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1.
Article in Chinese | WPRIM | ID: wpr-247768

ABSTRACT

With human placed in the whole nature, by following the biologic evolution path, the property of channel structure for "imprinting template" in meridian andwas explored with supramolecular chemistry. In the history of biologic evolution, each molecule in "molecule society" gradually developed into various highly-ordered supramolecular bodies based on self-identification, self-assembly, self-organization, self-replicating of"imprinting template", and thereby the original biochemical system was established, and finally evolved into human. In the forming process of supramolecular bodies, the channel structure of"imprinting template" in guest supramolecular bodies would be kept by host supramolecular bodies, and communicate with the outside to exchange materials, energy, information, otherwise life phenomenon could not continue, for which it was the chemical nature of biolo-gical supramolecular bodies for body to develop meridian. Therefore, the human was a gigantic and complicated supramolecules body in biological nature, and possessed the supramolecules "imprinting template" at each stage of evolution, for which the meridians were formed. When meridians converged, acupoints appeared; when acupointsconverged,appeared. With the promotion of the blood from heart, according to"imprinting template", the guest supramolecular bodies and host meridian produced-analysis, which was the-phenomenon of guest in meridian. It presented asimage of physiology and pathology as well as action regularities of medication and acupuncture tolerance, by which current various meridian viewpoints could be explained and propose the hypothesis of meridian supramolecular bodies. The meridian and its phenomenon was decide by its "imprinting template" of supramolecular bodies and self-reaction regularities, which abided through the living nature. This was the substance for meridian biology.

2.
Article in Chinese | WPRIM | ID: wpr-494139

ABSTRACT

Objective To study the pharmacokinetic features of ferulaic acid, senkyunolide A and ligustilide in Buyang Huanwu associated prescriptions (Buyang HuanwuDecoction andNaojianTablets).MethodsHPLC-DAD was applied for simultaneous determination plasma concentration of three ingredients with jugular venous cannula rats after intragastric administration ofBuyang Huanwu associated prescriptions. The pharmacolinetic parameters of each ingredient was calculated by DAS2.0, and then the total quantum statistical moment (TQSM) standard similarity was used to measure the overall pharmacokinetics behaviors.Results There were great differences in the three ingredients after the administration of two prescriptions, while the total quantum statistical parameters were very closely. The TQSM pharmacokinetic parameters of the three components inBuyang HuanwuDecoction andNaojian Tablets showed that AUC, MRT, VRT were 240.6 and 133.0, 3.192 min and 3.259 min, 21.59 min2and 19.75 min2, respectively.The similarity was up to 0.977 8.Conclusion The metabolic processes in vivo ofBuyang Huanwu Decoction andNaojianTablets have similarities. The efficacy of Chinese herbal compounds mostly depends on the multi-components overall contributions.

3.
Article in Chinese | WPRIM | ID: wpr-438294

ABSTRACT

This study was aimed to analyze characteristics of Chinese Materia Medica ( CMM ) preparations in order to identify the long-term development direction of this discipline and suggest key questions and strategies to solve the problems. According to the development track of CMM preparation, traditional Chinese medicine (TCM) basic theories and modern new drug research techniques were combined with the author's experiences on modernization study of TCM. This article discussed key issues of CMM preparation development direction, characteristics and is-sues need to be solved and their countermeasures. The results showed that the development direction for CMM preparation discipline should entirety unify CMM preparation system. The medical resource should be convenient which include animal, plant and mineral products. The single determinacy (effectiveness, stability and controlled) and compatibility (prediction, optimization and lowest toxin) will be applied in the guidance of CMM preparation system. In order to achieve goals mentioned above, key issues need to be solved are efficiency categories for in-gredients, genetical stabilities and one sampling charge, emigration rules of properties among ingredients, the ki-netic and stable rules of ingredient extraction, controlled rules for integral models or for disorder and torrent, e-valuation rules in vivo and in vitro, microscopic and macroscopic qualities, determinacy for single administration and compatibility for combination applications. It was concluded that the CMM preparation is a series of integral unified effective ingredient preparations that behave the determinacy for single administration and compatibility for combination applications.

