diabetes is present, and over 10 times that of the general population. Regardless of treatment, the 5-year survival is 40%, surpassing many types of cancers. Irisin is a hormone that converts white adipose tissue into beige adipose tissue, aggregating positive effects like fat mass control, glucose tolerance, insulin resistance, prevention of muscle loss, and reduction in systemic inflammation. Objectives: To determine the serum levels of troponin I in hemodialysis patients submitted to remote ischemic preconditioning (RIPC) associated with irisin expression. Methods: This was a prospective, randomized, double-blind clinical trial with patients with chronic kidney disease submitted to hemodialysis for a 6-month period. Troponin I, IL-6, urea, TNF-α, and creatinine levels were determined from blood samples. The expressions of irisin, thioredoxin, Nf-kb, GPX4, selenoprotein and GADPH were also evaluated by RT-PCR. Results: Samples from 14 hypertensive patients were analyzed, 9 (64.3%) of whom were type 2 diabetics, aged 44-64 years, and 50% of each sex. The difference between pre- and post-intervention levels of troponin I was not significant. No differences were verified between the RIPC and control groups, except for IL-6, although a significant correlation was observed between irisin and troponin I. Conclusion: Remote ischemic preconditioning did not modify irisin or troponin I expression, independent of the time of collection.


RESUMO Introdução: A terapia de substituição renal continua associada a altas taxas de hospitalização e baixa qualidade de vida. A morbimortalidade por todas as causas na terapia de substituição renal é superior a 20% ao ano, sendo 44 vezes maior quando a diabetes está presente e mais de 10 vezes a da população em geral. Independentemente do tratamento, a sobrevida em 5 anos é de 40%, superando muitos tipos de câncer. A irisina é um hormônio que converte tecido adiposo branco em tecido adiposo bege, agregando efeitos positivos como o controle de massa gorda, tolerância à glicose, resistência à insulina, prevenção de perda muscular e redução da inflamação sistêmica. Objetivos: Determinar os níveis séricos de troponina I em pacientes em hemodiálise submetidos ao pré-condicionamento isquêmico remoto (PCIR) associado à expressão da irisina. Métodos: Estudo clínico prospectivo, randomizado, duplo-cego, com pacientes com doença renal crônica submetidos à hemodiálise por um período de 6 meses. Os níveis de troponina I, IL-6, uréia, TNF-α e creatinina foram determinados a partir de amostras de sangue. As expressões de irisina, tioredoxina, Nf-kb, GPX4, selenoproteína e GADPH foram também avaliadas por RT-PCR. Resultados: Foram analisadas amostras de 14 pacientes hipertensos, 9 (64,3%) dos quais eram diabéticos tipo 2, com idades entre 44 e 64 anos e 50% de cada gênero. A diferença entre os níveis pré e pós-intervenção de troponina I não foi significativa. Não houve diferenças entre os grupos PCIR e controle, exceto pela IL-6, embora tenha sido observada correlação significativa entre irisina e troponina I. Conclusão: O pré-condicionamento isquêmico remoto não modificou a expressão de irisina ou troponina I, independentemente do tempo de coleta.

16.
Rev. bras. anal. clin ; 52(1): 93-98, 20200330. tab, graf
Article in English | LILACS | ID: biblio-1116504

ABSTRACT

Objective: The objective of this study was to evaluate the prevalence of enteroparasitosis in stool samples from residents of São Bernardo do Campo ­ SP, who use the public health service through the Basic Health Unit (UBS), defining the most frequent enteroparasites by age. and district with the highest prevalence. Methods: For this retrospective study, 17,018 fecal examinations were performed from June to December 2017. The data came from the Parasitology Laboratory of the Centro Universitário Saúde ABC ­ FMABC, and the prevalence of enteroparasitosis by age and district was analyzed. The project was approved by the Research Ethics Committee of Universidade Paulista ­ UNIP, under nº 2.715.169. Results: The most common protozoan (33.86%) was Giardia spp., followed by Entamoeba histolytica/dispar, most common in young adults aged 18 to 40 years (9.16%). Enterobius vermicularis had a prevalence of 5.58%, being more frequent in children from 0 to 11 years old. In adults (41-65 years) and elderly (> 65 years), the most common helminth found in the samples was Strongyloides stercoralis (18%). Conclusion: It is concluded that Giardia spp. was the most frequent parasite and frequently observed in children (0-11 years), in the elderly was Strongyloides stercoralis. This study serves as a warning about the need to implement efficient public health, focused mainly on the prevention and control of these and other types of diseases.


