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1.
Article in English | WPRIM | ID: wpr-926044

ABSTRACT

Objective@#: The surgical management of trigeminal neuralgia (TN) caused by petrous apex meningioma (PAM) is still a challenge because of the lesion’s deep location and the surrounding complex structures. The authors describe the intradural anterior transpetrosal approach (ATPA) and its effect on the treatment of TN secondary to PAM. @*Methods@#: A retrospective analysis of 15 patients with TN secondary to PAM who underwent surgery via the intradural ATPA was conducted. The key techniques, which included drilling off the petrosal apex (PA) and opening the upper wall of Meckel’s cave (MC), are described in detail. @*Results@#: Total removal of the tumor and complete pain relief (Barrow Neurological Institute I) were achieved in all 15 patients without significant morbidity. Five patients developed new facial numbness postoperatively, which disappeared within three months after surgery. The postoperative magnetic resonance imaging showed temporal lobe swelling in three patients, but no clinical symptoms. One patient had cerebrospinal fluid leakage and was managed with bed rest and temporary lumbar drainage. One patient had an intracranial infection and was treated with antibiotics. By the last follow up, no patients had pain relapse or/and tumor recurrence. It is worth noting that the vascular compression at the root of the trigeminal nerve was found in one patient during the operation. @*Conclusion@#: Our experience suggests that drilling off the PA and opening the upper wall of the MC are key elements for a good outcome of the treatment of TN secondary to PAM. The intradural ATPA has the advantages for both tumor resection and pain relief.

2.
Article in Chinese | WPRIM | ID: wpr-862584

ABSTRACT

Abstract@#The visual health of children and adolescents in China has become a major issue that is relevant to the nation s present and its future. This article analyzed the value of map reading and searching for specific features during orienteering projects for myopia prevention and control. The findings suggest that orienteering exercises show good regulatory effects on eye muscles, effectively improve concentration, and help to stimulate mental activity and visual system. Targeted exercises, including scanning maps for specific features, is beneficial for myopia prevention and control. It is proposed that, by changing the teaching style of cross-country orienteering, teaching space, and teaching scene, exercises can be tailored to treat and relieve eye strain, as well as to prevent and control myopia, which is essential to promote the visual health of children and adolescents.

3.
Article in Chinese | WPRIM | ID: wpr-878940

ABSTRACT

Based on the clinical characteristics of chronic atrophic gastritis in traditional Chinese and Western medicine, the domestic and foreign relevant literature reports and animal models of chronic atrophic as well as the clinical diagnostic indicators of traditional Chinese and western medicine, chronic atrophic gastritis evaluation standard was summarized to evaluate and analyze the coincidence degree of clinical symptoms of the existing chronic atrophic gastritis animal models. The statistical results found that modeling methods with a higher coincidence degree with the existing chronic atrophic gastritis animal models are disease and syndrome combination mode-ling, surgical modeling, multifactor comprehensive modeling and MNNG modeling. Although the animal models were reproduced by such methods as etiology, pathogenesis and disease and syndrome combination similar to those of human beings, there is still a big gap with the natural disease state. Further in-depth studies and improvement shall be made in clinical practice in the hope to provide refe-rence for clinical practice and experimental studies of chronic atrophic gastritis.


Subject(s)
Animals , China , Drugs, Chinese Herbal , Gastritis, Atrophic , Humans , Medicine , Medicine, Chinese Traditional , Models, Animal
4.
Article in Chinese | WPRIM | ID: wpr-878939

ABSTRACT

The evaluation standard of LEAD animal model was established according to the understanding of the etiology and pathogenesis of diabetic lower extremity vascular disease based on Chinese and Western medicine. The consistency between the existing LEAD animal model and the clinical characteristics of traditional Chinese and Western medicine was analyzed and evaluated. The advantages and disadvantages of the existing model were compared,the application scope of different models was considered,and the possible improvement methods of the existing model were proposed,so as to provide impetus for the improvement of LEAD animal model.We should reflect more characteristics of traditional Chinese medicine syndromes in the process of model improvement and development,making the LEAD animal model to get closer to clinical features of traditional Chinese and Western medicine.


