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1.
Article in Chinese | WPRIM | ID: wpr-328242

ABSTRACT

<p><b>OBJECTIVE</b>To observe syndrome types of Chinese medicine (CM) and distribution features of acute infectious diarrhea patients.</p><p><b>METHODS</b>A retrospective study was performed in 465 acute infectious diarrhea patients. The distribution of CM syndrome and syndrome types in different seasons and genders were analyzed.</p><p><b>RESULTS</b>Lack of appetite [381 (81.94%)], fatigue [350 (75.27%)], abdominal pain [338 (72.69%)], tenesmus [325 (69.89%)], anal scorching hot [276 (59.35%)], nausea [25 (55.48%)], diarrhea [249 (53.55%)], short yellow-urine [240 (51.61%)], thirsty [210 (45.16%)], and abdominal distention [206 (44.30%)] were most often seen. The syndrome distribution were sequenced as intestinal damp heat syndrome [268 (57.63%)], dyspeptic retention in intestine and stomach syndrome [106 (22.80%)], cold-damp invading exterior syndrome [47 (10.11%)], Pi-Wei qi deficiency syndrome [23 (4.95%)], cold-damp disturbing Pi syndrome [21 (4.52%)]. The incidence ratio of intestinal damp heat syndrome was the highest in autumn (P < 0.01), while that of cold-damp invading exterior syndrome was the highest in winter (P < 0.01). Cold-damp disturbing Pi syndrome was more often seen in females than in males (P < 0.01), and its incidence ratio was the highest in autumn (P < 0.05). The incidence ratio of dyspeptic retention in intestine and stomach syndrome was the highest in winter (P < 0.01).</p><p><b>CONCLUSIONS</b>Intestinal damp heat syndrome was the most often seen in acute infectious diarrhea. Incidence ratios of in- testinal damp heat syndrome and cold-damp disturbing Pi syndrome were higher in autumn, while those of cold-damp invading exterior syndrome and dyspeptic retention in intestine and stomach syndrome were higher in winter. Cold-damp disturbing Pi syndrome was more often seen in females.</p>


Subject(s)
Diarrhea , Diagnosis , Female , Humans , Male , Medicine, Chinese Traditional , Retrospective Studies , Seasons
2.
Chinese Journal of Epidemiology ; (12): 501-504, 2012.
Article in Chinese | WPRIM | ID: wpr-288143

ABSTRACT

Objective To understand the distribution of hepatitis C virus (HCV) genotypes in China.Methods A national multi-center,large sample epidemiological survey was carried out and certified by an international third-party testing organization.Internationally accepted method for sequencing analysis of viral genotype was used.Results Patients were those suffered from the 4 major genotypes of chronic hepatitis C,including nine subtypes,which were dominated by genotype 1 (69.6%),with type lb in particular (accounting for 68.38% ).Among the rare gene-6,we saw more subtypes of 6a.In the south,central,and north areas,there was no significant difference seen between the south and the north areas in the distribution of the genotype 1.However,the rate of gene type 2a increased gradually from south to north.In terms of less common type of gene 3b and gene-6,they were seen mainly in the southern provinces.Conclusion In China,Patients with chronic hepatitis C had 4 HCV genotypes,with 9 subtypes.The rarely seen genotypes 3b and 6 were mainly distributed in the southern provinces.

3.
Article in English | WPRIM | ID: wpr-344975

ABSTRACT

<p><b>OBJECTIVE</b>To observe the clinical effect of Qingzhen Decoction (QZD) on measles.</p><p><b>METHODS</b>Adopting the randomizing digital table, 62 patients with measles were assigned to two groups, 32 in the treated group and 30 in the control group. All patients were treated with routine therapy, but QZD was given to the treated group additionally for 5 days. Changes of clinical symptoms, blood routine and liver function before and after treatment were observed, and the medical cost was calculated.</p><p><b>RESULTS</b>After the 5-day treatment, the normalization rate of irritative cough in the treated and the control group was 88.9% (24/27) and 56.0% (14/25) respectively, that of conjunctival congestion was 90.0% (27/30) and 65.5% (19/29) respectively, showing significant differences between groups (P<0.05). The liver function normalization rate in the two groups was 28.6% (2/7) and 25.0% (2/8), and the average medical cost yen 740.7 and yen 749.3, respectively. The total effective rate in the two groups was 96.9% and 93.3% respectively, showing insignificant difference between groups (P>0.05).</p><p><b>CONCLUSION</b>QZD could actively improve the respiratory symptoms like irritative cough and the inflammatory symptoms of eye like conjunctival congestion in patients with measles.</p>


Subject(s)
Adolescent , Adult , Antiviral Agents , Therapeutic Uses , Child , Drugs, Chinese Herbal , Therapeutic Uses , Female , Hospitalization , Humans , Length of Stay , Liver Function Tests , Male , Measles , Drug Therapy , Middle Aged , Treatment Outcome
4.
Article in Chinese | WPRIM | ID: wpr-685053

