Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 16 de 16
Filter
1.
Autops. Case Rep ; 11: e2021257, 2021. graf
Article in English | LILACS | ID: biblio-1153184

ABSTRACT

Metastasis to the kidney from other primary sites is extremely rare. Previous studies reported the lung as the most common primary site. Distant metastasis from the tongue to the kidney is exceedingly rare. Herein, we describe a case of metastatic squamous cell carcinoma to the kidney in a 71-year-old male with a detailed discussion of differentiating it from potential mimickers. The patient underwent a total glossectomy and bilateral cervical lymph node dissection. A diagnosis of well-differentiated squamous cell carcinoma of the tongue was rendered and the tumor was staged pT3 pN3b. Within two years of initial presentation, the patient developed widely metastatic disease, including pulmonary nodules, renal masses, left adrenal mass, and pancreatic mass. Accurate diagnosis of a secondary involvement of the kidney by a metastatic tumor requires the appropriate correlation of clinical and imaging findings as well as morphologic and immunohistochemical clues.


Subject(s)
Humans , Male , Aged , Tongue Neoplasms/pathology , Carcinoma, Squamous Cell , Kidney Neoplasms/pathology , Neoplasm Metastasis , Oropharynx , Diagnosis, Differential
3.
Autops. Case Rep ; 11: e2021338, 2021. tab, graf
Article in English | LILACS | ID: biblio-1345357

ABSTRACT

Mucosal Schwann cell hamartoma (MSCH) is a rare benign neurogenic tumor characterized by pure S100p positive spindle cell proliferation. Most cases occur in the distal colon. Involvement of the gall bladder is exceedingly rare. There have been no reports of recurrence or a syndromic association with MSCH. Herein, we describe a case of MSCH of the gallbladder in a 55-year-old female patient with prior history of gastrointestinal neurofibromas who presented with abdominal pain. MR imaging revealed choledocholithiasis, gallbladder thickening, and marked biliary and pancreatic ductal dilation. The patient subsequently underwent cholecystectomy with choledochoduodenostomy. Histologic evaluation of the gallbladder showed diffuse expansion of the mucosa with S100p positive cells with spindly nuclei and indistinct cytoplasmic borders and diagnosis of MSCH of the gallbladder was rendered.


Subject(s)
Humans , Female , Middle Aged , Schwann Cells/pathology , Gallbladder Neoplasms/pathology , Hamartoma/pathology , Neurofibroma/pathology , Neuroma
5.
Autops. Case Rep ; 9(1): e2018057, Jan.-Mar. 2019. ilus
Article in English | LILACS | ID: biblio-986740
6.
Autops. Case Rep ; 8(3): e2018036, July-Sept. 2018. ilus, tab
Article in English | LILACS | ID: biblio-911962

ABSTRACT

Sinus histiocytosis with massive lymphadenopathy, generally known by the name of Rosai-Dorfman disease is a rare benign condition principally affecting cervical lymph nodes. Concurrent extra-nodal disease frequently occurs, however, solitary extra-nodal disease involving the mandible is exceedingly rare with less than five reported cases in the English literature. We describe a case of primary involvement of the mandible in a 27-year-old female, and discuss the differential diagnosis of this disease with other histiocytic lesions.


Subject(s)
Humans , Female , Adult , Histiocytosis, Sinus/diagnosis , Mandible/pathology , Diagnosis, Differential , Erdheim-Chester Disease , Histiocytosis, Langerhans-Cell , Histiocytosis, Sinus/complications , Rare Diseases
10.
Autops. Case Rep ; 8(1): e2018004, Jan.-Mar. 2018. ilus, tab
Article in English | LILACS | ID: biblio-905425

ABSTRACT

Teratomas are one of the most frequent tumors in the pediatric population. They occur anywhere along the midline of the body, following the course of the embryonic germ cell ridge. In the mediastinal location, they exert space occupying effects, leading to a myriad of complications, including non-immune hydrops fetalis. We describe a fatal case of an immature thymic teratoma in a neonate presenting with hydrops fetalis. This case emphasizes the importance of early diagnosis and surgical intervention in such cases.


Subject(s)
Humans , Male , Infant, Newborn , Hydrops Fetalis/diagnosis , Mediastinal Neoplasms/complications , Teratoma/complications , Autopsy , Erythroblastosis, Fetal/diagnosis , Fatal Outcome , Hydrops Fetalis/pathology , Teratoma/diagnosis , Teratoma/pathology
13.
Autops. Case Rep ; 7(4): 37-41, Oct.-Dec. 2017. ilus
Article in English | LILACS | ID: biblio-905404

ABSTRACT

Disseminated toxoplasmosis is a life-threatening disease in immunocompromised individuals. Infection is contracted from handling contaminated soil, cat litter, or through the consumption of contaminated water or food. It is the third most common lethal foodborne infection in the United States. In transplant patients, most cases occur as a result of reactivation of a latent infection resulting from immunosuppression. We present a case of disseminated toxoplasmosis diagnosed at the time of autopsy. This case emphasizes the importance of maintaining a high index of clinical suspicion and active disease surveillance in this era of sophisticated diagnostic testing.


Subject(s)
Humans , Male , Middle Aged , Opportunistic Infections/complications , Toxoplasmosis/complications , Transplant Recipients , Allografts , Autopsy , Fatal Outcome , Heart Arrest/etiology , Immunosuppression Therapy , Kidney Transplantation/adverse effects , Respiratory Insufficiency/etiology , Toxoplasmosis/diagnosis , Toxoplasmosis/pathology
14.
Autops. Case Rep ; 7(4): 51-57, Oct.-Dec. 2017. ilus
Article in English | LILACS | ID: biblio-905407

ABSTRACT

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare and poorly described pancreatic malignancy. It is comprised of mononuclear, pleomorphic, and undifferentiated cells as well as osteoclast-like giant cells (OGC's). It constitutes less than 1% of pancreatic non-endocrine neoplasia and is twice as likely to occur in females as in males. Its histopathologic properties remain poorly understood. It is suspected that UC-OGC is of epithelial origin that can then transition to mesenchymal elements. As part of this study, we describe a case of a malignant pancreatic neoplasm that was discovered in a 69-year old patient as an incidental finding. We also provide an overview of previously published data to highlight UC-OGC's clinical and pathologic features.


Subject(s)
Humans , Male , Aged , Carcinoma, Pancreatic Ductal/complications , Osteoclasts/pathology , Pancreatic Neoplasms/complications , Adenocarcinoma/pathology , Asymptomatic Diseases , Carcinoma, Pancreatic Ductal/pathology , Pancreatic Neoplasms/pathology
15.
Autops. Case Rep ; 7(3): 44-49, July.-Sept. 2017. ilus, tab
Article in English | LILACS | ID: biblio-905326

ABSTRACT

Pulmonary placental transmogrification (PT) is a rare entity with less than 40 cases reported in the literature. Most reported cases are associated with either bullous emphysema or with pulmonary fibrochondromatous hamartomas. We present only the second case of PT associated with adenocarcinoma of the lung. A 67-year-old female with multiple chronic medical ailments presented with shortness of breath and was found to have a 6-cm mass in the upper lobe of her right lung. A computed tomography (CT) guided core biopsy was performed that showed a well-differentiated adenocarcinoma. Interestingly the normal lung tissue showed placental villous architecture. A unique feature of our case is that the diagnosis was made on a needle core biopsy, unlike all the other cases in the literature. We also provide a comprehensive review of this rare entity.


Subject(s)
Humans , Female , Aged , Adenocarcinoma/complications , Biopsy, Needle , Hamartoma/diagnosis , Lung Neoplasms/diagnosis , Pulmonary Emphysema/diagnosis , Diagnosis, Differential , Lung Injury/pathology , Rare Diseases/pathology , Solitary Pulmonary Nodule/diagnosis
16.
Autops. Case Rep ; 7(2): 9-14, Apr.-June 2017. ilus, tab
Article in English | LILACS | ID: biblio-905193

ABSTRACT

Morquio syndrome is a rare lysosomal storage disease that affects multiple organ systems. However, it is rarely associated with malignancy. We present the case of a 30-year old man with Morquio syndrome associated with gastric adenocarcinoma. This case also demonstrates two other findings that have not been previously described in patients with Morquio syndrome - malrotation of brainstem and cerebellum, without clinical neurologic deficit, and persistence of fetal lobulation in the kidneys.


Subject(s)
Humans , Male , Adult , Lysosomal Storage Diseases/pathology , Mucopolysaccharidosis IV/pathology , Autopsy , Brain Stem/abnormalities , Cerebellum/abnormalities , Fatal Outcome , Fused Kidney/pathology , Neoplasms, Second Primary/complications , Stomach Neoplasms/pathology
SELECTION OF CITATIONS
SEARCH DETAIL