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1.
Acta Pharmaceutica Sinica B ; (6): 4511-4522, 2023.
Article in English | WPRIM | ID: wpr-1011181

ABSTRACT

Developing new therapeutic agents for cancer immunotherapy is highly demanding due to the low response ratio of PD-1/PD-L1 blockade in cancer patients. Here, we discovered that the novel immune checkpoint VISTA is highly expressed on a variety of tumor-infiltrating immune cells, especially myeloid derived suppressor cells (MDSCs) and CD8+ T cells. Then, peptide C1 with binding affinity to VISTA was developed by phage displayed bio-panning technique, and its mutant peptide VS3 was obtained by molecular docking based mutation. Peptide VS3 could bind VISTA with high affinity and block its interaction with ligand PSGL-1 under acidic condition, and elicit anti-tumor activity in vivo. The peptide DVS3-Pal was further designed by d-amino acid substitution and fatty acid modification, which exhibited strong proteolytic stability and significant anti-tumor activity through enhancing CD8+ T cell function and decreasing MDSCs infiltration. This is the first study to develop peptides to block VISTA/PSGL-1 interaction, which could act as promising candidates for cancer immunotherapy.

2.
Chinese Journal of Radiological Medicine and Protection ; (12): 94-100, 2023.
Article in Chinese | WPRIM | ID: wpr-993057

ABSTRACT

Objective:To analyze the correlation between the volume of irradiated pelvic bone marrow and acute hematologic toxicity (HT), in order to provide clinical data to reduce the risk of acute HT and optimize the radiotherapy plan.Methods:From October 2017 to May 2019, 41 LARC patients who received neoadjuvant concurrent chemoradiotherapy (CCRT) were retrospectively reviewed in our center. All patients were treated with 5-field intensity-modulated radiotherapy (IMRT), and the prescription dose delivered to PTV was 45-50.4 Gy in 25-28 fractions. Capecitabine or 5-fluorouracil (5-FU) wasadministered daily 5 days a week during radiotherapy. Different HTswere recorded according to National Cancer Institute Common Toxicity Criteria Version 5.0 (NCI-CTC.V5.0) based on laboratory tests. The volume of PBM or each site (coxal, sacrum, femoral) receiving more than x Gy refers to as TVx, CVx, SVx, and FVx, respectively. Logistic regression was performed to evaluate the association between the volume of irradiated pelvic bone marrow and different HT. Generalized additive model (GAM) and piecewise regression were used to further analyze the possible nonlinear relationship and threshold effect between them. Results:Multivariate logistic regression analysis showed that low-dose of irradiated total pelvic bone marrow volume ( TV5) and coxal bone marrow volume ( CV5, CV10) were significantly correlated with Grade ≥2 leukopenia( P<0.05). There was a significant negative correlation between the sacrum bone marrow volume ( SV5, SV10) and Grade ≥2 leukopenia ( P<0.05). A thresholdeffect has been observed between CV10 and Grade ≥2 leukopenia by Generalized additive model (GAM) and piecewise linear regression. The threshold between CV10 and Grade ≥2 leukopenia was 575 ml, OR (95% CI) was 1.85 (1.08, 3.16). Conclusions:In neoadjuvant IMRT of rectal cancer, CV is a better predictor of acute HT induced by CCRT than TV. The irradiated volume of CV associated with acute HT was mainly low-dose levels ( CV5, CV10). The thresholds of our study ( CV10= 575 ml) could be a good reference for the optimization of the radiotherapy plan.

3.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (12): 478-482, 2023.
Article in Chinese | WPRIM | ID: wpr-982771