Subject(s)
Animals , China , Diabetes Mellitus/drug therapy , Drugs, Chinese Herbal , Lower Extremity , Medicine , Medicine, Chinese Traditional
5.
Article in Chinese | WPRIM | ID: wpr-906311

ABSTRACT

Objective:To explore the macroscopic medication rule of Chinese medicine for the treatment of primary liver cancer and provide references for clinical medication. Method:The databases of CNKI,VIP, and Wanfang Data were searched for research articles published from September 1959 to June 2019 with the terms of "Chinese medicine" and "liver cancer". A database was established based on the collected Chinese medicinal prescriptions for the treatment of primary liver cancer. The frequency,clustering, and association rules were analyzed by Excel, etc. Result:In this study,106 effective articles were included,and after the modified prescriptions were removed, 92 effective prescriptions were screened out,involving 281 Chinese herbal medicines used for 1 181 times in total. The top 5 high-frequency drugs were Poria (deficiency-tonifying),Astragali Radix (heat-clearing),Bupleuri Radix (blood-activating and stasis-resolving),Paeoniae Radix Alba (urination-promoting and dampness-draining), and Codonopsis Radix (Qi-regulating). The analysis of drug flavor with a frequency higher than 10 showed that most of the drugs were sweet,bitter, and pungent in flavor,cold,warm, and plain in nature,and acted on spleen and liver meridians. Four combinations and 10 herbal pairs were obtained by the cluster analysis of high-frequency drugs and association analysis, respectively. The high-frequency drugs and potential herbal pairs were classified targeting the specific clinical syndromes in different stages of liver cancer. Conclusion:Replenishing Qi, invigorating spleen,clearing heat, removing toxin,activating blood, and resolving stasis were the basic principles for the treatment of primary liver cancer. The combination of those drugs was the main therapeutic strategy. In addition,the resulting 10 potential herbal pairs from high-frequency drugs and cluster analysis could inspire the clinical treatment of primary liver cancer in different clinical stages with various clinical syndromes, which was of reference value for the clinical medication.

6.
Article in English | WPRIM | ID: wpr-921870

ABSTRACT

Objective To develope a deep learning algorithm for pathological classification of chronic gastritis and assess its performance using whole-slide images (WSIs). Methods We retrospectively collected 1,250 gastric biopsy specimens (1,128 gastritis, 122 normal mucosa) from PLA General Hospital. The deep learning algorithm based on DeepLab v3 (ResNet-50) architecture was trained and validated using 1,008 WSIs and 100 WSIs, respectively. The diagnostic performance of the algorithm was tested on an independent test set of 142 WSIs, with the pathologists' consensus diagnosis as the gold standard. Results The receiver operating characteristic (ROC) curves were generated for chronic superficial gastritis (CSuG), chronic active gastritis (CAcG), and chronic atrophic gastritis (CAtG) in the test set, respectively.The areas under the ROC curves (AUCs) of the algorithm for CSuG, CAcG, and CAtG were 0.882, 0.905 and 0.910, respectively. The sensitivity and specificity of the deep learning algorithm for the classification of CSuG, CAcG, and CAtG were 0.790 and 1.000 (accuracy 0.880), 0.985 and 0.829 (accuracy 0.901), 0.952 and 0.992 (accuracy 0.986), respectively. The overall predicted accuracy for three different types of gastritis was 0.867. By flagging the suspicious regions identified by the algorithm in WSI, a more transparent and interpretable diagnosis can be generated. Conclusion The deep learning algorithm achieved high accuracy for chronic gastritis classification using WSIs. By pre-highlighting the different gastritis regions, it might be used as an auxiliary diagnostic tool to improve the work efficiency of pathologists.