4.
Acta Pharmaceutica Sinica ; (12): 1453-8, 2013.
Article in Chinese | WPRIM | ID: wpr-445483

ABSTRACT

The paper aims to elucidate and establish a new mathematic model: the total quantum statistical moment standard similarity (TQSMSS) on the base of the original total quantum statistical moment model and to illustrate the application of the model to medical theoretical research. The model was established combined with the statistical moment principle and the normal distribution probability density function properties, then validated and illustrated by the pharmacokinetics of three ingredients in Buyanghuanwu decoction and of three data analytical method for them, and by analysis of chromatographic fingerprint for various extracts with different solubility parameter solvents dissolving the Buyanghanwu-decoction extract. The established model consists of four mainly parameters: (1) total quantum statistical moment similarity as ST, an overlapped area by two normal distribution probability density curves in conversion of the two TQSM parameters; (2) total variability as DT, a confidence limit of standard normal accumulation probability which is equal to the absolute difference value between the two normal accumulation probabilities within integration of their curve nodical; (3) total variable probability as 1-Ss, standard normal distribution probability within interval of D(T); (4) total variable probability (1-beta)alpha and (5) stable confident probability beta(1-alpha): the correct probability to make positive and negative conclusions under confident coefficient alpha. With the model, we had analyzed the TQSMS similarities of pharmacokinetics of three ingredients in Buyanghuanwu decoction and of three data analytical methods for them were at range of 0.3852-0.9875 that illuminated different pharmacokinetic behaviors of each other; and the TQSMS similarities (ST) of chromatographic fingerprint for various extracts with different solubility parameter solvents dissolving Buyanghuanwu-decoction-extract were at range of 0.6842-0.999 2 that showed different constituents with various solvent extracts. The TQSMSS can characterize the sample similarity, by which we can quantitate the correct probability with the test of power under to make positive and negative conclusions no matter the samples come from same population under confident coefficient a or not, by which we can realize an analysis at both macroscopic and microcosmic levels, as an important similar analytical method for medical theoretical research.

5.
Article in Chinese | WPRIM | ID: wpr-274358

ABSTRACT

<p><b>OBJECTIVE</b>To explore the once sampling quantitation of Houttuynia cordata through its DNA polymorphic bands that carried information entropy, from other form that the expression of traditional Chinese medicine polymorphism, genetic polymorphism, of traditional Chinese medicine.</p><p><b>METHOD</b>The technique of inter simple sequence repeat (ISSR) was applied to analyze genetic polymorphism of H. cordata samples from the same GAP producing area, the DNA genetic bands were transformed its into the information entropy, and the minimum once sampling quantitation with the mathematical mode was measured.</p><p><b>RESULT</b>One hundred and thirty-four DNA bands were obtained by using 9 screened ISSR primers to amplify from 46 strains DNA samples of H. cordata from the same GAP, the information entropy was H=0.365 6-0.978 6, and RSD was 14.75%. The once sampling quantitation was W=11.22 kg (863 strains).</p><p><b>CONCLUSION</b>The "once minimum sampling quantitation" were calculated from the angle of the genetic polymorphism of H. cordata, and a great differences between this volume and the amount from the angle of fingerprint were found.</p>


Subject(s)
Amplified Fragment Length Polymorphism Analysis , DNA, Plant , Genetic Variation , Houttuynia , Genetics , Microsatellite Repeats , Genetics
6.
Article in Chinese | WPRIM | ID: wpr-289413

ABSTRACT

<p><b>OBJECTIVE</b>To study on the differences between chromatopharmacokinetics (pharmacokinetics with fingerprint chromatography) and chromatopharmacodynamics (pharmacodynamics with fingerprint chromatography) of Chinese materia medica formulae to answer the question whether the pharmacokinetic parameters of multiple composites can be utilized to guide the medication of multiple composites.</p><p><b>METHOD</b>On the base of established four chromatopharmacology (pharmacology with chromatographic fingerprint), the pharmacokinetics, and pharmacodynamics were analyzed comparably on their mathematical model and parameter definition.</p><p><b>RESULT</b>On the basis of quantitative pharmacology, the function expressions and total statistical parameters, such as total zero moment, total first moment, total second moment of the pharmacokinetics, and pharmacodynamics were analyzed to the common expressions and elucidated results for single and multiple components in Chinese materia medica formulae. Total quantitative pharmacokinetic, i.e., chromatopharmacokinetic parameter were decided by each component pharmacokinetic parameters, whereas the total quantitative pharmacodynamic, i.e., chromatopharmacodynamic parameter were decided by both of pharmacokinetic and pharmacodynamic parameters of each components. The pharmacokinetic parameters were corresponded to pharmacodynamic parameters with an existing stable effective coefficient when the constitutive ratio of each composite was a constant.</p><p><b>CONCLUSION</b>The effects of Chinese materia medica were all controlled by pharmacokinetic and pharmacodynamic coefficient. It is a special case that the pharmacokinetic parameter could independently guide the clinical medication for single component whereas the chromatopharmacokinetic parameters are not applied to the multiple drug combination system, and not be used to solve problems of chromatopharmacokinetic of Chinese materia medica formulae.</p>