ABSTRACT

Objective:The auditory and speech rehabilitation effects were assessed by the Categories of Auditory Performance(CAP) and the speech intelligibility rating scale(SIR) after cochlear implantation(CI) in prelingually elderly patients by telephone follow-up or face-to-face conversation. Methods:The clinical data of the prelingually deaf patients who underwent unilateral CI in the Department of Otorhinolaryngology and Head and Neck Surgery, Shanxi People's Hospital, from December 2016 to December 2021 were collected. Thirty-eight patients were divided into Group A(SIR 1, 17 cases), Group B(SIR 2, 10 cases) and Group C(SIR 3, 11 cases) according to the preoperative SIR Score. Nineteen patients with post-lingual hearing impairment were selected as the control group(Group D, 19 cases). The effects of hearing and speech rehabilitation were evaluated using CAP and SIR Scores before surgery, 6 months after startup, and 1 year after startup. Results:There were no significant differences in CAP scores among the three groups of patients with prelingually deaf patients at 6 months and 1 year after startup(P>0.05), but there were significant differences between group A and group D at 6 months and 1 year after startup(P<0.05); the SIR Score of group A had statistical difference before surgery and 6 months after startup(P<0.05), group B had statistical difference before surgery and 1 year after startup(P<0.05), and group C and D had no statistical difference before surgery and 6 months and 1 year after startup, respectively(P>0.05). Conclusion:For the prelingually deaf elderly patients, hearing will develop rapidly 6 months after startup, and the effect of postoperative auditory rehabilitation was positively correlated with the preoperative speech ability. In the aspect of speech, the prelingually dear elderly patients who have poor preoperative speech ability could benefit more from CI early after surgery. CI is not contraindicated in prelingually deaf elderly patients, even those with poor preoperative speech function.


Subject(s)
Humans , Aged , Cochlear Implantation/methods , Cochlear Implants , Speech Perception , Deafness/rehabilitation , Hearing Tests , Speech Intelligibility , Treatment Outcome
4.
Chinese Journal of Hospital Administration ; (12): 327-331, 2022.
Article in Chinese | WPRIM | ID: wpr-958783

ABSTRACT

Promoting balanced distribution of medical resources and realizing high-quality sharing of basic medical services between urban and rural areas are an important part of common prosperity. Huzhou urban medical alliance was a new urban and rural of medical alliance mode based on level 4 vertical integration, which played an important role in the whole evolution process of the medical alliance. This medical alliance had not only broken through the " integration of counties" but also explored the " integration of cities" . It was a bridge connecting counties and cities, which was of great significance in narrowing the gap between urban and rural medical health services. The construction of urban medical alliance took digital transformation and systematic integration as two breakthroughs to comprehensively promote the upgrade of energy efficiency and benefit stacking of health governance. In 2021, the grass-roots medical utilization rate and county-level medical utilization rate were 72.7% and 90.6%. In 2020, the average hospitalization cost(8 726.7 yuan)and the average outpatient and emergency expenses(239.6 yuan)of public hospitals were 25.0% and 8.6% lower than the average level of Zhejiang Province, respectively. Although Huzhou city had broken through the restrictions of administrative divisions and actively promoted the construction of the medical alliance, and achieved phased results, there were still structural defects and institutional difficulties. In order to solve these problems, the author proposed to promote the improvement of governance structure and optimization of governance system through " three governance" and " three characteristics" , and then promote the high-quality development of urban medical alliances.

5.
Acta Pharmaceutica Sinica B ; (6): 1390-1405, 2022.
Article in English | WPRIM | ID: wpr-929372

ABSTRACT

Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this protein-protein interaction (PPI) may offer promising avenues for selective CDK9 inhibition. Herein, we designed and generated a library of metal complexes bearing the 7-chloro-2-phenylquinoline CˆN ligand and tested their activity against the CDK9-cyclin T1 PPI. Complex 1 bound to CDK9 via an enthalpically-driven binding mode, leading to disruption of the CDK9-cyclin T1 interaction in vitro and in cellulo. Importantly, complex 1 showed promising anti-metastatic activity against TNBC allografts in mice and was comparably active compared to cisplatin. To our knowledge, 1 is the first CDK9-cyclin T1 PPI inhibitor with anti-metastatic activity against TNBC. Complex 1 could serve as a new platform for the future design of more efficacious kinase inhibitors against cancer, including TNBC.

6.
Journal of Clinical Hepatology ; (12): 927-930, 2022.
Article in Chinese | WPRIM | ID: wpr-923311

ABSTRACT

Particulate matter 2.5 (PM2.5), as one of the main components of atmospheric particulate matter, has become an important factor affecting people's health; however, there are relatively few studies on the association of PM2.5 with the development and progression of liver cancer. This article reviews the epidemiological study of PM2.5 and liver cancer, summarizes the mechanisms of PM2.5 causing liver cancer (including changing enzyme activity, affecting gene expression, inducing endoplasmic mesh stress, causing liver fat degeneration, and leading to liver fibrosis), and discusses the influence of PM2.5 exposure on the prognosis of liver cancer.

7.
Chinese Journal of Hepatobiliary Surgery ; (12): 396-400, 2022.
Article in Chinese | WPRIM | ID: wpr-932801

ABSTRACT

Celiac axis (CA) is an important branch of the abdominal aorta which is also called celiac artery. CA is consisted with left gastric artery, common hepatic artery and splenic artery. However, there are many variants of CA branches, leading to different types. At present, CA types of branches have been identified, however, due to the different background and purposes, it is difficult to make it consistent. This review summarized the research status of domestic and foreign classification methods of CA branches which may benefit the clinic application.

8.
Chinese Journal of Digestive Endoscopy ; (12): 127-132, 2021.
Article in Chinese | WPRIM | ID: wpr-885703

ABSTRACT

Objective:To evaluate the clinical efficacy and safety of SpyGlass-guided laser lithotripsy for large common bile duct (CBD) stones with diameter>2 cm.Methods:From August 2015 to August 2018, a total of 157 patients with large CBD stones at the First Affiliated Hospital of Shandong First Medical University who met the inclusion criteria were randomly divided into SpyGlass group ( n=78, underwent SpyGlass-guided laser lithotripsy) and laparoscopic common bile duct exploration (LCBDE) group ( n=79, underwent LCBDE) by using random numbers. Non-inferiority test was used for rates of one-time stone removal and total stone removal, and the non-inferiority margin was set to 10%. The transform rate, incidence of short-term complications, hospital stay, and quality of life (assessed by the gastrointestinal quality of life index) were compared between the two groups. Results:The total success rates of stone clearance were 92.3% (72/78) and 96.2% (76/79) in the SpyGlass group and LCBDE group, respectively ( P=0.023), with valid non-inferiority hypothesis. The one-time stone removal rates were 83.3% (65/78) and 96.2% (76/79), respectively ( P=0.124), with invalid non-inferiority hypothesis. There were no significant differences in the incidence of transform [7.7% (6/78) VS 3.8% (3/79), P=0.294] or short-term complications [5.1% (4/78) VS 10.1% (8/79), P=0.246] between the two groups. Compared with the LCBDE group, the SpyGlass group had a shorter hospital stay (5.65±0.94 d VS 8.84±1.54 d, P=0.001) and higher scores of gastrointestinal quality of life index (1 month after operation: 99.85±4.36 VS 91.51±5.47, P=0.001; 3 months after operation: 131.24±3.32 VS 112.32±7.77, P=0.001). Conclusion:For large CBD stones, the efficacy of SpyGlass-guided laser lithotripsy is not inferior to LCBDE, and it is less invasive. In the future, SpyGlass-guided laser lithotripsy could be an important option for the treatment of large CBD stones.

9.
Acta Pharmaceutica Sinica B ; (6): 1047-1060, 2020.
Article in English | WPRIM | ID: wpr-828825

ABSTRACT

PD-1 and CTLA-4 antibodies offer great hope for cancer immunotherapy. However, many patients are incapable of responding to PD-1 and CTLA-4 blockade and show low response rates due to insufficient immune activation. The combination of checkpoint blockers has been proposed to increase the response rates. Besides, antibody drugs have disadvantages such as inclined to cause immune-related adverse events and infiltration problems. In this study, we developed a cyclic peptide C25 by using Ph.D.-C7C phage display technology targeting LAG-3. As a result, C25 showed a relative high affinity with human LAG-3 protein and could effectively interfere the binding between LAG-3 and HLA-DR (MHC-II). Additionally, C25 could significantly stimulate CD8 T cell activation in human PBMCs. The results also demonstrated that C25 could inhibit tumor growth of CT26, B16 and B16-OVA bearing mice, and the infiltration of CD8 T cells was significantly increased while FOXP3 Tregs significantly decreased in the tumor site. Furthermore, the secretion of IFN- by CD8 T cells in spleen, draining lymph nodes and especially in the tumors was promoted. Simultaneously, we exploited T cells depletion models to study the anti-tumor mechanisms for C25 peptide, and the results combined with MTT assay confirmed that C25 exerted anti-tumor effects CD8 T cells but not direct killing. In conclusion, cyclic peptide C25 provides a rationale for targeting the immune checkpoint, by blockade of LAG-3/HLA-DR interaction in order to enhance anti-tumor immunity, and C25 may provide an alternative for cancer immunotherapy besides antibody drugs.

