ABSTRACT
Objective To explore the clinical value of multidetector CT angiography in the diagnosis of pulmonary em-bolism (PE). Methods Twenty-three PE patients diagnosed with CTPA were included in the retrospective study. Multi-ple plane reconstruction (MPR), maximum intensity projection (MIP), volume rendering technique (VRT) were performed to analyze the number of thrombi and type of PE. Results The CTPA of 23 patients revealed that totally 169 pulmonary arteries and their branches were affected, there were 13 right or left pulmonary arteries, 40 lobar arteries, 77 segment arteries, 39 subsegment or distal branches, respectively. The types of PE were 65 central, 72 eccentric, 2 luminal ad-hension, 30 obstruction, there were 3 cases of pulmonary infarction, 4 cases of mosaque, 8 cases of pulmonary hyper-tension, 9 cases of pleural ascites, 3 cases of hydrocardiac, 3 cases of fibrosis pulmonary ectasia. Conclusion CT an-giography of MDCT is a noninvasive, safe, rapid, effective exam method for the diagnosis of pulmonary embolism.
ABSTRACT
In-stent restenosis is an important medical problem in interventional therapy .Drug-eluting stent (DES) can significantly reduce in-stent restenosis rate .However ,it also inhibits function and growth of endothelium in stent site while inhibiting over-proliferation of vascular smooth muscle cells .Delayed endothelialization can lead to late restenosis and delayed thrombosis .The present article made an overview on research progress of DES restenosis current condition ,influencing factors ,mechanisms and various therapeutic methods .
ABSTRACT
Objective To evaluate the efficacy of a self-expandable metal stent coated with autologous endothelial progenitor cells(EPCs)for prevention of restenosis in transjugular intrahepatic portosystemic shunt(TIPS)in a swiue model.Methods EPCs were coated on the metal stents using fibrin gel before TIPS procedure.TIPS was performed in 15 young adult pigs,using an autologous EPC-seeded stent(treatment group,n=9)or a conventional bare metal stent(control group,n=6).All pigs were sacrificed at 2 weeks after TIPS procedure.Portography was performed immediately before the euthanasia.Gross and microscopic pathological exams and immunohistochemical exams of the TIPS track specimens were performed.Fisher test and t test were used to analyse the data.Results TIPS was performed successfully in all the 15 swine.On day 14 of follow-up,direct portography and necropsy demonstrated that 5 shunts remained patent,2 shunts stenosed,and the remaining 2 shunts occluded in the treatment group(n=9);while 5 shunts were occluded and one shunt was stenotic in the control group(n=6).The patency rate was 56%vs 0(P=0.03)between the two groups.Histological analyses showed a greater pseudo-intimal hyperplasia in the TIPS track of the control group than that of the treatment group(pseudointimal thickness at hepatic vein,hepatic parenchyma and portal vein site was(1.2±0.4),(1.3±0.5),(1.5±0.4)mmvs(1.0±0.6),(0.9±0.5),(1.0±0.4)mm respectively(P＜0.05).Conclusion The EPC-coated metal stent is feasibly constructed in vitro and improves the patency in TIPS in a porcine model.
ABSTRACT
Deep venous thrombosis is a common disorder, with a considerably high incidence and mortality. Inferior vena cava filter provides fruitful means in decrease and prevention of fatal pulmonary embolism. The authors reviewed the history, indications and applications of inferior vena cava filter for different types of deep venous thrombosis, with outlook of future trends.