Subject(s)
Algorithms , Deep Learning , Gastritis/diagnosis , Humans , ROC Curve , Retrospective Studies
7.
Chinese Medical Journal ; (24): 1039-1043, 2020.
Article in English | WPRIM | ID: wpr-827703

ABSTRACT

BACKGROUND@#A patient's infectivity is determined by the presence of the virus in different body fluids, secretions, and excreta. The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease (COVID-19) remain unclear. This study analyzed the clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19, providing further evidence to improve the management of patients during convalescence.@*METHODS@#The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20, 2020 to February 10, 2020 were collected retrospectively. The reverse transcription polymerase chain reaction (RT-PCR) results for patients' oropharyngeal swab, stool, urine, and serum samples were collected and analyzed. Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive (minimum 24 h sampling interval) negative RT-PCR results for viral RNA from oropharyngeal swabs. The effects of cluster of differentiation 4 (CD4)+ T lymphocytes, inflammatory indicators, and glucocorticoid treatment on viral nucleic acid clearance were analyzed.@*RESULTS@#In the 292 confirmed cases, 66 patients recovered after treatment and were included in our study. In total, 28 (42.4%) women and 38 men (57.6%) with a median age of 44.0 (34.0-62.0) years were analyzed. After in-hospital treatment, patients' inflammatory indicators decreased with improved clinical condition. The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5 (6.0-11.0) days. By February 10, 2020, 11 convalescent patients (16.7%) still tested positive for viral RNA from stool specimens and the other 55 patients' stool specimens were negative for 2019-nCoV following a median duration of 11.0 (9.0-16.0) days after symptom onset. Among these 55 patients, 43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs, with a median delay of 2.0 (1.0-4.0) days. Results for only four (6.9%) urine samples were positive for viral nucleic acid out of 58 cases; viral RNA was still present in three patients' urine specimens after throat swabs were negative. Using a multiple linear regression model (F = 2.669, P = 0.044, and adjusted R = 0.122), the analysis showed that the CD4+ T lymphocyte count may help predict the duration of viral RNA detection in patients' stools (t = -2.699, P = 0.010). The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (15 days vs. 8.0 days, respectively; t = 2.550, P = 0.013) and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (20 days vs. 11 days, respectively; t = 4.631, P  0.05).@*CONCLUSIONS@#In brief, as the clearance of viral RNA in patients' stools was delayed compared to that in oropharyngeal swabs, it is important to identify viral RNA in feces during convalescence. Because of the delayed clearance of viral RNA in the glucocorticoid treatment group, glucocorticoids are not recommended in the treatment of COVID-19, especially for mild disease. The duration of RNA detection may relate to host cell immunity.


Subject(s)
Adult , Aged , Betacoronavirus , Genetics , Clinical Laboratory Techniques , Coronavirus Infections , Diagnosis , Genetics , Rehabilitation , Female , Humans , Male , Middle Aged , Pandemics , Pneumonia, Viral , Genetics , Rehabilitation , RNA, Viral , Genetics , Real-Time Polymerase Chain Reaction , Retrospective Studies
8.
Chinese Medical Journal ; (24): E007-E007, 2020.
Article in English | WPRIM | ID: wpr-811525