10.
Chinese Journal of Orthopaedics ; (12): 433-440, 2020.
Article in Chinese | WPRIM | ID: wpr-868985

ABSTRACT

Objective:To compare the effects of patellar position on the balance of soft tissue during the operation and the postoperative outcomes in minimally invasive total knee arthroplasty via a midvastus approach.Methods:From December 2018 to February 2019, a total of 55 patients were enrolled for primary total knee arthroplasty via a midvastus approach. All patients were randomly divided into 2 groups by random number table. During the operation, the gap balance technique was used with patella reduced or subluxated to complete the osteotomy and balance of soft tissue. The changes of gap and varus-valgus angle were compared between the patellar reduction group and the patellar subluxation group in both extension and flexion position. These data were also compared before and after reducing patellar in the patellar subluxation group. Furthermore, the differences of femoral prosthesis rotation, mechanical femoral axis to tibial axis angle, Knee Society score (KSS), visual analogue scale (VAS) and range of motion (ROM) were compared between the two groups.Results:All patients finished 6 months follow-up, including 27 patients in the patellar reduction group and 28 patients in the patellar subluxation group. After osteotomy and soft tissue balance during the operation, there was no significant difference in gap and varus-valgus angle between two groups in either extension or flexion position. While in the patellar subluxation group, the flexion gap was 10.5±0.3 mm with patella subluxated, less than 11.0 ± 0.3 mm after reducing the patella. The varus-valgus angle was 1.5±0.3 with patella subluxated, less than 2.3±0.4 degree after reducing the patella. The difference was statistically significant ( t=4.180, P<0.001; t=7.642, P<0.001). There was no significant difference in extension gap and varus-valgus angle before and after patella reduction in the patellar subluxation group ( P>0.05). The rotation angle of the femoral component in the patellar subluxation group was -0.49°±1.2°, and the external rotation angle was smaller than that in the patellar reduction group (0.24°±1.3°). The difference was statistically significant ( t=2.116, P=0.039). At one month after operation, ROM of the patellar reduction group was 109.6°±8.5° which was higher than that of the patellar subluxation group (104.9°±8.6°, t=2.048, P=0.046). There was no significant difference in ROM between the two groups at 3 and 6 months ( P>0.05). Moreover, there was no significant difference in KSS and VAS at 1, 3 and 6 months after operation ( P>0.05). Conclusion:In the minimally invasive total knee arthroplasty, it is suggested to balance the soft tissue as much as possible with the patellar reduced. Otherwise, the consequence of increased flexion space, increased varus and increased internal rotation of femoral prosthesis should be considered. The patients undergoing soft tissue balance with patella reduced have better ROM in the early stage postoperatively.

11.
Chinese Journal of Radiological Medicine and Protection ; (12): 740-745, 2020.
Article in Chinese | WPRIM | ID: wpr-868522

ABSTRACT

Objective:To investigate the correlation between the X-ray cross-complementary gene 1 (XRCC1) rs25487 gene polymorphism and the effect of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC).Methods:This research was a prospective cohort study consisting of 55 patients with LARC who were treated in the Affiliated Hospital, Guizhou Cancer Hospital of Guizhou Medical University from August 2018 to July 2019. The XRCC1 rs25487 genotype was detected, followed by neoadjuvant chemoradiotherapy. The logistic regression with adjusted confounding factors was used to analyze the relationship between down-staging of T-stage and N-stage and XRCC1 rs25487 gene polymorphism. The stratified analysis was used to explore interactions of neutrophil lymphocyte ratio (NLR) based on logistic regression.Results:The frequencies of all genotypes were in accordance with Hardy-Weinberg equilibrium. After adjusting confounding factors, compared to patients with AA genotype, patients with GG genotype had lower rate of down-staging of T-stage after neoadjuvant radiotherapy ( OR=0.1, P<0.05). However, there was no statistically significant difference between GA and AA genotypes ( P>0.05). There was interactions between AA/GA genotypes and NLR, which affected the down-staging of T-stage after radiotherapy. Conclusions:XRCC1 rs25487 gene polymorphism is associated with the efficacy of neoadjuvant radiotherapy and concurrent system chemotherapy in patients with LARC, which may be used as a predictor of the efficacy of neoadjuvant intensive therapy.