ABSTRACT

The secondary structure of the protein of DM0 and DMT in Oreochromis aureus were predicted by the methods of Garnier-Robson, Chou-Fasman and Karplus-Schulz based on the amimo acid sequences of DM0 and DMT. And Hydrophilicity plot, Surface probability and Antigenic index for DM0 and DMT protein were obtained by the methods of Kyte-Doolittle, Emini and Jameson-Wolf, respectively. Combined the results according to these methods, the B cell epitopes for DM0 and DMT protein were predicted. The results demonstrated that there were some centers of?-helix in the DM0 protein' s N- terminal No. 80 - 112, 144 -147, 193- 194, 251 - 255, 260 - 269 and No. 279- 283, and in the DMT protein' s N-terminal No. 61 -86, 98 - 105, 140 - 146, 239 -241 and No. 269 -273. And there are some centers of?-sheet in the DM0 protein' s N-terminal No. 59 -61, 69 -70, 148 - 150 and No. 383 -390, and in the DMT protein's N-terminal No. 125 -129, 207-213, 255-264 and No. 281-284. Furthermore, the DMO protein' s N-terminal No. 40-41,44 -45, 50-51, 128-129, 189-192, 204-207, 216-222, 226-233, 244-246, 298 - 299 and No. 323 -326, and the DMT protein' s N-termianl No. 12 - 13, 26 - 27, 43 - 44, 58 - 60, 93 - 95, 115 - 120, 136 -139 and No. 149 -151 may be the flexible regions. Moreover the B-cell epitopes possibly localized in or nearby the DMO protein's 1 -5, 41 -51, 65-67, 86-89, 98-110, 154-170, 183-203, 205 -248, 258-264, 284 - 291, 293 - 298, 270 - 375, 389 - 392 and No. 402 - 410, and DMT protein' s N-termianl No. 1 - 9, 17 - 28, 77 - 84, 114 - 123 , 131 - 139, 157 - 184 and No. 96 - 207. Theses results are helpful for studies on sex control mechanism of DMO and DMT in Oreochromis aureus.

5.
Article in Chinese | WPRIM | ID: wpr-331760

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the antiviral efficacy of Bushen Granule (BSG) combined with Marine Injection (MI) in treating patients with chronic hepatitis B of Gan-shen deficiency with Damp-Heat (GSD) syndrome type.</p><p><b>METHODS</b>A total of 90 patients, who were HBV DNA, HBsAg, and HBeAg positive and of GS-DD type, were enrolled, and they were randomly assigned into 2 groups. The 49 patients in the treated group were treated with the combined therapy of BSG and MI and the 41 were administered with lamivudine, the therapeutic course for both groups was 1 year. The negative conversion rate of HBeAg and HBV DNA and the changes in HBV DNA titre, liver function, symptoms and physical signs were observed in the two groups before and after treatment.</p><p><b>RESULTS</b>In the treated group, the negative conversion rate of HBV DNA was 42.6% (20/ 47), insignificantly different to that in the control group (61.0%, 25/41, P > 0.05); the negative conversion rate of HBeAg and HBeAg/anti-HBe sero-conversion rate was 42.6% and 36.2%, respectively, significantly higher than those in the control group (22.0% and 17.0%, P < 0.05); the ALT normalizing rate was 74.4%, higher than that in the control group (51.4%, P < 0.05); the improvement of liver function (ALB and GLB) and clinical symptoms, especially the dizziness, soreness of waist, hypochondrial distending pain, and yellowish urine, were significantly superior to those in the control group(P < 0.01 or P < 0.05); and the partial response rate was 29.8%, insignificant different to that in the control group (14.6%, P > 0.05).</p><p><b>CONCLUSIONS</b>Combined treatment of BSG and MI has an ideal short-term effect in treating patients with chronic hepatitis B of Gan-shen deficiency with Damp-Heat syndrome type, it can inhibit HBV replication and improve patients' liver function and physical signs.</p>


Subject(s)
Adolescent , Adult , Diagnosis, Differential , Drugs, Chinese Herbal , Therapeutic Uses , Female , Hepatitis B, Chronic , Drug Therapy , Virology , Humans , Injections, Intravenous , Male , Medicine, Chinese Traditional , Middle Aged , Phytotherapy
6.
Article in Chinese | WPRIM | ID: wpr-234844

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the therapeutic effect of Danning Tablet (DNT) on patients with non-alcoholic fatty liver (NAFL) of damp-heat Syndrome type.</p><p><b>METHODS</b>Multi-center randomized double-blinded positive medicine parallel controlled method was adopted. One hundred and two patients were treated with DNT and 33 patients treated with Ursodeoxycholic acid (UDCA) as control. Indexes including body mass index (MBI), principal symptom, liver function, blood lipids, iconographic parameters and comprehensive efficacy were measured before and after treatment in the two groups respectively.</p><p><b>RESULTS</b>DNT and UDCA had the effect in improving BMI, distress in hepatic region, fatigue, anorexia, liver function, blood lipids and iconographic parameters, etc. DNT showed effects in improving BMI and distress in hepatic region better than those of UDCA. Histological examination also showed that DNT had good therapeutic effect.</p><p><b>CONCLUSION</b>DNT is an effective medicine for NAFL patients of damp-heat Syndrome type, and its efficacy is better than that of UDCA.</p>


