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1.
Health Communication ; (2): 67-74, 2021.
Article in English | WPRIM | ID: wpr-914415

ABSTRACT

Background@#: Interprofessional education is a necessary step in preparing healthcare providers. This study was done to develop an interprofessional ethical education for nursing and medical students in South Korea, and examine its effects on their readiness for interprofessional learning and achievement in learning outcomes. @*Methods@#: The study was designed using a one-group pretest-posttest design. The subjects were 34 4th-year nursing students and 39 5th-year medical students who participated in an interprofessional ethical education program. Descriptive statistics, a independent t-test, and a dependent t-test were used for data analysis. @*Results@#: After interprofessional ethical education, students’ readiness for interprofessional learning and achievement in learning outcomes were improved. The improvement of nursing students were higher than that of medical students. @*Conclusion@#: The study results indicate that an interprofessional ethical education for nursing and medical students is effective in increasing their readiness for interprofessional learning and achievement in learning outcomes.

2.
Article in Korean | WPRIM | ID: wpr-920332

ABSTRACT

Purpose@#This study was conducted to identify the factors affecting the quality of life among cancer survivors using the results of the 8th National Health and Nutrition Survey. @*Methods@#Data was collected from the KNHANES Ⅷ-1 (2019). The research tool used the demographic and health related characteristics and quality of life (EQ-5D).Among total 8110 participants, 262 cancer survivors were included in the analysis. Data analysis was conducted using SPSS 25 version. @*Results@#The overall mean of quality of life for participants was 0.92±0.13 (range 0~1).There were statistically significant differences in the quality of life results by age (F=6.23, p<.001), marital status (F=7.40 p<.001), education level (F=12.36, p<.001), current economic activity (t=22.28, p<.001), household income (F=5.49, p=.001), cancer type (t=2.61 p=.018), chronic disease (t=21.29, p<.001), health examination (t=5.39, p=.021), cancer screening (t=4.93, p=.027), activity limitation (t=63.93, p<.001), physical activity (F=4.96, p=.008), monthly drinking (t=8.39, p=.004), depressive symptoms (t=13.52, p<.001), private health insurance (t=20.15, p<.001), body mass index (r=-.17 p=.005), subjective health status (r=.42 p<.001), perceived stress level (r=-.18 p=.003). Factors influencing the quality of life of cancer survivors included cancer screening (β=.21, p=003), education level (β=-.22, p=.003), current economic activity (β=.18, p=.010), subjective health status (β=.19, p=.007), depressive symptoms (β=-.15, p=.034), and physical activity (β=.14, p=.037), which explained 24.5% of the quality of life. @*Conclusion@#To improve the quality of life of cancer survivors, the appropriate intervention is needed for effective management considering various factors which affect the quality of life of the cancer survivors.

3.
Article in Korean | WPRIM | ID: wpr-920153

ABSTRACT

Perilymph fistula (PLF) is defined as an abnormal communication between the middle ear cavity and perilymphatic space of the inner ear. Most cases of PLF are responsible for pressure change caused by internal trauma or external trauma. However, spontaneous PLF might occur without an obvious history of barotrauma. We report two cases of possible spontaneous PLF in the postpartum period: both cases involved progressive sensorineural hearing loss with positional dizziness. Although the leakage of perilymph was not found during exploration, both hearing loss and dizziness improved immediately after PLF repair. It is necessary to consider the possibility of PLF in patients who have sudden or progressive sensorineural hearing loss with positional nystagmus. Early surgical exploration is recommended even if the history of barotrauma is not clear.

4.
Article in Korean | WPRIM | ID: wpr-874710

ABSTRACT

Purpose@#This study aimed to understand and describe the diabetes self-management experience of visually impaired people with diabetes. @*Methods@#Ten participants were recruited through a website used by the visually impaired from February to March 2020. Data were collected through two focus group interviews conducted in June 2020; each group consisted of five participants. All interviews were recorded with the consent of the participants and transcribed verbatim. The transcribed data were analyzed using qualitative content analysis. @*Results@#Seven categories were as follows; a two-faced, lifelong companion, an unprepared encounter, struggle to live, love-hate relationship with family, strategies to adapt, lessening attention to self-management, the desire to learn properly. @*Conclusion@#It can be concluded that the visually impaired have fewer opportunities for receiving diabetes self-management education than general diabetic patients. Consequently, plans to improve the education available to such patients are required. Additionally, psychological counseling and diabetes education for patients’ families are necessary, and improving the perception of medical workers regarding the visually impaired will be prove useful.

