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Article in Chinese | WPRIM | ID: wpr-702612

ABSTRACT

Objective To investigate the bacterial resistance profile of clinical isolates collected in the hospitals across Chuzhou in 2016. Methods Antimicrobial susceptibility testing was carried out by Kirby-Bauer method. The data were analyzed using WHONET 5.6 software according to CLSI 2015 breakpoints. Results A total of 5 465 clinical isolates were collected during 2016, of which gram positive organisms and gram negative organisms accounted for 25.9% (1 416/5 465) and 74.1% (4 049/5 465), respectively. Prevalence of MRSA was 37.6% among S. aureus and the prevalence of MRCNS was 78.1% in CNS. All Staphylococcus, E. faecalis and E. faecium isolates were sensitive to vancomycin and linezolid. The prevalence of extended spectrum-lactamases (ESBLs) positive strains was 51.2% in E. coli, 23.4% in Klebsiella spp. (K. pneumoniae and K. oxytoca), and 23.6% in P. mirabilis isolates, respectively. The Enterobacteriaceae strains were highly sensitive to carbapenems. The percentage of the P. aeruginosa isolates resistant to the antimicrobials tested was lower than 30%. The percentage of the Acinetobacter strains resistant to meropenem and imipenem was 65.6% and 67.4%, respectively. Conclusions The situation of antibiotic resistance is still very serious, especially multi-drug or pan-drug resistant strains, which is of great concern.

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