Subject(s)
Chromatography , Drugs, Chinese Herbal , Chemistry , Pharmacokinetics , Materia Medica , Chemistry
7.
Article in Chinese | WPRIM | ID: wpr-293165

ABSTRACT

<p><b>OBJECTIVE</b>To eluciate and establish a new population pharmacokinetic mathematical models and parameter calculation for the multiple components in the Chinese Matria Medica Formula (CMMF) through analyses of population pharmacokinetic parameter calculation for single compounds.</p><p><b>METHOD</b>The model was been set up by statistic moment principle to form a new population pharmacokinetics for the mutiple components in CMMF according to the single compound population pharmacokinetic parameter calculation principle.</p><p><b>RESULT</b>It have been established the mathematical model for the population pharmacokinetic model for CMMF that consisted of a series of parameters: 1) total quantum zero moment as AUC(T), 2) first moment as MRT(T), mean residence time of metabolism, 3) second moment as VRT(T), variance of mean residence time of metabolism, 4) total body clearance CL(T), 5) total apparent volum V(T), 6) 95% of total ingredient metabolic time interval PI(T)(0.95), 7) 95% of total ingredient accumulation metabolic time interval Pa(T)(0.95) etc that were correlated with single population pharmacokinetic parameters.</p><p><b>CONCLUSION</b>The population pharmacokinetic model and parameter calculation for CMMF can be established on the bases of single compound population pharmacokinetics by way of total quantum statistic moment principle to be expansived taylor expression at point of population parameter typical values to divide population pharmacokinetic total quantum statistical moment parameters into the four term of typical value, fixed effect, biologic variation and experiment error.</p>


Subject(s)
Humans , Medicine, Chinese Traditional , Models, Biological , Pharmacokinetics
8.
Article in Chinese | WPRIM | ID: wpr-251251

ABSTRACT

<p><b>OBJECTIVE</b>To establish and experimental verification the mathematical model of the balance groups that is the steady-state of traditional Chinese medicine in extraction.</p><p><b>METHOD</b>Using the entropy and genetic principles of statistics, and taking the coefficient of variation of GC fingerprint which is the naphtha of the Houttuynia cordata between strains in the same GAP place as a pivot to establish and verify the mathematical model was established of the balance groups that is the steady-state of traditional Chinese medicine in extraction.</p><p><b>RESULT</b>A mathematical model that is suitable for the balance groups of the steady-state of traditional Chinese medicine and preparation in extraction, and the balance groups which is 29 683 strains (approximately 118.7 kg) were gained with the same origin of H. cordata as the model drug.</p><p><b>CONCLUSION</b>Under the GAP of quality control model, controlling the stability of the quality through further using the Hardy-Weinberg balance groups of the H. cordata between strains, the new theory and experiment foundation is established for the steady-state of traditional Chinese medicine in extraction and quality control.</p>


Subject(s)
Chemical Fractionation , Methods , Chromatography, Gas , Drugs, Chinese Herbal , Reference Standards , Houttuynia , Chemistry , Genetics , Models, Statistical , Quality Control
9.
Article in Chinese | WPRIM | ID: wpr-251188

ABSTRACT

<p><b>OBJECTIVE</b>To establish the unitive multicomponent quality system bridged macrostate mathematic model parameters of material quality and microstate component concentration for Chinese materia medica (CMM).</p><p><b>METHOD</b>According to law of biologic laws of thermodynamics, the state functions of macrostate qulity of the CMM were established. The validation test was carried out as modeling drug as alcohol extract of Radix Rhozome (AERR), their enthalpy of combustion was determined, and entropy and the capability of information by chromatographic fingerprint were assayed, and then the biologic apparent macrostate parameters were calculated.</p><p><b>RESULT</b>The biologic macrostate mathematic models, for the CMM quality controll, were established as parameters as the apparent equilibrium constant, biologic enthalpy, Gibbs free energy and biologic entropy etc. The total molarity for the 10 batchs of AERR were 0.153 4 mmol x g(-1) with 28.26% of RSD, with the average of apparent equilibrium constants, biologic enthalpy, Gibbs free energy and biologic entropy were 0.039 65, 8 005 J x mol(-1), -2.408 x 10(7) J x mol(-1) and - 8.078 x 10(4) J x K(-1) with RSD as 6.020%, 1.860%, 42.32% and 42.31%, respectively.</p><p><b>CONCLUSION</b>The macrostate quality models for CMM can represent their intrinsic quality for multicomponent dynamic system such as the CMM, to manifest out as if the forest away from or tree near from to see it.</p>