Objetivo: Este trabalho teve como objetivo avaliar a prevalência de enteroparasitoses em amostras de fezes de moradores de São Bernardo do Campo ­ SP que utilizam o serviço público de saúde por meio da Unidade Básica de Saúde (UBS), definindo as enteroparasitas mais frequentes, por idade e bairro com maior prevalência. Métodos: Para este estudo retrospectivo, foram realizados 17.018 exames fecais no período de junho a dezembro de 2017. Os dados foram provenientes do Laboratório de Parasitologia do Centro Universitário Saúde ABC ­ FMABC, sendo realizada a análise de prevalência das entero­parasitoses por idade e bairro. O projeto foi aprovado pelo Comitê de Ética em Pesquisa da Universidade Paulista ­ UNIP, sob o nº 2.715.169. Resultados: O protozoário mais frequente (33,86%) foi Giardia spp., seguido por Entamoeba histolytica/dispar, mais frequente em adultos jovens de 18 a 40 anos (9,16%). Enterobius vermicularis apresentou uma prevalência de 5,58%, sendo mais frequente em crianças de 0 a 11 anos de idade. Em adultos (41-65 anos) e idosos (> 65 anos), o helminto mais frequente encontrado nas amostras foi o Strongyloides stercoralis (18%). Conclusão: Concluímos que Giardia spp. foi o parasita mais frequente e frequentemente observado em crianças (0 a 11 anos), em idosos foi o Strongyloides stercoralis. Este estudo serve como um alerta sobre a necessidade de se implementar uma saúde pública eficiente, voltada principalmente à prevenção e controle desses e de outros tipos de doenças.


Subject(s)
Humans , Adolescent , Adult , Middle Aged , Aged , Parasitic Diseases , Public Health , Environment , Indicators (Statistics)
17.
Arq. bras. cardiol ; 114(1): 100-105, Jan. 2020. tab, graf
Article in English | LILACS | ID: biblio-1055084

ABSTRACT

Abstract Background: The emergence of coronary heart disease is increased with menopause, physical inactivity and with dyslipidemia. Physical training is known to promote the improvement of cardiovascular functions. Objective: To investigate the effects of aerobic physical training on the left ventricle in ovariectomized LDL knockout mice. Methods: Thirty animals were divided into 6 groups (n = 5): Sedentary non-ovariectomized control; Sedentary ovariectomized control; Trained ovariectomized control; Sedentary non-ovariectomized LDL-knockout, sedentary ovariectomized LDL-knockout and trained ovariectomized LDL-knockout. We analyzed the average parameters of apparent density of collagen fibers types I and III, and metalloproteinase type 2 and type 9, were considered significant p < 0.05. Results: The results showed that the proposed exercise protocol altered the volume of type I collagen fibers, altered collagen remodeling parameters (MMP-2), and also reduced the 8-hydroxy-2'-deoxyguanosine (8OHdG) oxidative stress parameter. Conclusion: Moderate intensity aerobic training acts on collagen fiber volume, on collagen remodeling with the reduction of oxidative stress in the left ventricles of ovariectomized LDL-knockout mice.


Resumo Fundamento: O surgimento da doença cardíaca coronariana aumenta com a menopausa, inatividade física e dislipidemia. Sabe-se que o treinamento físico promove a melhora das funções cardiovasculares Objectivo: Investigar os efeitos do treinamento físico aeróbico sobre o ventrículo esquerdo em camundongos LDL knockout ovariectomizadas. Métodos: Trinta animais foram divididos em 6 grupos (n = 5): controle sedentário não ovariectomizado, controle sedentário ovariectomizado, controle treinado ovariectomizado, sedentário LDL-knockout não ovariectomizado, sedentário LDL-knockout ovariectomizado e treinado LDL-knockout ovariectomizado. Analisamos os parâmetros médios da densidade de volume de fibras colágenas tipo I e III, e metaloproteinases 2 e 9. Valores de p < 0,05 foram considerados significativos. Resultados: Os resultados mostram que o protocolo de exercício proposto alterou o volume de fibras colágenas do tipo I e os parâmetros de remodelamento do colágeno (MMP-2), e ainda reduziu o parâmetro de estresse oxidativo do 8-hidroxi-2'-deoxiganosina (8-OhdG). Conclusão: O treinamento aeróbico de intensidade moderada age sobre o volume das fibras colágenas e sobre o remodelamento de colágeno, com redução do estresse oxidativo em ventrículos esquerdos de camundongos ovariectomizados LDLr Knockout.