ABSTRACT

Background@#A patient’s infectivity is determined by the presence of the virus in different body fluids, secretions, and excreta. The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease (COVID-19) remain unclear. This study analyzed the clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19, providing further evidence to improve the management of patients during convalescence.@*Methods@#The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20, 2020 to February 10, 2020 were collected retrospectively. The reverse transcription polymerase chain reaction (RT-PCR) results for patients’ oropharyngeal swab, stool, urine, and serum samples were collected and analyzed. Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive (minimum 24 h sampling interval) negative RT-PCR results for viral RNA from oropharyngeal swabs. The effects of cluster of differentiation 4 (CD4)+ T lymphocytes, inflammatory indicators, and glucocorticoid treatment on viral nucleic acid clearance were analyzed.@*Results@#In the 292 confirmed cases, 66 patients recovered after treatment and were included in our study. In total, 28 (42.4%) women and 38 men (57.6%) with a median age of 44.0 (34.0–62.0) years were analyzed. After in-hospital treatment, patients’ inflammatory indicators decreased with improved clinical condition. The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5 (6.0–11.0) days. By February 10, 2020, 11 convalescent patients (16.7%) still tested positive for viral RNA from stool specimens and the other 55 patients’ stool specimens were negative for 2019-nCoV following a median duration of 11.0 (9.0–16.0) days after symptom onset. Among these 55 patients, 43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs, with a median delay of 2.0 (1.0–4.0) days. Results for only four (6.9%) urine samples were positive for viral nucleic acid out of 58 cases; viral RNA was still present in three patients’ urine specimens after throat swabs were negative. Using a multiple linear regression model (F=2.669, P=0.044, and adjusted R2=0.122), the analysis showed that the CD4+ T lymphocyte count may help predict the duration of viral RNA detection in patients’ stools (t=-2.699, P=0.010). The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (15 days vs 8.0 days, respectively; t=2.550, P=0.013) and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (20 days vs 11 days, respectively; t=4.631, P <0.001). There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results (P >0.05).@*Conclusions@#In brief, as the clearance of viral RNA in patients’ stools was delayed compared to that in oropharyngeal swabs, it is important to identify viral RNA in feces during convalescence. Because of the delayed clearance of viral RNA in the glucocorticoid treatment group, glucocorticoids are not recommended in the treatment of COVID-19, especially for mild disease. The duration of RNA detection may relate to host cell immunity.

9.
Asian Journal of Andrology ; (6): 196-200, 2019.
Article in Chinese | WPRIM | ID: wpr-842580

ABSTRACT

The clinical predictive factors for malignant testicular histology remain unclear because of the low prevalence. Therefore, the aim of this study was to investigate predictors of malignant histology for testicular masses and decide more testis-sparing surgeries before surgery. This retrospective study enrolled 325 consecutive testicular mass patients who underwent radical orchiectomy (310/325) or testicular preserving surgery (15/325) from January 2001 to June 2016. The clinicopathological factors, including tumor diameter, cryptorchidism history, ultrasound findings, serum alpha-fetoprotein, and human chorionic gonadotropin (HCG) levels, were collected retrospectively for statistical analysis. A predictive nomogram was also generated to evaluate the quantitative probability. Among all patients, 247 (76.0%) were diagnosed with a malignant testicular tumor and 78 (24.0%) with benign histology. Larger tumor diameter (per cm increased, hazard ratio [HR] = 1.284, P = 0.036), lower ultrasound echo (HR = 3.191, P = 0.001), higher ultrasound blood flow (HR = 3.320, P < 0.001), and abnormal blood HCG (HR = 10.550, P < 0.001) were significant predictive factors for malignant disease in all testicular mass patients. The nomogram generated was well calibrated for all predictions of malignant probability, and the accuracy of the model nomogram measured by Harrell's C statistic (C-index) was 0.92. According to our data, the proportion of patients who underwent radical orchiectomy for benign tumors (24.0%) was much larger than generally believed (10.0%). Our results indicated that the diameter, ultrasonic echo, ultrasonic blood flow, and serum HCG levels could predict the malignancy in testicular mass patients.