12.
Journal of Chinese Physician ; (12): 1014-1017, 2020.
Article in Chinese | WPRIM | ID: wpr-867342

ABSTRACT

Objective:To explore application value of transvaginal ultrasound elastography in differential diagnosis of uterine fibroids and adenomyoma.Methods:A retrospective analysis was performed on clinical case data and imaging data of transvaginal ultrasound elastography from 54 uterine fibroids patients and 46 adenomyoma patients confirmed by pathology who were admitted to the Hospital of PLA the 81 st Group Army from January 2017 to February 2019. To compare the diagnostic value, elastography parameters and imaging characteristics of real-time ultrasound elastography in patients with uterine leiomyoma and adenomyoma. Results:Among 54 patients with uterine fibroids, there were 49 cases confirmed by real-time ultrasound elastography, with diagnostic coincidence rate 90.74% (49/54). Among 46 patients with adenomyoma, there were 40 cases confirmed by real-time ultrasound elastography, with diagnostic coincidence rate 86.96% (40/46). The resistance index of uterine artery in uterine fibroid group was lower than that in adenomyoma group, while strain ratio (SR) between normal muscle layer and lesion was higher than that in adenomyoma group, with statistically significant difference ( P<0.05). The real-time ultrasound elastography of uterine fibroids was characterized by regular shape, common rounded shape, and clear boundary. The interior of fibroids was basically blue-green inter-image mainly on blue color. There was green-yellow or red capsule around. The real-time ultrasound elastography of uterine adenomyoma was characterized by irregular shape, unclear boundary, greener color than normal muscle wall, and even yellow-red-green inter-images. Conclusions:There is certain clinical value of transvaginal ultrasound elastography in differential diagnosis of uterine fibroids and adenomyoma.

13.
Chinese Journal of Pediatrics ; (12): E011-E011, 2020.
Article in Chinese | WPRIM | ID: wpr-811509

ABSTRACT

Objective@#To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus(2019-nCoV) infection in children from six provinces (autonomous region) in northern China.@*Methods@#A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. The patients were diagnosed between January 25th, 2020 and February 21st, 2020 in 21 hospitals in 17 cities of six provinces(autonomous region) of Shaanxi, Gansu, Ningxia, Hebei, Henan and Shandong.@*Results@#The age of the 31 children with 2019-nCoV infection was 7 years and 1 month (6 months -17 years). Nine cases (29%) were imported cases. Other 21 cases (68%) had contact with confirmed infected adults. One case (3%) had contact with asymptomatic returnees from Wuhan. Among the 31 children, 28 patients (90%) were family cluster cases. The clinical types were asymptomatic type in 4 cases (13%), mild type in 13 cases (42%), and common type in 14 cases (45%). No severe or critical type existed. The most common symptom was fever (n=20, 65%), including 1 case of high fever, 9 cases of moderate fever, 10 cases of low fever. Fever lasted from 1 day to 9 days. The fever of fifteen cases lasted for ≤3 d, while in other 5 cases lasted > 3 d. Other symptoms included cough (n=14, 45%), fatigue (n=3, 10%) and diarrhea (n=3, 9%). Pharyngalgia, runny nose, dizziness, headache and vomiting were rare. In the early stage, the total leukocytes count in peripheral blood decreased in 2 cases (6%), the lymphocytes count decreased in 2 cases (6%), and the platelet count increased in 2 cases (6%).Elevation of C-reactive protein (10%, 3/30), erythrocyte sedimentation rate(19%,4/21), procalcitonin(4%,1/28), liver enzyme(22%, 6/27) and muscle enzyme (15%, 4/27) occurred in different proportions. Renal function and blood glucose were normal. There were abnormal chest CT changes in 14 cases, including 9 cases with patchy ground glass opacities and nodules, mostly located in the lower lobe of both lungs near the pleural area. After receiving supportive treatment, the viral nucleic acid turned negative in 25 cases within 7-23 days. Among them, 24 children (77%) recovered and were discharged from hospital. No death occurred.@*Conclusions@#In this case series, 2019-nCoV infections in children from six provinces (autonomous region) in northern China are mainly caused by close family contact. Clinical types are asymptomatic, mild and common types. Clinical manifestations and laboratory examination results are nonspecific. Close contact history of epidemiology, nucleic acid detection and chest imaging are important bases for diagnosis. After general treatment, the short-term prognosis is good.

