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Article in Chinese | WPRIM | ID: wpr-490840


Objective To compare the difference in radiotherapy dose caused by different ways of adding bolus.Methods A total of 20 patients who needed to receive postmastectomy chest wall irradiation from October to December on 2014 were selected.Each patient underwent two CT scans;CT-1 was to perform CT scan directly without bolus, and CT-2 was to perform CT scan after adding bolus to the body surface.An equivalent bolus was added for CT-1 in the radiotherapy planning system, and Plan-1, which met the clinical requirements, was performed.Then Plan-1 was put on CT-2 through image fusion and plan verification to develop Plan-2, which was to develop plans with equivalent boluses at other times and perform radiotherapy with a bolus added to the surface of the body.At last, CT-2 was used to perform radiotherapy Plan-3, which met the clinical requirements.The paired t-test was used for comparison of clinical data between any two plans with SPSS 19.0.Results The V20 of the whole lung, V20 of the diseased lung, V30 of the heart, and Dmax of the healthy breast showed no significant differences across the three plans (P=0.074-0.871).The V50 , V55 , conformity index, and homogeneity index of the planning target showed significant differences across the three plans, and the total number of monitor units showed a significant difference between Plan-1 and Plan-2(P=0.002-0.049).The dose distribution in the target volume and the number of monitor units in each radiation field also showed significant differences.Conclusions When the equivalent bolus is added to the body surface before CT scan, such a plan can accurately reflect the dose distribution of the planning target and the dose to organs at risk.

Article in Chinese | WPRIM | ID: wpr-553701


Objective To investigate the relationship between coronary heart disease patients with heart fail -ure and natriuretic peptide ( BNP) and c-reactive protein ( hs-CRP) ,and provide the clinical basis .Methods 160 cor-onary heart disease patients with heart failure were selected as the observation group ,and 200 health individuals as the control group .The BNP and hs-CRP with heart failure were analyzed .Results BNP and hs-CRP of the observation group were(481.5 ±57.8)pg/mL and(12.4 ±2.9)mg/L,which were higher than that of the control group [(41.2 ± 9.6)pg/L vs(3.8 ±1.1)mg/L],the difference was statistically significant (t=13.17,5.28,all P<0.05);Left ven-tricular ejection fraction(LVEF)of the observation group was (41.9 ±6.3)%,lower than that of the control group (60.2 ±8.4)%,the difference was statistically significant (P<0.05);BNP and hs-CRP of grade Ⅰ,Ⅱ,Ⅲ and Ