ABSTRACT
Objective To explore the effect of insulin sensitizer combined with Diane-35 in the treatment of polycys-tic ovary syndrome (PCOS). Methods A total of 100 cases of PCOS patients were randomly divided into control group and observation group, 50 cases in each group. The control group was treated by with Diane-35 treatment, the observa-tion group based on the use of insulin sensitizing agent. the curative effect, sex hormone levels, the ovulation rate and pregnancy rate, the incidence of adverse reactions were compared between two groups. Results (1) After the treatment, the total clinical effective rate of observation group was 86.00%, was higher than the control group (66.00%),the differ ence was significant(P<0.05); (2) After treatment, FSH, LH, LF/FSH, prolactin, E2 and T levels of the control group were (5.56±1.20) IU/L, (11.65±3.73) IU/L, (2.45±1.61), (16.87±4.02) ng/L, (68.02±13.41) pg/L and (1.71±0.34) pg/L, the levels of the observation group were (4.03±0.56) IU/L, (8.23±1.68) IU/L, (1.43±0.44), (13.01±2.76) ng/L, (53.71±10.25) pg/L and (0.67±0.09) pg/L, differences in hormone levels between the two groups were statistically significant (P<0.05); (3) The ovulation rate and pregnancy rate of control group was 54.00% and 64.00%, significantly less than the observation group (respectively were 80.00% and 86.00%), the differences were statistically significant (P<0.05); (4) There was no adverse reaction happened in two groups. Conclusion Insulin sensitizer combined with Diane-35 in treatment of PCOS has good curative effect, high safety, and is worth to promote and clinical application.