Subject(s)
Animals , Female , Rats , Matrix Metalloproteinase 2/metabolism , Matrix Metalloproteinase 9/metabolism , Collagen Type I/metabolism , Collagen Type III/metabolism , Inflammation/physiopathology , Myocardium/metabolism , Physical Conditioning, Animal/physiology , Immunohistochemistry , Ovariectomy , Mice, Knockout , Oxidative Stress/physiology , Models, Animal
18.
Rev. Assoc. Med. Bras. (1992) ; 66(1): 36-41, Jan. 2020. tab, graf
Article in English | LILACS | ID: biblio-1091909

ABSTRACT

SUMMARY OBJECTIVE Acne vulgaris in female adolescents, when severe or accompanied by other signs of androgenization, may represent a sign of hyperandrogenemia often underdiagnosed, which will have harmful consequences for adult life. The objective of this cross-sectional and retrospective study was to demonstrate the incidence of hormonal changes in the cases of female adolescents with severe or extensive acne, with or without other signs of hyperandrogenism, and propose a hormonal research pattern which should be indicated in order to detect early hyperandrogenemia. METHODS The medical records of 38 female patients aged between 9 and 15 years old with grade II and/or III acne were analyzed. The dehydroepiandrosterone sulfate, dehydroepiandrostenedione, and androstenedione, total testosterone, and dihydrotestosterone sulfate hormones were required prior to initiation of treatment. The hormonal dosages were performed in the serum after at least 3 hours of fasting by means of radioimmunoassay tests. RESULTS Of the 38 patients included, 44.7% presented changes in androgen levels (hyperandrogenemia), and the two most frequently altered hormones were DHEA and androstenedione, with the same incidence (23.6%). CONCLUSIONS The correct and early diagnosis provides an effective and agile approach, including antiandrogen therapy, with the purpose of avoiding the reproductive and metabolic repercussions, besides controlling the inflammatory picture and avoid aesthetic complications.


RESUMO OBJETIVO A acne vulgar em adolescentes do sexo feminino, quando grave ou acompanhada de outros sinais de androgenização, pode representar um sinal de hiperandrogenemia muitas vezes subdiagnosticado, que acarretará consequências danosas para a vida adulta. O objetivo deste estudo transversal e retrospectivo foi demonstrar a incidência das alterações hormonais nos casos de adolescentes do sexo feminino com acne grave ou extensa, acompanhada ou não de outros sinais de hiperandrogenismo e propor um padrão de pesquisa hormonal que deve ser indicado com o intuito de detectar precocemente o quadro de hiperandrogenemia. MÉTODOS Foram analisados os prontuários de 38 pacientes do sexo feminino com idades entre 9 e 15 anos, portadoras de quadro de acne grau II e/ou III. Os hormônios sulfato de dehidroepiandrostenediona, dehidroepiandrostenediona, androstenediona, testosterona total e dehidrotestosterona foram solicitados antes do início do tratamento. As dosagens hormonais foram realizadas no soro após pelo menos 3 horas de jejum por meio de exames de radioimunoensaio. RESULTADOS Das 38 pacientes incluídas, 44,7% apresentaram alterações dos níveis de andrógenos (hiperandrogenemia), sendo que os dois hormônios mais frequentemente alterados foram o DHEA e androstenediona, com a mesma incidência (23,6%). CONCLUSÕES O diagnóstico correto e precoce propicia uma abordagem efetiva e ágil, incluindo a terapia antiandrogênica, com a finalidade de evitar as repercussões reprodutivas e metabólicas, além de controlar o quadro inflamatório e evitar complicações estéticas.


Subject(s)
Humans , Female , Child , Adolescent , Acne Vulgaris/blood , Hyperandrogenism/diagnosis , Androgens/blood , Severity of Illness Index , Hyperandrogenism/blood
19.
Rev. Assoc. Med. Bras. (1992) ; 66(1): 67-73, Jan. 2020. tab, graf
Article in English | LILACS | ID: biblio-1091901