14.
Acta Pharmaceutica Sinica B ; (6): 537-544, 2019.
Article in English | WPRIM | ID: wpr-774970

ABSTRACT

We report in this study the identification of a natural product-like antagonist () of Vps34 as a potent autophagy modulator structure-based virtual screening. Aurone derivative strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, prevents autophagy in human cells induced either by starvation or by an mTOR inhibitor. modeling and kinetic data revealed that could function as an ATP-competitive inhibitor of Vps34. Moreover, it suppressed autophagy and without inducing heart or liver damage in mice. could be utilized as a new motif for more selective and efficacious antagonists of Vps34 for the potential treatment of autophagy-related human diseases.

15.
Chinese Journal of Microsurgery ; (6): 232-236, 2019.
Article in Chinese | WPRIM | ID: wpr-756318

ABSTRACT

Objective To localise and evaluate the precise position of the shank perforators preoperatively with the CTA and hand-held color Doppler (HHD),then evaluate the clinical efficacy of the method.Methods From April,2013 to June,2017,designed 36 propeller perforator flaps in 36 patients by following methods.Firstly,the CTA test was performed to calculate the parameters of perforator vessel positioning.Secondly,a HHD was typically used to verify the location of perforators found on preoperative CTA.At last,according to the "like with like" principle,the propeller perforator flaps were accurately designed.The regular followed-up was performed.Results All patients were followed-up for 3-24 months after operation.Thirty-six propeller perforator flaps survived,and 3 cases among them showed partial epidermal necrosis and healed after skin grafting.Donor sites were closed primarily in 24 cases,and skin grafting were performed in 12 cases.The skin graft sites survived without necrosis,and the average time of cutting flaps was 45 min.Conclusion By the methods of mapping the perforator propeller flaps with CTA and HHD,the perforator vessel can be positioned more accurately and quickly.The operation time was shortened,and the clinical efficiency can be achieved with the good clinical application values.

16.
Chinese Journal of Orthopaedics ; (12): 935-943, 2019.
Article in Chinese | WPRIM | ID: wpr-755238

ABSTRACT

Objective To compare the difference in imaging and clinical effects between gap balance technique and mea?sured resection technique in total knee arthroplasty (TKA). Methods We recruited 300 patients undertaking TKA from July 2014 to July 2016. TKA were performed by using gap balance technique or measured resection technique randomly. The intraoper?ative rotation of femoral prosthesis, changes of joint line, osteotomy volume, preoperative and postoperative KSS score, WOMAC score, VAS and ROM were compared between the two groups. Results A total of 292 patients were included in the present study, and 248 patients were successfully followed up for 2 years. The operation duration of the gap balance group was 65.9±14.1 min, which was significantly less than that of the measured osteotomy group 70.5±16.5 min (t=2.36, P=0.02). The rotation angle α of the femoral prosthesis measured on CT scan postoperative in gap balance group was 0.67°±1.71°, which was significantly smaller than that of the measured resection technique group 1.25°±2.53°(t=2.12, P=0.03). The external rotation angle β between the oste?otomy plate and femoral posterior condyle line in the gap balance group was 1.25°±1.26°, which was significantly greater than that of the measured resection technique 0.28°±0.19°(t=6.57, P<0.01). The bone cut volume of femoral medial posterior condyle in gap balance group 9.85±1.37 mm showed a statistically difference (t=2.02, P=0.04) compared with that of the measured osteotomy group 9.52±1.19 mm. The KSS score was 83.8±10.2 in the gap balance group after 1 month. It was superior to the measured resec?tion technique group of 80.5±9.4 with statistical significance (t=2.65, P=0.01). The knee ROM was 101.7°±12.7°in the gap bal?ance group at 1 month after surgery, which was better than that in the measured resection technique group 98.2°±11.8°(t=2.25, P=0.03). Conclusion The axis of the femoral prosthesis was more consistent with STEA in the gap balance group of TKA. The gap balance group had better ROM and KSS functional scores at the first month after surgery. However, there was no statistical differ?ence in knee function at the 2?year follow?up between the two groups.