Subject(s)
Drugs, Chinese Herbal , Materia Medica , Models, Theoretical , Quality Control , Thermodynamics
10.
Article in Chinese | WPRIM | ID: wpr-283254

ABSTRACT

<p><b>OBJECTIVE</b>To study on the differences of metabolites in the blood of rats after injection or oral administration of volatile oil in Houttuyniae Herba and of 2-undecanone in order to validate hypothesis of network compatability and to establish the theoretical foundation of elucidating metabolic mechanism for multiple constituents in Chinese Material.</p><p><b>METHOD</b>A gas chromatography-mass spectrometry method was employed for qualitative determination of the metabolites in blood of rats by injection or oral administration of volatile oil in Houttuyniae Herba and of 2-undecanone, which were compared with the differences between binary two drugs as well as two administration.</p><p><b>RESULT</b>There were 45 kinds of ingredients in volatile oil for original materials for Houttuyniae Herba, and 53, 69 kinds of metabolites were detected in blood of rats for oral administration of volatile oil in Houttuyniae Herba, and 2-undecanone, respectively, whereas 52, 42 kinds of metabolites were detected for injection administration. Although there were various constitutes, i. e. single versus multiple ingredients, administrated by various ways, i. e. oral versus injection, the metabolites were so similar with each manners, in which alpha-pinene and beta-myrcene occurred in two constitute forms and two administrations, while there were 18, 13 kinds of ingredients for oral or injection administration of volatile oil in Houttuyniae Herba, i. e. 34%, 25% of total ingredients, respectively, and 17, 15 kinds of ingredients, i. e. 24.6%, 35.7% for that of, 2-undecanone, respectively, on average of 29.8% that suggested one of third as co-metabolites.</p><p><b>CONCLUSION</b>There are network compatibility existed in metabolism of the houttuynia volatile oil in rats, and similar metabolic pathways in accordance with original plant, among their ingredients no matter alone or multiple constitute forms and oral or injection administration.</p>


Subject(s)
Administration, Oral , Animals , Gas Chromatography-Mass Spectrometry , Herb-Drug Interactions , Houttuynia , Chemistry , Injections, Intravenous , Ketones , Pharmacokinetics , Oils, Volatile , Pharmacokinetics , Plants, Medicinal , Chemistry , Rats
11.
Article in Chinese | WPRIM | ID: wpr-274391

ABSTRACT

<p><b>OBJECTIVE</b>To study the differences of HPLC fingerprints with the total quantum statistical moment for the Buyang Huanwu decoction (BYHWD) processed by various ways, and to verify the additive properties of total quantum statistical moment.</p><p><b>METHOD</b>The extracts of BYHWD were obtained by water extraction and alcohol precipitation firstly, and then were dissolved with five solvents of different solubility parameter from 11.4 Cal(1/2) x cm(-3/2) to 23.40 Cal(1/2) x cm(-3/2) respectively. Their chromatographic fingerprints were determined by HPLC, finally the total quantum statistical moment parameters and its superposition properties were manual calculated and analyzed by their expressions.</p><p><b>RESULT</b>As a contrast as the whole prescription, the similarities of the various processed samples with butanol (11.4 Cal(1/2) x cm(-3/2)), methanol (13.5 Cal(1/2) x cm(-3/2)), 68% methanol (16. 67 Cal(1/2) x cm(-3/2)), 34% methanol (20.03 Cal(1/2) x cm(-3/2)) and distilled water (23.40 Cal(1/2) x cm(-3/2)) were 0. 074, 0. 973, 0. 934, 0. 991, 0. 993, respectively and while the RSD of these total quantum zero moment, center moment and variance of each chromatographic fingerprints for them were 63.04%, 16.22%, 69.38%, which showed significant difference in these chromatographic fingerprints. The total quantum statistical moment parameters of the superimposed chromatographic fingerprint with each sole samples were 3.203 x 10(5) mAu x s, 29.85 min, 389.97 min2, whereas the whole prescription's were 6.548 x 10(4) mAu x s, 29.44 min, 389.00 min2, that suggested that the absolute difference percentages between the superimposed and the whole were 2.209%, 1.389%, 0.2484%, respectively.</p><p><b>CONCLUSION</b>The total quantum statistical moment of the chromatographic fingerprints is of characteristics with additive properties, it can be used in static and dynamic quality controlled analyses in the Chinese medicine multiple component systems.</p>