10.
Article in Chinese | WPRIM | ID: wpr-802357

ABSTRACT

The common diseases in pediatrics department include respiratory diseases, digestive diseases, immune system diseases, and skin system diseases. Bronchitis, bronchial asthma, pneumonia and other respiratory diseases are common pediatric diseases, mainly with the symptoms of fever, cough, and runny nose, and are mostly related to children's physical weakness. Pediatric digestive diseases mainly include anorexia, vomiting, diarrhea and constipation. Skin system diseases mainly include tinea diseases such as tinea capitis, tinea pedis, and tinea corporis, allergic diseases such as urticaria and eczema, scorpions, sunburn and other skin diseases. Children are special groups for drug use, as their body is in the stage of growth and development and their organs are not yet mature, with strong susceptibility to disease, low stress ability, and not sensitive to drug reactions. Therefore, special requirements shall be noticed on the drug use and dosage. Children are the future of the country, but we have so many problems in pediatric drug use. It is worth pondering about pediatric drug use. Chinese patent medicine is a traditional Chinese medicine preparation in the forms of pills, powder, cream, pellet, and oral liquid, which is processed according to the laws and prescriptions of traditional Chinese medicine and the rule of syndrome differentiation and treatment experience, mostly of a compound preparation. This is the essence of medical practice after thousands of years of experience. At present, the commonly used dosage forms for Chinese patent medicine are tablets, pills, capsules, oral liquids and powders. Pediatric Chinese patent medicines have the advantages of mild nature, ease of use, stable content, controllable dose-effect, and exact curative effect, so they are widely used in clinical applications. In order to ensure the effectiveness and safety of pediatric Chinese patent medicine, we should strictly grasp some considerations on pediatric Chinese patent medicine due to the particularity of pediatric patients. This paper would analyze the problems in the application of pediatric Chinese patent medicines and the corresponding countermeasures to improve the accessibility of pediatric medication.

11.
Article in Chinese | WPRIM | ID: wpr-802255

ABSTRACT

With the implementation of the national "The Belt and Road" strategy,the international exchange of Chinese medicine is increasing day by day,and foreign drug resources provide a vast space for the development of traditional Chinese medicine(TCM).The introduction of foreign high-quality resources to promote the development of TCM has become the mission of the times to TCM practitioners.In this paper,the successful cases of herbalization of foreign drugs were analyzed.From the three aspects of the image thinking,the original application,the clinical and experimental validation,TCM was recognized and the preliminary research method of herbalization of the foreign medicines was put forward.Through the repeated exploration mode of "theoretical discussion(literature research+field investigation)→experimental verification→clinical practice",the performance of foreign drugs was investigated,providing reference for the research method of herbalization of foreign drugs.

12.
Article in Chinese | WPRIM | ID: wpr-802234

ABSTRACT

Objective: To study the effect of Rosae Chinensis Flos total flavones(RCTF) on the focal cerebral ischemia-reperfusion model in rats, in order to preliminarily explore the mechanism of action. Method: Rats were randomly divided into sham-operated group, model group, large, medium, and low-dose RCTF group(200,100,50 mg ·kg-1) and positive group[Nimodipine group(20 mg ·kg-1) and Naoluotong group (500 mg ·kg-1)]. After 7 days of continuous administration, 1 hour later after the last administration, the middle cerebral artery middle cerebral artery occlusion (MCAO) model was duplicated. After 2 hours of modeling, perfusion was performed for 22 hours. Mortality and neurological deficits were scored. Serum S-100β was detected; brain tissue malondialdehyde(MDA), superoxide dismutase (SOD), nitric oxide (NO), nitric oxide synthase (NOS), tumour necrosis factor-α(TNF-α), interleukin-1β(IL-1β), intercellular adhesion molecule-1(ICAM-1), adenosine triphosphate (ATP)ase were measured. The brain tissue morphological changes were observed. Result: The rat model of focal cerebral ischemia and reperfusion was successfully replicated. Compared with the model group, RCTF in large, medium, and low-dose RCTF group significantly decreased the score of neurological deficit in rats (Pβ in serum (PPP+K+-ATPase, Mg2+-ATPase, and Ca2+ in brain tissue (Pα content, IL-1β, ICAM-1 content in brain tissue (PPConclusion: RCTF have a protective effect on cerebral ischemia-reperfusion injury in rats. The mechanism may be related to the resistance of anti-free radicals, the reduction of inflammation in brain tissue and the improvement of brain energy metabolism after cerebral ischemia reperfusion injury.