17.
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1793-1797, 2019.
Article in Chinese | WPRIM | ID: wpr-802729

ABSTRACT

Objective@#To investigate the effect and recurrence rate of radiofrequency ablation of low temperature plasma knife in the treatment of patients with early glottal carcinoma.@*Methods@#A total of 64 cases of early glottic carcinoma in the People's Hospital of Shanxi Province from February 2012 to January 2016 were divided into observation group and control group according to the different treatment schemes, with 32 cases in each group.The observation group was treated with radiofrequency ablation of low temperature plasma knife, and the control group was performed with routine larynx cleft surgery.The surgical related indicators and postoperative complications of the two groups were recorded.The phonetic changes (amplitude perturbation, fundamental frequency perturbation and harmonic noise ratio) before and 6 months after operation of two groups were compared.After 2 years of follow-up, the recovery of vocal mucosa in the two groups after 1 year of operation and the recurrence rate of 6 months, 1 year and 2 years after operation of the two groups were statistically recorded.@*Results@#The intraoperative blood loss in the observation group was less than that in the control group(P<0.05), and the operative time and hospital stay observation time in the observation group were shorter than those in the control group(all P<0.05). The incidence rate of postoperative complications in the observation group [9.38% (3/32)] was lower than that in the control group[31.25%(10/32)], and the smoothness rate of the vocal cords at 1 year after operation in the observation group [90.63% (29/32)] was higher than that in the control group[62.50%(20/32)], the difference were statistically significant(χ2=4.730, 7.053, all P<0.05). There were no statistically significant differences in amplitude perturbation, fundamental frequency perturbation and harmonic noise ratio between the two groups(all P>0.05). After operation, the amplitude perturbation and the fundamental frequency perturbation in the observation group were lower than those of the control group, and the harmonic noise ratio was higher than that of the control group, the difference were statistically significant (t=18.618, 4.258, 2.579, all P<0.05). In the observation group, the recurrence rates at 6 months, 1 year and 2 years after operation were lower than those in the control group(χ2=4.598, 6.335, 4.730, all P<0.05).@*Conclusion@#Radiofrequency ablation of low temperature plasma knife in the treatment of patients with early glottal carcinoma can significantly reduce the intraoperative blood loss, shorten the operation time and observation time of postoperative hospital stay, and significantly reduce the incidence of postoperative complications and recurrence rate.It can also improve the patients' voice, and promote the recovery of vocal cord mucosal smooth.Besides, it has remarkable effect, and it has important significance in clinical treatment.

