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Article in Korean | WPRIM | ID: wpr-759694


Leiomyosarcoma is a rare and aggressive soft tissue sarcoma originating in smooth muscle cells. There are two forms of primary superficial leiomyosarcomas depending on the origin and prognosis, one derived from the dermis and the other from the subcutaneous tissue of the skin. Middle-aged to elderly men are particularly affected by this type of cancer. Leiomyosarcomas of the head and neck are quite rare, accounting for approximately 3%~10% of all cases. We report herein a case of subcutaneous leiomyosarcoma of the scalp in a 47-year-old female patient.

Aged , Dermis , Female , Head , Humans , Leiomyosarcoma , Male , Middle Aged , Myocytes, Smooth Muscle , Neck , Prognosis , Sarcoma , Scalp , Skin , Subcutaneous Tissue
Article in Korean | WPRIM | ID: wpr-716119


Microcystic adnexal carcinoma (MAC) was first described in 1982 by Goldstein. Considered a rare malignant skin appendageal tumor, it is often underdiagnosed due to its clinical and histopathological resemblance to other cutaneous neoplasms. MAC is locally aggressive with infiltration of perineural spaces, subcutaneous tissue, skeletal muscles, and so on. Aggressive treatment including wide local excision, Mohs micrographic surgery, or radiation therapy is necessary owing to the high recurrence rate. Herein, we report a case of a 47-year-old Korean woman with a skin-colored hardened plaque on the scalp with a clinical diagnosis of cicatricial alopecia and histopathological diagnosis of MAC. After treatment by Mohs micrographic surgery, the patient is being followed up regularly without any sign of recurrence. This case demonstrates an uncommon topography of MAC on the scalp with secondary cicatricial alopecia and highlights the need for awareness of the potential for MAC in the diagnosis of alopecia with a slow-growing tumor.

Alopecia , Diagnosis , Female , Humans , Middle Aged , Mohs Surgery , Muscle, Skeletal , Pathology , Recurrence , Scalp , Skin , Skin Neoplasms , Subcutaneous Tissue
Article in English | WPRIM | ID: wpr-715919


Pyoderma gangrenosum (PG) is an uncommon ulcerating inflammatory neutrophilic dermatosis. Multifactorial pathogenesis has been reported because the underlying mechanism needs to be clearly elucidated. A pathergic reaction is a pathogenic aggravating factor of PG. The occurrence of postoperative PG (PPG) within and involving the borders of a surgical incision site suggests the role of a pathergic reaction in PG. Massive debridement should be avoided in PPG, and it should be immediately managed with oral prednisolone. We present 2 cases of PPG with different clinical courses according to the primary management.

Cytokines , Debridement , Neutrophils , Prednisolone , Pyoderma Gangrenosum , Pyoderma , Skin , Skin Diseases , Ulcer
Annals of Dermatology ; : 335-341, 2018.
Article in English | WPRIM | ID: wpr-715490


BACKGROUND: Skin cancer is the most common other primary cancer in patients with lymphoma. However, an intriguing association between cutaneous lymphoma and other primary cancers has been suggested in a few studies. OBJECTIVE: This study investigated other primary cancers in patients with cutaneous lymphoma to evaluate the risk for occurrence of each type of cancer. METHODS: We screened for other primary cancers in 428 patients with cutaneous lymphoma. Clinical features were analyzed according to the lineage and origin of the lymphomas. We calculated the standardized incidence ratio with statistical analysis for each group according to age. RESULTS: Among 330 patients with cutaneous T cell lymphoma and 98 with cutaneous B cell lymphoma, a total of 43 cancers in 38 patients were finally included. Other primary cancers were prevalent in patients with cutaneous B cell lymphoma and patients with secondary cutaneous lymphoma. However, those differences were not significant when the age was calibrated by multiple logistic regression. Metachronously higher standardized incidence ratios were observed for primary lung (standardized incidence ratio [SIR], 14.81; 95% confidence interval [CI], 3.05~39.54), skin (SIR, 68.05; 95% CI, 14.03~181.62), and breast (SIR, 12.91; 95% CI, 1.56~41.41) cancers with statistical significance. CONCLUSION: Other primary cancers more preferentially occurred in patients with cutaneous lymphoma. Clinicians should carefully examine patients with cutaneous lymphoma for other cancers, especially lung, skin, and breast cancers.

Breast , Humans , Incidence , Logistic Models , Lung , Lymphoma , Lymphoma, B-Cell , Lymphoma, T-Cell, Cutaneous , Skin , Skin Neoplasms
Annals of Dermatology ; : 779-781, 2017.
Article in English | WPRIM | ID: wpr-225291


The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS lasers. Two patients with melasma and one patient with PIH were treated with a Picosecond 755-nm Alexandrite Laser (Cyanosure, USA). All patients were Korean with skin type IV and no longer responding to QS laser treatments. Laser treatment was well tolerated in all the patients. Adverse events such as PIH were not reported during 8 weeks of follow up period. After the multiple treatment sessions, one patient reported fair improvement and two patients reported good improvement. Consistent with the clinical results, ex vivo skin model irradiated with a Picosecond 755-nm Alexandrite Laser also showed decreased epidermal keratinocyte necrosis compared with the 532-nm QS Neodymium-Doped Yttrium Aluminium Garnet Laser (Lutronic, Korea) yet decreased melanin content. In conclusion, the Picosecond 755-nm Alexandrite Laser may be useful for effective treatment of intractable melasma and PIH with fewer adverse events in dark Asian skin.

Asian People , Follow-Up Studies , Humans , Hyperpigmentation , Keratinocytes , Lasers, Solid-State , Melanins , Melanosis , Necrosis , Skin , Yttrium