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1.
National Journal of Andrology ; (12): 730-731, 2010.
Article in Chinese | WPRIM | ID: wpr-295009

ABSTRACT

<p><b>OBJECTIVE</b>To explore the feasibility of the treatment of hypospadias with penile and scrotal skin flaps.</p><p><b>METHODS</b>Twenty-three hypospadias patients aged 3.5-19 (mean 6. 8) years underwent urethroplasty with penile and scrotal skin flaps. All were followed up for 6 years and analyzed retrospectively.</p><p><b>RESULTS</b>Of the total number of patients, 21 (91.3%) succeeded in one operation and the other 2 developed complications, including urethral fistula and urethral structure.</p><p><b>CONCLUSION</b>Penile and scrotal skin, advantageous for its adequacy, rich blood supply and contribution to high success rate of surgery, is believed to be the first choice for urethroplasty in the treatment of hypospadias.</p>


Subject(s)
Adolescent , Adult , Child , Child, Preschool , Humans , Hypospadias , General Surgery , Male , Penis , General Surgery , Retrospective Studies , Scrotum , General Surgery , Skin Transplantation , Surgical Flaps
2.
National Journal of Andrology ; (12): 987-992, 2008.
Article in Chinese | WPRIM | ID: wpr-309773

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expressions of VEGF in prostate cancer (PCa) and benign prostatic hyperplasia (BPH), their clinical significance and their relationship with that of ET-1.</p><p><b>METHODS</b>A total of 44 specimens of PCa and 36 of BPH tissues were examined by the immunohistochemical Elivision plus method for the expressions of VEGF and ET-1. The intensity of staining for VEGF and ET-1 was assessed by light microscopy on a scale from "-" to "+ + +".</p><p><b>RESULTS</b>The rates of positive expression of VEGF were 69.4% in BPH and 80.9% in PCa, positive staining mostly in the cytoplasm of glandular epithelia and cancer cells, and strongly positive in all the stroma vascular endothelial cells. The staining intensity of VEGF was significantly higher in the PCa than in the BPH group (P < 0.05) , in the bone metastasis (BM) than in the non-BM group (P < 0.01), and in the lowly than in the highly and moderately differentiated PCa tissues (P < 0.01). The expression of VEGF was positively correlated with that of ET-1 ( r(s) = 0.780, P < 0.01).</p><p><b>CONCLUSION</b>VEGF is involved in the development, progression and metastasis of PCa. VEGF and ET-1 may play a joint role in its development and progression.</p>


Subject(s)
Aged , Aged, 80 and over , Endothelin-1 , Humans , Male , Middle Aged , Neoplasm Metastasis , Neoplasm Staging , Prostatic Hyperplasia , Metabolism , Pathology , Prostatic Neoplasms , Metabolism , Pathology , Vascular Endothelial Growth Factor Receptor-1
3.
National Journal of Andrology ; (12): 927-930, 2008.
Article in Chinese | WPRIM | ID: wpr-309744

ABSTRACT

<p><b>OBJECTIVE</b>To assess the effectiveness and safety of the alphala/d blocker naftopidil in the treatment of benign prostatic hyperplasia (BPH) patients with overactive bladder (OAB) symptoms.</p><p><b>METHODS</b>Fifty BPH patients with OAB symptoms were treated with naftopidil at the dose of 25 mg/d for 6 weeks. A self-controlled clinical trial was conducted. The effectiveness and safety of the drug were observed by comparing the International Prostate Symptom Scores (IPSS), quality of life indexes (QOL), maximum urinary flow rates (Qmax) , average urinary flow rates (Qave), voiding volumes (VV), blood pressures (BP) and heart rates (HR) obtained before and after the treatment.</p><p><b>RESULTS</b>After 6 weeks' medication, the 46 assessable cases showed an average decrease of 9.75 in IPSS (P < 0.01), 3.97 in voiding symptom score (P < 0.01), 5.78 in urinary storage symptom score (P < 0.01) and 1.95 in QOL (P < 0.01), and a mean increase of 4.29 ml/s in Qmax (P < 0.01), 3.75 ml/s in Qave (P < 0.01) and 55.12 ml/s in VV (P < 0.05). But no significant changes were observed in BP and HR. Only 1 patient (4.35%) experienced the adverse event of dizziness.</p><p><b>CONCLUSION</b>The alphalA/D blocker naftopidil is both effective and safe in the treatment of BPH patients with OAB symptoms.</p>


Subject(s)
Adrenergic alpha-Antagonists , Therapeutic Uses , Aged , Humans , Male , Middle Aged , Naphthalenes , Therapeutic Uses , Piperazines , Therapeutic Uses , Prostatic Hyperplasia , Drug Therapy , Urinary Bladder, Overactive , Drug Therapy
4.
National Journal of Andrology ; (12): 685-689, 2007.
Article in Chinese | WPRIM | ID: wpr-232085