5.
Article in English | WPRIM | ID: wpr-917752

ABSTRACT

Background@#The purpose of this study was to explore the employment experiences of mentally disabled employees working in the subsidiary company for the disabled. @*Methods@#Ten people who employed in the subsidiary company for the disabled interviewed with 12 months. The study had a qualitative descriptive design and qualitative content analysis was used. @*Results@#Employment experiences of mentally disabled employees was emerged into three domains (support, effort, expectation and demand), six categories (relational support, supportive work environment, system support, self-management efforts, improving the quality of employment, improving awareness) and 12 subcategories. @*Conclusions@#In conclusion, for stable employment of the mentally disabled peoples, efforts are required at the individual, company, and government level. A flexible and careful work environment for the mentally disabled peoples and support systems such as counseling and case management are needed to be considered. Job assignments that meet the individual skills and needs of persons with mental disabilities should be considered, and it is necessary to develop an integrated supported employment program that supports individual skills training after employment. Above all, a government effort is needed to eliminate social prejudice against mental illness, and also an effort to improve employers' awareness are needed.

6.
Article in English | WPRIM | ID: wpr-917588

ABSTRACT

This study evaluated release of the residual monomer and cytotoxicity after polymerization of three denture base resins (heat curing resin, self-curing resin, light curing resin by 3D printer). Three types of resin specimen according to the manufacturer’s guideline were fabricated: heat curing resin (Group H), self-curing resin (Group S), 3D Printed resin (Group L). Each group of specimen were stored in distilled water at 37 ℃ for 1 day, 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks, and 8 weeks in order to measure the release of the residual monomer. Absorbance was measured at each storage time in the three groups. Cytotoxicity is measured by MTT test at each storage time in the three groups. For statistical analysis, one-way ANOVA with post-hoc tests of Dunnett T3 test and Scheffe test were carried out, where p values of less than 0.05 were considered as significant. Group H showed the lower absorbance than Group S and Group L. There was no statistically significant difference in the absorbance of Group S and Group L for 8 weeks, except for the one day. Group H and Group S showed no cytotoxicity, but Group L resulted in cytotoxicity. To conclude, light curing resin used in 3D printer revealed high cytotoxicity in this study. In order to apply the 3D printed denture base resin to clinical situation, it is necessary to develop a method to reduce the release of residual monomers.

7.
Article | WPRIM | ID: wpr-835728

ABSTRACT

Purpose@#This study aims to measure the mandibular movement using JT-3D system and provide a range of mandibular movement that can serve as a good reference for diagnosing the temporomandibular disorder. @*Materials and Methods@#This study was conducted in 60 young male and female adults. The maximum opening and closing movement was recorded using JT-3D system, and by regarding 5 times of repetitive movement as 1 cycle of movement, total 3 cycles of movement were recorded. During the maximum opening, vertical position of lower jaw, antero-posterior position, lateral deflection position, and maximum opening distance were recorded. To evaluate the reproducibility of JT-3D system, statistical analysis were conducted (α = 0.05). @*Results@#During the maximum opening, the average value appeared at 31.56 mm vertically and 24.42 mm rearwardly, lateral deflection position 0.72 mm, and maximum opening distance 40.32 mm. There was no statistical significance in all measured values for three cycles of movement recorded with JT-3D system (P > 0.05). @*Conclusion@#During the maximum opening, the average value appeared at 0.72 mm in lateral deflection position and the maximum opening distance at 40.32 mm, and the analysis on the maximum opening of lower jaw using JT-3D system showed sufficiently reproducible results.