13.
Article in Chinese | WPRIM | ID: wpr-802114

ABSTRACT

Uterine dysplasia or naive uterus mainly refers to a pathological state in which the uterus volume is significantly smaller than normal after adolescence. It is a common gynecological disease, which is caused by low levels of hormones during development process. The main symptoms are delayed menstruation, scanty menstruation, dysmenorrhea and even amenorrhea, and often manifested as infertility after marriage. The article summarizes existing animal models of uterine dysplasia based on clinical symptom characteristics of uterine dysplasia according to clinical diagnostic standard of traditional Chinese medicine (TCM) and western medicine. According to etiology and pathogenesis of uterine dysplasia and diagnostic criteria of TCM and Western medicine, advantages and disadvantages and coincidence of animal models with characteristics of uterine dysplasia and clinical symptoms of uterine dysplasia were proposed. The corresponding animal model evaluation index system and existing uterine dysplasia animal models were proposed to improve ideas and methods. At present, there are not many methods for establishing uterus dysplasia models. The existing models of uterine dysplasia are pathological models based on western medicine indexes. The existing models reflect clinical situations of uterine dysplasia in some aspects, but there is no evaluation index system of uterine dysplasia model and animal model reflecting cause of TCM. Based on existing single-factor animal models, a composite animal model with clinical conditions and similar typical symptoms of human uterine dysplasia is established, which is more consistent with characteristics of clinical symptoms. At same time, it is focus of future researches to improve evaluation index system of uterine animal models and establish a combination model of dysplasia of uterus with TCM syndromes.

14.
Article in Chinese | WPRIM | ID: wpr-802089

ABSTRACT

With a clear efficacy in external treatment of diseases, traditional Chinese medicine(TCM) has been widely applied in surgery, in acute, pediatric, gynecological, internal medicine and other departments. Its advantages include easy use, direct access to lesions, and prevent of the first-pass effect of the liver. However, its mechanism of action is still unclear, which impacts its clinical promotion. This article makes analysis and summary on the clinical application of TCM in external treatment of diseases, the characteristics of commonly used TCM in treatment of diseases, and the relationship of the common externally treated diseases and the "neurological-endocrine-immune network". The findings showed that TCM for external treatment were widely used, with exact curative effects; the pathogenesis of commonly used TCM for externally treating diseases is closely related to the "neuro-endocrine-immune network". Moreover, the modern pharmacological effects of TCM for externally treating diseases were found to be 100%related to the "neuro-endocrine-immune network". According to the analysis of the relationship between the common diseases externally treated with TCM and the "neuro-endocrine-immune network", the pathogenesis of the treatment with TCM is closely related to the "neuro-endocrine-immune network". Therefore, we believe that the "neuro-endocrine-immune network" system is probably one of the main mechanisms of action of TCMs for externally treating diseases. The verification of this mechanism requires the joint efforts of various departments in conducting clinical or experimental verification in the future, so as to provide a reference for clarifying the mechanism of TCM for external use, and basis for the promotion and application of TCM for external use.

15.
Article in Chinese | WPRIM | ID: wpr-801749

ABSTRACT

Traditional Chinese medicine(TCM) and its components play a role in the field of anti-hepatocarcinoma. The definition of its mechanism of action in autophagy contributes to the development of TCM in the field of anti-hepatocarcinoma. In this paper, we summarized reports on the autophagy of liver cancer cells induced by TCM and its active ingredients, including those on promoting apoptosis and cycle inhibition induced by autophagy and inhibiting autophagy to block tumor cell cycle, but with a lack of systematic summarization. In this paper, according to different effect of TCM on autophagy induced by hepatocarcinoma, the TCM and its components were inductively analyzed in four aspects:inducing killing autophagy, inhibiting protective autophagy, inducing protective autophagy in liver cancer, and inducing unclear autophagy. According to the findings, TCMs and components that cause killing autophagy can inhibit the occurrence of autophagy, arrest cell cycle, induce cell senescence or promote apoptosis. TCMs and components that inhibit protective autophagy can inhibit protective autophagy and hepatoma cell proliferation. TCMs and components that induce protective autophagy have a significant anti-hepatocarcinoma effect, shall be considered to be combined with autophagy inhibitors to enhance the lethality of drugs on liver cancer cells, and become a new way for such drugs to treat liver cancer. TCMs and components with an unclear inductive effect shall be first identified for their type of autophagy, then combined with autophagy agonists or blockers according to the type of autophagy to enhance their anti-liver cancer effect, and provide a new clinical therapeutic approach for liver cancer. In the aspect of autophagy, this study not only reveals the molecular mechanism of anti-hepatocarcinoma of TCM, but also makes it a new way to study anti-hepatocarcinoma by TCM.