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the different expressions of endothelin-1 ET-1) in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissues and their clinical significance.</p><p><b>METHODS</b>A total of 36 BPH and 44 PCa specimens were examined for the expression of ET-1 by immunohistochemical technique (Elivision plus method). The staining intensity for ET-1 was assessed by light microscopy on a scale from "-" to "+ + +".</p><p><b>RESULTS</b>Positive immunoreactivity was found in BPH and PCa, with a positive rate of 100%. Positive staining was located mostly in the cytoplasm of glandular epithelia and smooth muscle cells of both BPH and PCa and was noted in all stroma vascular endothelial cells. These were no significant differences in the intensity of positive staining for ET-1 between the groups of BPH and PCa (P > 0.05), bone metastasis (BM) and non-BM (P > 0.05), and highly and moderately differentiated PCa (P > 0.05), but the staining intensity for ET-1 was significantly higher in the poorly than in the highly and moderately differentiated PCa (P < 0.01).</p><p><b>CONCLUSION</b>ET-1 has a high expression and the localization is the same in both BPH and PCa. It is involved in the development and progression of BPH and PCa.</p>


Subject(s)
Aged , Aged, 80 and over , Endothelin-1 , Humans , Immunohistochemistry , Lymphatic Metastasis , Male , Middle Aged , Prostate , Metabolism , Pathology , Prostatic Hyperplasia , Metabolism , Pathology , Prostatic Neoplasms , Metabolism , Pathology
5.
National Journal of Andrology ; (12): 43-44, 2003.
Article in Chinese | WPRIM | ID: wpr-322554

ABSTRACT

<p><b>OBJECTIVES</b>To assess the clinic efficacy of treating chronic prostatitis by Neisseria gonorrhoeae with azithromycin aspartic-acid injection.</p><p><b>METHODS</b>Nineteen cases were treated with monotherapy and once-daily intravenous dosing of azithromycin injection. The effects and side-effects after treatment were observed.</p><p><b>RESULTS</b>Twelve of nineteen cases were cured.</p><p><b>CONCLUSIONS</b>A short term therapy with azithromycin injection for chronic prostatitis caused by Neisseria gonorrhoeae is very effective and easy to used and thus eliminate any problem of compliance.</p>


Subject(s)
Adolescent , Adult , Anti-Bacterial Agents , Therapeutic Uses , Azithromycin , Therapeutic Uses , Gonorrhea , Drug Therapy , Microbiology , Humans , Injections, Intravenous , Male , Middle Aged , Neisseria gonorrhoeae , Prostatitis , Drug Therapy , Microbiology , Treatment Outcome
6.
National Journal of Andrology ; (12): 517-519, 2003.
Article in Chinese | WPRIM | ID: wpr-237983

ABSTRACT

<p><b>OBJECTIVES</b>To study the occurrence of different anomalies associated with hypospadias and to instruct relevant treatment in clinical practice.</p><p><b>METHODS</b>Three hundred and forty-one cases of hypospadias were investigated, all treated respectively corresponding to their specific anomalies.</p><p><b>RESULTS</b>The morbidity of associated anomalies in cases of hypospadias was as high as 21.1%. Most of the anomaly cases were undescended testes and inguinal hernia, and the incidence of associated anomalies was related to the degree of hypospadias.</p><p><b>CONCLUSIONS</b>Hypospadias is not just a local dysmorphic problem but rather a local manifestation of a systemic disease. It is necessary to take those associated anomalies as a systemic whole and attach enough importance to their clinical treatment.</p>


Subject(s)
Adolescent , Adult , Child , Child, Preschool , Humans , Hypospadias , General Surgery , Male , Urogenital Abnormalities , General Surgery , Urogenital Surgical Procedures , Methods
7.
National Journal of Andrology ; (12): 289-291, 2002.
Article in Chinese | WPRIM | ID: wpr-322589

ABSTRACT

<p><b>OBJECTIVES</b>To evaluate the clinical significance of PSA and ECT bone scans in the diagnosis of bone metastasis in prostate cancer patients.</p><p><b>METHODS</b>Sixty-seven cases of prostate cancer were reviewed, bone metastasis (BM) occurred in 44 cases, and 23 cases without BM (NBM). The relation between PSA, ECT and bone metastasis was analyzed.</p><p><b>RESULTS</b>The sensitivity of BM with bone scan of ECT was 91.67%. Single local density of radionuclide with bone scan was found in 6 cases, only 2 cases have BM. The value of PSA between BM and Non-BM group had significant difference (87.28 micrograms/L vs 25.37 micrograms/L, P < 0.01). PSA and the degree of bone metastasis was positively correlated. PSA < 10 micrograms/L, the morbidity of BM was 0; PSA 10-20 micrograms/L, 7.69%; PSA 20-60 micrograms/L, 53.33%; PSA 60-100 micrograms/L, 91.67%; and PSA > 100 micrograms/L, 100%.</p><p><b>CONCLUSIONS</b>ECT is a high sensitive method in diagnosis of bone metastasis of prostate cancer, but it is not specific in patients with single focus of BM. As for those patients of prostate cancer without any treatment, while PSA < 10 micrograms/L, the morbidity of BM is rare; while PSA > 100 micrograms/L, BM is in high suspect.</p>


Subject(s)
Bone Neoplasms , Diagnostic Imaging , Humans , Male , Prostate-Specific Antigen , Blood , Prostatic Neoplasms , Diagnosis , Diagnostic Imaging , Tomography, Emission-Computed
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