8.
Article in Korean | WPRIM | ID: wpr-920330

ABSTRACT

Purpose@#This study tried to provide a baseline information for increasing the rate of cancer screening in the elderly by examining the factors influencing cancer screening behavior in the elderly using Andersen's model and health belief model. @*Methods@#Participants included 259 elderly from D city, South Korea. The data were collected from July to August, 2019 using structured questionnaires including subjects' characteristics, knowledge toward cancer screening and health belief variables. @*Results@#The cancer screening rate of the subjects was 66.0%. There were significant differences in monthly income, perception of the National Cancer Screening Program (NCSP), death from cancer in a family member, cancer screening intention, knowledge toward cancer screening, perceived benefit and perceived barrier between two groups. The factors influencing cancer screening behaviors in the elderly were death from cancer in a family member, perception of the NCSP, perceived barrier. @*Conclusion@#This results suggest to increase the rate of cancer screening in the elderly, it is necessary to develop NCSP promotion program and proper education program for the elderly. Additionally, we recommended the research identifying the specific perceived barriers of cancer screening behavior of the elderly. This study provides a reference for developing the policy measures and strategies to increase the cancer screening behavior of the elderly.

9.
Article in Korean | WPRIM | ID: wpr-919751

ABSTRACT

Purpose@#In this study investigated the association between cardio-cerebro vascular disease and depression was examined and factors influencing depression in adults with cardio-cerebro vascular disease were identified. The Korean National Health and Nutrition Examination Survey (KNHANES) data (2014, 2016), which is representative of the Korean population was used. @*Methods@#Data on 9,651 people (male 4,148, female 5,503; age≥19 years old from the KNHANES (Ⅵ-2, Ⅷ-1) were analyzed using frequency, percentage, x2 test, and logistic regression analysis. Depression is defined as major depression with doctor diagnosis or Patient Health Questionnaire-9 score ≥10. Ischemic heart disease (IHD)(myocardial infarction or angina) and stroke were defined as a doctor diagnosis. @*Results@#The prevalence of depression was 20.4% in the IHD group and 22.9% in stroke group, which were statistically significant. After adjusting by sociodemographic, health-related, and independent variables in a logistic regression analysis, IHD (OR=1.91, 95% CI 1.36~2.69) and stroke (OR=1.83, 95% CI 1.23~2.72) were associated with depression. In addition, IHD was significantly associated with depression in women, people divorced or separated, current smokers, people with perceived stress, and hypercholesterolemia. In addition, stroke was significantly associated with depression in women, under the age of 65, with perceived stress. @*Conclusion@#The results of this study show that cardio-cerebro vascular disease is associated with the depression and influencing factors on depression were socio-demographic and health-related characteristics. Therefore, intensive management of depression risk factors and development and application of a program reducing depression for patients with cardio-cerebro vascular disease should be developed.

10.
Article in English | WPRIM | ID: wpr-899237

ABSTRACT

Purpose@#The purpose is to test and evaluate the physical properties of commonly used temporary restoration materials and newly emerged materials. @*Materials and Methods@#Four groups of polymer materials were evaluated: Polymethyl methacrylate (PMMA) 2 groups, Polyetheretherketone (PEEK), Polycarbonate. Four physical properties were tested: surface hardness, bending strength, abrasion resistance during wear, wear behavior. The 3-axis bending strength and Vickers hardness test were measured using a universal testing machines respectively. The microstructure was observed with a scanning electron microscope and weight comparison was evaluated after 100,000 chewing tests using a chewing simulator. Kruskal wallis test was performed to evaluate statistical significance. @*Results@#The four groups showed the highest flexural strength and Vickers hardness of PEEK, followed by PC, PMMA-H, PMMA-T. Microstructure observation also showed the least surface roughness in the PEEK group, followed by PC, PMMA-H, PMMA-T. @*Conclusion@#PC is considered to have sufficient mechanical properties that can be applied to the manufacture of temporary teeth. However, further studies, such as biocompatibility, are considered to be necessary for practical clinical applications.

11.
Article in English | WPRIM | ID: wpr-899223

ABSTRACT

Purpose@#This study investigated the complications and patterns of implants that confronted with the extruded natural teeth. @*Materials and Methods@#Among patients who received implant treatment between 2006 and 2018 at Chosun University Dental Hos-pital, only implants that had a maintenance period of at least 5 years and that both implants and confronting natural teeth could bemeasured and compared on a radiograph were selected. They were divided into two groups. Group 1, experimental group consisted of Implants confronting the extruded natural posterior teeth (n = 167: maxilla (Group 1max ) = 92, mandible (Group 1man ) = 75) and Group 2, control group consisted of Implants confronting the normal natural posterior teeth (n = 656: maxilla (Group 2max ) = 272, mandible (Group 2man ) = 384). @*Results@#The incidence of complications between Group 1 and Group 2 was statistically significant. In particular, there was a statistically significant difference between the frequency of marginal bone loss and the amount of marginalbone loss. @*Conclusion@#The extruded natural tooth may cause more frequent complications including bone resorption in the oppos-ing implant.

12.
Article in English | WPRIM | ID: wpr-891533

ABSTRACT

Purpose@#The purpose is to test and evaluate the physical properties of commonly used temporary restoration materials and newly emerged materials. @*Materials and Methods@#Four groups of polymer materials were evaluated: Polymethyl methacrylate (PMMA) 2 groups, Polyetheretherketone (PEEK), Polycarbonate. Four physical properties were tested: surface hardness, bending strength, abrasion resistance during wear, wear behavior. The 3-axis bending strength and Vickers hardness test were measured using a universal testing machines respectively. The microstructure was observed with a scanning electron microscope and weight comparison was evaluated after 100,000 chewing tests using a chewing simulator. Kruskal wallis test was performed to evaluate statistical significance. @*Results@#The four groups showed the highest flexural strength and Vickers hardness of PEEK, followed by PC, PMMA-H, PMMA-T. Microstructure observation also showed the least surface roughness in the PEEK group, followed by PC, PMMA-H, PMMA-T. @*Conclusion@#PC is considered to have sufficient mechanical properties that can be applied to the manufacture of temporary teeth. However, further studies, such as biocompatibility, are considered to be necessary for practical clinical applications.

13.
Article in English | WPRIM | ID: wpr-891519

ABSTRACT

Purpose@#This study investigated the complications and patterns of implants that confronted with the extruded natural teeth. @*Materials and Methods@#Among patients who received implant treatment between 2006 and 2018 at Chosun University Dental Hos-pital, only implants that had a maintenance period of at least 5 years and that both implants and confronting natural teeth could bemeasured and compared on a radiograph were selected. They were divided into two groups. Group 1, experimental group consisted of Implants confronting the extruded natural posterior teeth (n = 167: maxilla (Group 1max ) = 92, mandible (Group 1man ) = 75) and Group 2, control group consisted of Implants confronting the normal natural posterior teeth (n = 656: maxilla (Group 2max ) = 272, mandible (Group 2man ) = 384). @*Results@#The incidence of complications between Group 1 and Group 2 was statistically significant. In particular, there was a statistically significant difference between the frequency of marginal bone loss and the amount of marginalbone loss. @*Conclusion@#The extruded natural tooth may cause more frequent complications including bone resorption in the oppos-ing implant.

14.
Article in English | WPRIM | ID: wpr-785337

ABSTRACT

PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to the classes IA PI3Ks p110α and p110β. However, the immunological role of PI3K-δ isoform is still controversial in airway epithelium under house dust mite (HDM)-induced allergic response. This study aimed to evaluate the role of PI3K-δ isoform in HDM-induced allergic responses, focusing on NLRP3 inflammasome activation in airway epithelium.METHODS: We used wild-type mice and PI3K-δ knock-out (KO) mice for HDM-induced asthma animal model and also performed in vitro experiments using primary cultured murine tracheal epithelial cells and human airway epithelial cells.RESULTS: PI3K-δ activated HDM-induced NLRP3 inflammasome and epithelial cell-derived cytokines in the lung including airway epithelial cells. PI3K-δ KO mice or knock-down of PI3K-δ using siRNA exhibited the significant reduction in allergic asthmatic features and the suppression of NLRP3 inflammasome assembly as well as epithelial cell-derived cytokines. Interestingly, significantly increased expression of PI3K-δ isoform was observed in stimulated airway epithelial cells and the increases in epithelial cell-derived cytokines were markedly suppressed by blocking PI3K-δ, while these cytokine levels were independent of NLRP3 inflammasome activation.CONCLUSIONS: The results of this study suggest that PI3K-δ-isoform can promote HDM-induced allergic airway inflammation via NLRP3 inflammasome-dependent response as well as via NLRP3 inflammasome-independent epithelial cell activation.