18.
Chinese Journal of Orthopaedics ; (12): 935-943, 2019.
Article in Chinese | WPRIM | ID: wpr-802725

ABSTRACT

Objective@#To compare the difference in imaging and clinical effects between gap balance technique and measured resection technique in total knee arthroplasty (TKA).@*Methods@#We recruited 300 patients undertaking TKA from July 2014 to July 2016. TKA were performed by using gap balance technique or measured resection technique randomly. The intraoperative rotation of femoral prosthesis, changes of joint line, osteotomy volume, preoperative and postoperative KSS score, WOMAC score, VAS and ROM were compared between the two groups.@*Results@#A total of 292 patients were included in the present study, and 248 patients were successfully followed up for 2 years. The operation duration of the gap balance group was 65.9±14.1 min, which was significantly less than that of the measured osteotomy group 70.5±16.5 min (t=2.36, P=0.02). The rotation angle α of the femoral prosthesis measured on CT scan postoperative in gap balance group was 0.67°±1.71°, which was significantly smaller than that of the measured resection technique group 1.25°±2.53° (t=2.12, P=0.03). The external rotation angle β between the osteotomy plate and femoral posterior condyle line in the gap balance group was 1.25°±1.26°, which was significantly greater than that of the measured resection technique 0.28°±0.19° (t=6.57, P<0.01). The bone cut volume of femoral medial posterior condyle in gap balance group 9.85±1.37 mm showed a statistically difference (t=2.02, P=0.04) compared with that of the measured osteotomy group 9.52±1.19 mm. The KSS score was 83.8±10.2 in the gap balance group after 1 month. It was superior to the measured resection technique group of 80.5±9.4 with statistical significance (t=2.65, P=0.01). The knee ROM was 101.7°±12.7° in the gap balance group at 1 month after surgery, which was better than that in the measured resection technique group 98.2°±11.8° (t=2.25, P=0.03).@*Conclusion@#The axis of the femoral prosthesis was more consistent with STEA in the gap balance group of TKA. The gap balance group had better ROM and KSS functional scores at the first month after surgery. However, there was no statistical difference in knee function at the 2-year follow-up between the two groups.

19.
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1793-1797, 2019.
Article in Chinese | WPRIM | ID: wpr-753688

ABSTRACT

Objective To investigate the effect and recurrence rate of radiofrequency ablation of low temperature plasma knife in the treatment of patients with early glottal carcinoma.Methods A total of 64 cases of early glottic carcinoma in the People's Hospital of Shanxi Province from February 2012 to January 2016 were divided into observation group and control group according to the different treatment schemes ,with 32 cases in each group.The observation group was treated with radiofrequency ablation of low temperature plasma knife ,and the control group was performed with routine larynx cleft surgery.The surgical related indicators and postoperative complications of the two groups were recorded.The phonetic changes (amplitude perturbation,fundamental frequency perturbation and harmonic noise ratio ) before and 6 months after operation of two groups were compared.After 2 years of follow -up,the recovery of vocal mucosa in the two groups after 1 year of operation and the recurrence rate of 6 months,1 year and 2 years after operation of the two groups were statistically recorded.Results The intraoperative blood loss in the observation group was less than that in the control group (P<0.05),and the operative time and hospital stay observation time in the observation group were shorter than those in the control group ( all P<0.05).The incidence rate of postoperative complications in the observation group [9.38%(3/32)] was lower than that in the control group [31.25%(10/32)],and the smoothness rate of the vocal cords at 1 year after operation in the observation group [90.63%(29/32)] was higher than that in the control group [62.50%(20/32)],the difference were statistically significant (χ2 =4.730,7.053,all P<0.05).There were no statistically significant differences in amplitude perturbation ,fundamental frequency perturbation and harmonic noise ratio between the two groups (all P>0.05).After operation,the amplitude perturbation and the fundamental frequency perturbation in the observation group were lower than those of the control group,and the harmonic noise ratio was higher than that of the control group , the difference were statistically significant (t=18.618,4.258,2.579,all P<0.05).In the observation group,the recurrence rates at 6 months, 1 year and 2 years after operation were lower than those in the control group ( χ2 =4.598,6.335,4.730,all P<0.05).Conclusion Radiofrequency ablation of low temperature plasma knife in the treatment of patients with early glottal carcinoma can significantly reduce the intraoperative blood loss ,shorten the operation time and observation time of postoperative hospital stay ,and significantly reduce the incidence of postoperative complications and recurrence rate.It can also improve the patients'voice,and promote the recovery of vocal cord mucosal smooth.Besides,it has remarkable effect,and it has important significance in clinical treatment.

20.
Practical Oncology Journal ; (6): 376-379, 2019.
Article in Chinese | WPRIM | ID: wpr-752872

ABSTRACT

Aberrant crypt foci(ACF)is highly similar to colorectal cancer(CRC)in phenotypic and molecular changes,and is positively correlated with the risk of CRC. It is considered as precancerous lesion of CRC. Many compounds have therapeutic effects on ACF,inhibiting their occurrence and malignant transformation,which can be regarded as a preventive effect on CRC. In this paper,we will review the treatment of ACF by various compounds in different ways in recent years.

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