ABSTRACT

SUMMARY OBJECTIVES Individuals living with HIV seem to be more prone to changes in the redistribution of body fat, characterized as lipodystrophy, which may occur in conjunction with metabolic diseases. In the present study, such impacts were assessed in adults with and without HIV and associated with the time of virus diagnosis and treatment with antiretroviral. METHODS A cross-sectional study with 123 adults, in which 87 had HIV and 36 without HIV, of both sexes, in outpatient follow-up at the Specialized Care Service (SAE) in Macaé-RJ. The following were made: 1) Alteration in body fat distribution, measured by anthropometric parameters and self-reported lipodystrophy; 2) Biochemical profile; 3) Association between HIV diagnosis time and antiretroviral treatment. RESULTS 54.47% (n = 67) males, 45.52% (n = 56) females, mean age 37 years. Of these 87 were people living with HIV, 29% (n = 25) had self-reported lipodystrophy, mean time of virus infection, and antiretroviral treatment (5.80 ± 4.56 and 5.14 ± 3.82 years), respectively. Patients with self-reported lipodystrophy had a greater change in body fat distribution between 3-6 years of HIV diagnosis and a negative cholesterol profile. The antiretroviral treatment time influenced total cholesterol and triglycerides, even for patients without self-reported lipodystrophy, with a further nine years under treatment. CONCLUSION In this study, the negative cholesterol profile was mainly related to antiretroviral treatment time, even for patients without self-reported lipodystrophy, and changes in body fat distribution, measured by anthropometry, was especially associated with time for HIV infection in those with lipodystrophy self-reported.


RESUMO OBJETIVOS Indivíduos vivendo com HIV parecem mais propensos às alterações na redistribuição da gordura corporal, caracterizada como lipodistrofia, podendo acontecer em conjunto com as metabólicas. No presente estudo avaliaram-se tais impactos em adultos com e sem HIV e se associou ao tempo de diagnóstico do vírus e tratamento com antirretroviral. MÉTODOS Estudo tipo transversal, com 123 adultos, no qual 87 tinham HIV e 36 sem HIV, de ambos os sexos, em seguimento ambulatorial no Serviço de Atendimento Especializado (SAE) em Macaé - RJ. Foram feitos: 1) Alteração na distribuição da gordura corporal, mensurados por parâmetros antropométricos e lipodistrofia autorreferida; 2) Perfil bioquímico; 3) Associação entre tempo diagnóstico do HIV e tratamento com antirretroviral. RESULTADOS Incluíram-se 54,47% (n=67) do sexo masculino, 45,52% (n=56) do feminino, com média de idade de 37 anos. Destes, 87 eram pessoas vivendo com HIV, 29% (n=25) possuíam lipodistrofia autorreferida; tempo médio de infecção pelo vírus e tratamento antirretroviral (5,80±4,56 e 5,14±3,82 anos), respectivamente. Os pacientes com lipodistrofia autorreferida tiveram maior alteração na distribuição da gordura corporal entre 3-6 anos de diagnóstico do HIV e um perfil colesterolêmico negativo. O tempo de tratamento com antirretroviral influenciou o colesterol total e os triglicerídeos, mesmo para os pacientes sem lipodistrofia autorreferida, com mais de nove anos sob tratamento. CONCLUSÃO Neste estudo, o perfil colesterolêmico negativo se relacionou principalmente ao tempo de tratamento com antirretroviral, mesmo para os pacientes sem lipodistrofia autorreferida e as alterações na distribuição da gordura corporal, mensuradas por antropometria, se associaram especialmente ao tempo de infecção pelo HIV naqueles com lipodistrofia autorreferida.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , HIV Infections/drug therapy , HIV-Associated Lipodystrophy Syndrome/physiopathology , HIV-Associated Lipodystrophy Syndrome/epidemiology , Anti-Retroviral Agents/therapeutic use , Body Fat Distribution , Time Factors , Triglycerides/blood , Brazil/epidemiology , Body Mass Index , HIV Infections/blood , Sex Factors , Adipose Tissue/physiopathology , Cholesterol/blood , Cross-Sectional Studies , Risk Factors , Analysis of Variance , Antiretroviral Therapy, Highly Active , HIV-Associated Lipodystrophy Syndrome/blood , Self Report , Middle Aged
20.
Rev. Soc. Bras. Med. Trop ; 53: e20190507, 2020. tab
Article in English | LILACS | ID: biblio-1092191

ABSTRACT

Abstract INTRODUCTION Intra-domiciliary contacts are a group with the highest risk of developing leprosy. METHODS A cross-sectional study of intra-domiciliary contacts of new leprosy cases was conducted. A descriptive analysis of the variables was performed. RESULTS Among 190 contacts, 63% were invited to visit the health unit, and 54.2% received the BCG vaccine. The prevalence of leprosy among the contacts was 4.7%. CONCLUSIONS The occurrence of leprosy among the contacts was high and similar to that found previously. There were failures in surveillance actions carried out by health units. Never-before treated cases were found.


Subject(s)
Humans , Male , Female , Adult , Young Adult , BCG Vaccine/administration & dosage , Contact Tracing/statistics & numerical data , Leprosy/epidemiology , Socioeconomic Factors , Brazil/epidemiology , Population Surveillance , Prevalence , Cross-Sectional Studies , Leprosy/prevention & control , Middle Aged
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