Subject(s)
Animals , Asthma , Cytokines , Dust , Epithelial Cells , Epithelium , Humans , In Vitro Techniques , Inflammasomes , Inflammation , Leukocytes , Lung , Mice , Models, Animal , Phosphotransferases , Pyroglyphidae , RNA, Small Interfering
15.
Article in Korean | WPRIM | ID: wpr-764578

ABSTRACT

PURPOSE: The purpose of this study was to identify nursing students’ knowledge and attitude toward advance directives and factors influencing the attitude. METHODS: A cross-sectional survey design was used and 196 nursing students participated in the study. Data were collected from July 1 to August 30, 2018 using a structured questionnaire which included biomedical ethics, awareness of good death, knowledge and attitude toward advance directives. Data were analyzed using SPSS/WIN 25.0 program with descriptive statistics, t-test, ANOVA, correlation, and multiple regression. RESULTS: The mean score of biomedical ethics, awareness of good death, knowledge and attitude toward advance directives were 2.88±0.59, 3.18±0.48, 7.68±31.32, 31.00±3.09. Factors influencing the attitude toward advance directives were awareness of good death (β=.28, p<.001), intention of writing their advance directives (β=.19, p=.006), the knowledge related to advance directives (β=.15, p=.029). A total of 14% of attitude toward advance directives was explained by awareness of good death, the knowledge related to advance directives, and ntention of writing their advance directives. CONCLUSION: The findings of the study indicate that it is necessary to provide a systemic education program regarding advance directives for nursing students in order to provide knowledge related to advance directives and to help them establish positive attitudes toward advance directives.


Subject(s)
Advance Directives , Bioethics , Cross-Sectional Studies , Education , Humans , Intention , Nursing , Students, Nursing , Writing
16.
Article in Korean | WPRIM | ID: wpr-761458

ABSTRACT

For the success of complete denture, three essential requirements such as retention, stability and support are needed. Moreover, due to the absorption of residual ridge and scarring due to the surgery, when making a complete denture, which is difficult to form the mandibular lingual margins, various considerations such as the arrangement of the Non-anatomical dl non-anatomical teeth, the polished surface impression, the internally weighted metal framework and the use of the denture adhesive cream are necessary. In this case report, the patient has a severely resorbed edentulous ridge from severe periodontitis and has some soft tissue problems after the glossectomy due to tongue cancer. To obtain additional retention and stability, some trials such as polished surface impression taking, internally weighted metal insertion and minimal pressure impression were done for the better result. Moreover To make a metal framework that precisely shapes the desired three-dimensional shape and reduces the complicated process, minimal pressure impression method and direct metal laser sintering technique were used.


Subject(s)
Absorption , Adhesives , Cicatrix , Denture, Complete , Dentures , Glossectomy , Humans , Methods , Periodontitis , Tongue Neoplasms , Tooth
17.
Article in Korean | WPRIM | ID: wpr-760101

ABSTRACT

Cribriform-morular variant papillary thyroid carcinoma (CMV-PTC) is a rare cancer that may arise in patients with familial adenomatous polyposis (FAP). Adenomatous polyposis coli (APC) gene mutation is associated with FAP, which is known as a premalignant lesion of colon cancer. In this report, we report a 16 years old patient of CMV-PTC comorbid with FAP, which was related with a new type of APC gene mutation.


Subject(s)
Adenomatous Polyposis Coli , Colonic Neoplasms , Genes, APC , Humans , Thyroid Gland , Thyroid Neoplasms
18.
Cancer Research and Treatment ; : 1117-1127, 2019.
Article in English | WPRIM | ID: wpr-763168

ABSTRACT

PURPOSE: Recurrence and chemoresistance (CR) are the leading causes of death in patients with high-grade serous carcinoma (HGSC) of the ovary. The aim of this study was to identify genetic changes associated with CR mechanisms using a patient-derived xenograft (PDX) mouse model and genetic sequencing. MATERIALS AND METHODS: To generate a CR HGSC PDX tumor, mice bearing subcutaneously implanted HGSC PDX tumors were treated with paclitaxel and carboplatin. We compared gene expression and mutations between chemosensitive (CS) and CR PDX tumors with whole exome and RNA sequencing and selected candidate genes. Correlations between candidate gene expression and clinicopathological variables were explored using the Cancer Genome Atlas (TCGA) database and the Human Protein Atlas (THPA). RESULTS: Three CR and four CS HGSC PDX tumor models were successfully established. RNA sequencing analysis of the PDX tumors revealed that 146 genes were significantly up-regulated and 54 genes down-regulated in the CR group compared with the CS group. Whole exome sequencing analysis showed 39 mutation sites were identified which only occurred in CR group. Differential expression of SAP25,HLA-DPA1, AKT3, and PIK3R5 genes and mutation of TMEM205 and POLR2A may have important functions in the progression of ovarian cancer chemoresistance. According to TCGA data analysis, patients with high HLA-DPA1 expression were more resistant to initial chemotherapy (p=0.030; odds ratio, 1.845). CONCLUSION: We successfully established CR ovarian cancer PDX mouse models. PDX-based genetic profiling study could be used to select some candidate genes that could be targeted to overcome chemoresistance of ovarian cancer.