16.
Article in Chinese | WPRIM | ID: wpr-801721

ABSTRACT

The gut microbiome is a unique ecosystem, known as the "forgotten organ" of the human body, and the "second genome" of human. Gut microbiome imbalance is associated with many central nervous system diseases such as Parkinson's disease, Alzheimer's disease, schizophrenia and disseminated sclerosis. Stroke is characterized by high morbidity, recurrence, mortality, and disability. Gut microbiome plays a key role in the occurrence and development of stroke, which can further affect the onset of stroke by affecting the body's absorption, metabolism, blood pressure, blood sugar, blood lipids and atherosclerotic plaque. In Chinese medicine, it is believed that the spleen and stomach qi and blood flow loss, the Yin and yang imbalance, the body's physiological dysfunction, metaplasia "wind, fire, phlegm, deficiency, silt" and other pathological products, can cause the occurrence of stroke. The spleen and stomach are mainly involved for decomposing food, transporting and transforming nutrients from foodstuff, and the gut microbiome affect the digestion and absorption of the diet. The function of gut microbiome in modern research is related to the dysfunction of the spleen and stomach in Chinese medicine. Therefore, adjusting the homeostasis of the gut microbiome can be used as a potential intervention target to prevent and treat ischemic stroke. Traditional Chinese medicine(TCM) intervention has already achieved good results in stroke, and whether it is related to the regulation effect of gut microbiome is worthy of further research in the future. At the same time, the research progress of active ingredients in TCM (berberine, baicalin, resveratrol, et al), single TCM prescriptions (Salviae Miltiorrhizae Radix Et Rhizoma, Rhodiolae Crenulatae Radix Et Rhizoma, et al) and compound TCM prescriptions (Buyang Huanwu Tang, Naoxintong capsule, Buzhong Yiqi Tang) in prevention and treatment of cerebral ischemia were reviewed in this study, providing new ways and ideas for the prevention of ischemic stroke and development of new therapies.

17.
Article in Chinese | WPRIM | ID: wpr-850934

ABSTRACT

Traditional Chinese medicine animal models are widely used in the field of traditional Chinese medicine research. The combination of disease and syndrome models has become the trend of the development of traditional Chinese medicine animal models. In this paper, we find that model manufacturing still exists problems as following through literature review: the selected animals are not in conformity with the constitution of disease population; some diseases lack syndrome manifestation; the correlation between diseases and syndromes are not strong; the disease syndrome combined with animal model evaluation system is deficient and etc. The application of the model exists: ignore the periodicity of the model; ignore the impact of the environment on the animal model; toxicological research has the problem that normal animals are not suitable for TCM toxicology research. This paper proposes from six aspects: construct the animal model that conforms to the constitution of diseased population; expand the scope of use of the disease and syndrome combined animal model; use the theory of traditional Chinese medicine of “five transports and six qi”, “streamer midnight-midday ebb flow”, “seven emotions”, and “six kinky” climate box, and combined with “four diagnosis information” to solve the problem of weak correlation between diseases and syndromes; using “syndrome” index + “disease” indicators to improve the model evaluation criterion from four diagnostic information, biochemical indicators, molecular biology, and etc. Pay attention to the periodicity of the model, and pay particular attention to the influence of the environment on the formation of the animal model syndrome; In the toxicology research, the model animal should be used instead of the normal animal application, and the dosage of the traditional Chinese medicine should be adjusted to improve the efficacy of traditional Chinese medicine. Through the improvement of the above problems, it is expected to provide relevant reference for the improvement of the animal model of Chinese medicine and its correct application.