Subject(s)
Adult , Diagnosis, Differential , Double-Blind Method , Drugs, Chinese Herbal , Therapeutic Uses , Fatty Liver , Classification , Drug Therapy , Female , Humans , Male , Medicine, Chinese Traditional , Middle Aged , Phytotherapy , Tablets , Treatment Outcome
7.
Article in Chinese | WPRIM | ID: wpr-269902

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between basal core promoter (BCP) combined point mutation of hepatitis B virus (HBV) and TCM syndrome type.</p><p><b>METHODS</b>One hundred and two patients with chronic hepatitis with positive HBV DNA and hadn't ever been treated by Lamivudine and interferon were differentiated according TCM syndrome differentiation into 5 types, two excess types (damp-heat blocking zhong-jiao type and blood stasis blocking collaterals type) and three deficiency types, gan-stagnation with pi-dificiency type, gan-shen yin-deficiency type and pi-shen yang-deficiency type. The serum HBV DNA, hepatic biochemical indexes, and the mutation of BCPnt 1762A-T and nt1764G-A combined point were determined, respectively.</p><p><b>RESULTS</b>The variant strain positive rate detected in the excess type was significantly higher than that in the deficiency type, the highest rate appeared in patients of damp-heat blocking zhong-jiao type.</p><p><b>CONCLUSION</b>BCP combined point mutation may be liable to happen in patients of TCM excess type, especially in patients of damp-heat blocking zhong-jiao type.</p>


Subject(s)
Diagnosis, Differential , Hepatitis B Core Antigens , Genetics , Hepatitis B virus , Genetics , Hepatitis B, Chronic , Diagnosis , Virology , Humans , Medicine, Chinese Traditional , Point Mutation , Promoter Regions, Genetic , Genetics
8.
Article in Chinese | WPRIM | ID: wpr-320253

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of Anti-fibrosis Compound contained serum (AFCS) on procollagen type I and IV (ProC-I and ProC-IV), matrix metalloproteinase (MMP) and its tissue inhibitor (TIMP-1) gene expression in hepatic stellate cell line LI90 (HSC-LI90).</p><p><b>METHODS</b>AFCS was prepared by gastric infusing different dosage (0.5 g/kg, 2.0 g/kg and 4.0 g/kg) of Anti-fibrosis Compound Recipe to rats. After HSC-LI90 cells were exposed to AFCS for 48 hrs, levels of ProC-I, ProC-IV, gene expression of MMP-2, MMP membrane type 1 (MT1-MMP) and TIMP-1 in the cells were detected by Northern blot, and gelatinase activity of MMP-2 was measured by zymography.</p><p><b>RESULTS</b>AFCS of different concentrations could inhibit ProC-I and ProC-IV and TIMP-1 gene expression (P < 0.05 or P < 0.01), increase MT1-MMP gene expression (P < 0.01), but it showed no effect on gene expression and activity of MMP-2 (P > 0.05).</p><p><b>CONCLUSION</b>Anti-fibrosis Compound Recipe has anti-liver fibrosis action, its effects in inhibiting TIMP-1 gene expression of HSC-LI90 cells and promoting degradation of collagen might be one of the mechanisms of the action.</p>


Subject(s)
Animals , Cell Line , Collagen Type I , Genetics , Collagen Type IV , Genetics , Drugs, Chinese Herbal , Pharmacology , Female , Gene Expression , Hepatocytes , Metabolism , Pathology , Liver Cirrhosis , Blood , Metabolism , Pathology , Male , Matrix Metalloproteinase 2 , Genetics , Matrix Metalloproteinases , Genetics , Rats , Rats, Wistar , Serum , Tissue Inhibitor of Metalloproteinase-1 , Genetics
9.
Article in Chinese | WPRIM | ID: wpr-240943

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of combined application of Lamivudine and Bushen recipe (BSR) in treating patients with chronic hepatitis B (CHB) and its influence on tyrosine-methionine-aspartate-aspartate (YMDD) motif.</p><p><b>METHODS</b>Eighty-eight patients of CHB with positive HBV-DNA were divided into 3 groups, Group A treated with Lamivudine, Group B treated with Lamivudine plus BSR1 and Group C treated with Lamivudine plus BSR2, the serum HBV-DNA, hepatic biological parameters and YMDD motif mutation were observed.</p><p><b>RESULTS</b>The positive rate of HBV-DNA (6.45%) and YMDD motif mutation (3.23%) in Group C were lower than those in Group A respectively, after 52 weeks treatment.</p><p><b>CONCLUSION</b>Combined application of Lamivudine and BSR could enhance the therapeutic effect in treating CHB to certain extent, and could reduce the mutation of YMDD motif.</p>


Subject(s)
Adolescent , Adult , Amino Acid Motifs , Genetics , Antiviral Agents , Therapeutic Uses , Conserved Sequence , Drug Therapy, Combination , Drugs, Chinese Herbal , Therapeutic Uses , Female , Hepatitis B virus , Genetics , Hepatitis B, Chronic , Drug Therapy , Humans , Lamivudine , Therapeutic Uses , Male , Middle Aged , Mutation , Phytotherapy
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