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1.
Article in English | WPRIM | ID: wpr-880868

ABSTRACT

Mineralized tissue regeneration is an important and challenging part of the field of tissue engineering and regeneration. At present, autograft harvest procedures may cause secondary trauma to patients, while bone scaffold materials lack osteogenic activity, resulting in a limited application. Loaded with osteogenic induction growth factor can improve the osteoinductive performance of bone graft, but the explosive release of growth factor may also cause side effects. In this study, we innovatively used platelet-rich fibrin (PRF)-modified bone scaffolds (Bio-Oss


Subject(s)
Autografts , Bone Regeneration , Cell Differentiation , Humans , Mesenchymal Stem Cells , Osteogenesis , Tissue Engineering , Tissue Scaffolds
2.
Article in Chinese | WPRIM | ID: wpr-535115

ABSTRACT

The immunoregulatory effect of TLSF_(JM) on the expression of T cell IL-2R and protein Tyrosine phosphorylation (PTP) was investigated by immunohistochemistry technique. The results showed that TLSF_(JM) can markedly suppress the expression of IL-2R and PTP on PHA or TPA-stimulated human PBMC and murine IL-2 dependent cell line CTLL-2. However, there was no effect of TLSF_(JM) on the production of IL-1、IL-2 and IL-6 that play an important role in the course of T Lymphocyte prolirferation and differentiation.

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