18.
Article in Chinese | WPRIM | ID: wpr-745267

ABSTRACT

Objective To analyze the distribution characteristics and influencing factors of X-ray diagnostic imaging in Shandong province,and to estimate the application frequency of X-ray diagnostic imaging in the province,and provide data support for X-ray equipment.Methods A random sampliug method was used to extract 32 medical institutions as respondents from 10 prefecture-level cities in Shandong province.The basic information of medical institutions and the age,sex,examination and procedure of the subjects were analyzed.The distribution of the X-ray application was analyzed and estimated by using a multiple linear regression model.Results Totally 14 694 085 subjects were surveyed,and the proportion of male and female in the sample was not completely uniform.A total of 2 099 155 X-ray diagnostic information was collected in 2016,and the frequency of conventional radiography was the highest,accounting for 59.49%.The next was CT examination,accounting for 28.34%.The frequency of the two examinations showed an increasing trend with the age of subjects.For the total frequency of conventional diagnostic radiography and CT examination,the tertiary hospitals accounted for the highest proportion of the total,up to 52.13%,while the secondary hospitals accounted for the relatively low proportion of 30.09%,and the primary hospitals the lowest with 17.77%.The chest radiography had the highest proportion in conventional radiography accounting for 32.79% of the total frequency of X-ray diagnostic imaging,and the head procedure had the highest proportion in CT examination,accounting for 10.07% of the total frequency of X-ray diagnostic imaging.The fluoroscopy,mammography and dental radiography were mainly concentrated in the tertiary hospitals,and the primary hospitals had mainly radiography.Multiple linear regression models showed that the frequency of application of conventional X-ray diagnostic imaging (including radiography,fluoroscopy,dental radiography and mammography) was positively correlated with equipment quantity,number of outpatient and emergency patients,and tertiary hospitals (t=4.334,3.615,2.339,P< 0.05).CT examination was positively correlated with equipment quantity and the number of inpatient (t =2.167,2.595,P<0.05).The frequency of conventional X-ray diagnostic imaging and CT examination in Shandong province were estimated about 491.17 examinations per 1 000 population and 258.17 examinations per 1 000 population respectively.Conclusions The frequency of X-ray exposure in Shandong province increased significantly compared with that during the " 9th Five-Year Plan" period.All relevant departments should take effective measures to strengthen medical radiation protection and reduce radiation risk.

19.
Article in Chinese | WPRIM | ID: wpr-905545

ABSTRACT

As a novel intervention, whole body periodic acceleration (WBPA) shows a variety of benefits to the cardiovascular system, such as reducing pulmonary arteria hypertension (PAH), improving coronary flow reserve (CFR) and increasing blood perfusion of organs as well as tissues. The underlying mechanisms of WBPA may lie in the increase of blood flow rate and endothelium shear stress, activation of phosphoinositide 3-kinase/serine threonine kinase (PI3K-Akt) and mitogen extracellular signal regulated kinases/extracellular signal regulated kinase (MEK-ERK1/2) signal pathway and the release of nitric oxide.

20.
Article in Chinese | WPRIM | ID: wpr-708087

ABSTRACT

Objective To estimate the absorbed dose and effective dose to the examined adult patients during digital tomosynthesis and to provide reference data for radiation dosimetry.Methods The phantom experiments were grouped according to the examined site(main beam scanned site),and the data displayed in real time during digital tomosynthesis are used as conditions for the phantom experiments.The effective doses to the examined patients were estimated on the basis of phantom scanning and tissue-absorbed dose calculation.Results During digital tomosynthesis,the effective doses to the examined patients of various groups were 0.524 mSv for head,0.736 mSv for cervical spine,2.719 mSv for thoracic vertebra,1.810 mSv for chest,1.240 mSv for lumbar spine,2.317 mSv for abdomen and 2.316 mSv for pelvis,respectively.Conclusions During digital tomography,the highest value of effective doses was estimated to be 2.719 mSv in thoracic vertebra group,followed by abdominal group 2.317 mSv and pelvic group 2.316 mS,with the lowest 0.524 mSv in head group.The main factors influencing the effective dose include tube voltage,total mAs,irradiation field size,main beam irradiation range,and the number of tissues or organs in scanned range.

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