Subject(s)
Biometry , Methods , Chromatography , Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Chemistry , Solubility
12.
Article in Chinese | WPRIM | ID: wpr-281675

ABSTRACT

<p><b>OBJECTIVE</b>To establish the theories and methods to determine apparent solubility paraneters of multiple components for the Chinese materia medica (CMM) with HPLC fingerprint.</p><p><b>METHOD</b>The mathematical functional expresses to determine the apparent solubility parameters for multiple constituents were established according to total quantum geometrical average retention time (TQGART) for HPLC fingerprint that characterized the entirety tendencies for all-over chromatographic peaks, validated by the aloe-emodin's solubility parameters which had been determined. The HPLC for the aloe-emodin's solubility parameters were carried out with an Alltech Apollo C18 as column, Acetone: Water as mobile phase, gradient elution,flow rate as 1.0 mL x min(-1), the detection wave-length as 430 nm and the temperature as 30 degrees C.</p><p><b>RESULT</b>The mathematical functional model between the TQGART of HPLC chromatographic fingerprint and the total quantum apparent solubility parameters was established and used to determine the aloe-emodin's mixture solubility parameter as 36.12 J(1/2) x cm(-3/2), nearly equal to 35.57, 36.07 J(1/2) x cm(-3/2) calculated by ration of peak area ratios and molecular fraction, respectively.</p><p><b>CONCLUSION</b>The TQGART of HPLC fingerprint can be used to determine simultaneously the apparent or single intrinsic solubility parameters for total quantum or intrinsic solubility parameters for single in multiple constitute systems, by which theoretical and technologic platform to study the compatibility rule and dosage form reform of the single CMM will be established.</p>


Subject(s)
Anthraquinones , Chemistry , Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Chemistry , Models, Theoretical , Solubility
13.
Article in Chinese | WPRIM | ID: wpr-344565

ABSTRACT

<p><b>OBJECTIVE</b>To study the solubility peak and dielectric requirement of the Buyang Huanwu docoction materials, and provide theoretical and experimental foundation for selecting extraction solvent for extracting traditional Chinese drugs (TCD).</p><p><b>METHOD</b>11 types of solvents were employed as single or complex solvent systems, whose solubility parameter and dielectric constant were from 14.11 to 47.86, dielectric requirement from 1 to 80 respectively, to lixiviate Buyang Huanwu decoction (5 g per samples) in nearly saturate volume as V0 for materials at 25 degrees C. The apparent solubilities of extracts were determined and calculated out according to the section of determination of extract in the appendix of 'Chinese Pharmacopoeia'.</p><p><b>RESULT</b>The saturate solvent V0 for materials powder were 0.21, 0.31, 0.49, 0.36, 0.77, 0.93, 0.86, 0.92, 1.08, 1.00, 1.14 mL x g(-1), respectively. The apparent solubility of Buyang Huanwu docoction for each solvent system were 114.0, 101.3, 73.40, 109.4, 210.7, 295.0, 501.4, 437.0, 355.6, 423.1, 210.6 g x mL(-1), respectively, among which the max apparent solubility, illustrated as solubility peak, was carried out by methanol-water (68: 32) with 47.5 corresponding to the Buyang Huanwu docoction dielectric requirement.</p><p><b>CONCLUSION</b>The apparent solubilities of (TCD) and their formula are controlled by dielectric constant of extraction solvent, and are in accordance with stable dielectric requirement.</p>


Subject(s)
Drugs, Chinese Herbal , Chemistry , Solubility , Solvents , Chemistry
14.
Article in Chinese | WPRIM | ID: wpr-344534

ABSTRACT

<p><b>OBJECTIVE</b>To study the release mechanism of Huperzine-A swelling sustained-release tablets (HA-ST) and the factors influencing the release rate.</p><p><b>METHOD</b>The HA-ST were prepared by using Polyoxyethylene (PEO) as the matrix material, polyvinyl alcohol (PVA) as the expandable reagent and microcrystalline cellulose (MCC) as the filling reagent. The effect of the amount of PEO, PVA and MCC on the drug release from the tablets was evaluated using the release index n value of the Ritger-Peppas equation.</p><p><b>RESULT</b>The addition of PEO and PVA speeded up the rate of drug release from the tablets, while MCC did not affect the release rate. The release profiles of HA-ST conformed to the Higuchi model and the release mechanism was non-Fick release that coupled diffusion and erosion.</p><p><b>CONCLUSION</b>The release of HA-ST is influenced by the amount of PEO and PVA but not the MCC. The release process can be depicted by the Ritger-Peppas equation and release mechanism was is non-Fick release.</p>