Subject(s)
Animals , Carboplatin , Cause of Death , Drug Therapy , Exome , Female , Gene Expression , Genome , Heterografts , Humans , Mice , Odds Ratio , Ovarian Neoplasms , Ovary , Paclitaxel , Recurrence , Sequence Analysis, RNA , Statistics as Topic
19.
Article in Korean | WPRIM | ID: wpr-765648

ABSTRACT

BACKGROUND: External quality assessment (EQA) is important for standardizing cancer biomarker assays, thereby, ensuring accurate and precise results. Although the human epididymis-specific protein 4 (HE4) assay has been increasingly used to detect and monitor ovarian malignancy in Korea, a nation-wide EQA program for HE4 has not been appropriately established. To conduct an EQA program, a large amount of quality control (QC) materials are required. This study aimed to produce HE4 QC materials for an EQA program and evaluate their homogeneity and stability. METHODS: QC materials for three different concentrations of HE4 were produced from the collected remnant sera of 275 patients for whom the HE4 assays were performed. These materials were evaluated for homogeneity between vials and stability during storage. The frozen QC materials were distributed to 13 representative organizations for a provisional EQA. RESULTS: The total coefficient of variation of the HE4 QC materials of three concentrations was 0.75%–1.24%, and no significant differences were noted between vials; therefore, the samples were considered to be homogenous. With respect to stability, the HE4 QC materials were found to be stable till 30 days when frozen and for 24 hours when refrigerated. The results of the provisional HE4 EQA were reviewed and the survey results were reported to each participant. CONCLUSIONS: The HE4 QC materials produced from remnant specimens were found to be homogenous between vials and stable in a frozen condition until 30 days. The findings of this study may be practically applied for establishing a future HE4 EQA program.


Subject(s)
Epididymis , Humans , Korea , Male , Ovarian Neoplasms , Quality Control
20.
Article in English | WPRIM | ID: wpr-762440

ABSTRACT

BACKGROUND: von Willebrand disease (VWD), characterized by quantitative or qualitative defects of von Willebrand factor (VWF), is the most common inheritable bleeding disorder. Data regarding the genetic background of VWD in Korean patients is limited. To our knowledge, this is the first comprehensive molecular genetic investigation of Korean patients with VWD. METHODS: Twenty-two unrelated patients with VWD were recruited from August 2014 to December 2017 (age range 28 months–64 years; male:female ratio 1.2:1). Fifteen patients had type 1, six had type 2, and one had type 3 VWD. Blood samples were collected for coagulation analyses and molecular genetic analyses from each patient. Direct sequencing of all exons, flanking intronic sequences, and the promoter of VWF was performed. In patients without sequence variants, multiplex ligation-dependent probe amplification (MLPA) was performed to detect dosage variants. We adapted the American College of Medical Genetics and Genomics guidelines for variant interpretation and considered variants of uncertain significance, likely pathogenic variants, and pathogenic variants as putative disease-causing variants. RESULTS: VWF variants were identified in 15 patients (68%): 14 patients with a single heterozygous variant and one patient with two heterozygous variants. The variants consisted of 13 missense variants, one small insertion, and one splicing variant. Four variants were novel: p.S764Efs*16, p.C889R, p.C1130Y, and p.W2193C. MLPA analysis in seven patients without reportable variants revealed no dosage variants. CONCLUSIONS: This study revealed the spectrum of VWF variants, including novel ones, and limited diagnostic utility of MLPA analyses in Korean patients with VWD.


Subject(s)
Exons , Genetic Background , Genetics, Medical , Genomics , Hemorrhage , Humans , Introns , Korea , Molecular Biology , Multiplex Polymerase Chain Reaction , von Willebrand Disease, Type 3 , von Willebrand Diseases , von Willebrand Factor
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