Subject(s)
Alkaloids , Cellulose , Chemistry , Delayed-Action Preparations , Chemistry , Pharmacokinetics , Diffusion , Models, Biological , Polyethylene Glycols , Chemistry , Sesquiterpenes , Chemistry , Pharmacokinetics , Tablets , Chemistry , Pharmacokinetics
15.
Article in Chinese | WPRIM | ID: wpr-538615

ABSTRACT

AIM:To establish a network pharmacoki- netic model for studying multiple drug components and analyzing their parameters.METHODS:A model has been set up based on the compartment and linear kinetic theories,and the solutions have been obtained by Laplace transform method.The relations between the whole comp- artment model and network model for multiple component have been comparatively studied and their kinetic parame- ters have also been estimated and analyzed.RESULTS: The multiple component network pharmacokinetics follow a first order linear mammillary model.C_i is a polynomial of power index number e,which is similar to the whole compartment model.Various parameters(transit constant) were calculated by the expression of matrix consisting of?_i and the compartment parameters.Its kinetic parameters can be obtained on the basis of the whole compartment model.CONCLUSION:The multiple component net- work pharmacokinetic parameters can be obtained and an- alyzed similarly as the whole compartment model.

16.
Article in Chinese | WPRIM | ID: wpr-682505

ABSTRACT

AIM: To establish a new kinetic model of hydrating swelling and to make experiments of Radix et Rhizoma Rhei (Rhubarb) designed to validate this model. METHODS: The model was set up according to kinetics, residul water analysis was adopted to measure Rhubarb's sakage, and then obtained the fittin curve and kinetic parameters, its goodness of fit was evaluated by analysis of variance. RESULTS: Hydrating swelling model of the vegetable herb had a form of multivariate first order linear differential equation. Rhubarb comformed to three compartment model with ? = 0.3241min -1 , ? = 0.0185min -1 , ?=5.659?10 -3 min -1 , V ∞ T =1.726mL?g -1 , V ∞ 1 =1.008mL?g -1 , V ∞ 2 =0.2814mL?g -1 V ∞ 3 =0.4366mL?g -1 ,K= 0.2186min -1 ,K 12 =0.02426min -1 ,K 21 =0.07422min -1 ,K 13 =6.402?10 -3 min -3 ,K 31 =0.02481min -1 . CONCLUSION: The kinetic model of hydrating swelling has been in accordance with quantitative changes with multivariate first order linear mammary.

17.
Article in Chinese | WPRIM | ID: wpr-579125

ABSTRACT

AIM: To study and evaluate release rules of Zuojin Sustained-Release Tablet(ZJSRT). METHODS: The total quantum statistical moment similarity(TQSMS)was used to evaluate similarity of the chromatographic fingerprints of ZJSRT in vitro dissolution; RESULTS: Compared with the chromatographic fingerprint of the complete dissolution sample,the averages of area under curve of total quantum,mean chromatographic retention time of total quantum and variance of mean chromatographic retention time of total quantum of the ZJSRT's release rules in vitro,from 1 to 12 h,were 2.620?10~8 ?v?sec,74.599 min and 252.481 min~2 respectively,meanwhile their RSD were 62.445%、1.268% and 2.777% coincidently,the similarities range from 0.947 to(0.991,)as average of 0.977 and RSD of 1.491%. CONCLUSION: It is suggested that the TQSMS can evaluate release rules of multicompon and control its quality.

18.
Article in Chinese | WPRIM | ID: wpr-573957

ABSTRACT

AIM: To study the volatile oil of GanluXiaodu Granules GLXD (Talcum, Herba Artemisiae Scopariae, Radix Scutellariae etc.) and establish it's fingerprint. METHODS: By capillary gas chromatography. RESULTS: The fingerprints of volatile oil in Ganlu Xiaodu Granules were composed of 56 peaks, among which there were 17 characteristic peaks, having 86.97% of total area of the whole fingerprints peaks. The average RSD of retention time of characteristic peaks was 0.33%, that of peak-area was 2.76%. CONCLUSION: The fingerprints of volatile in Ganlu Xiaodu Granules can be used to control the quality.

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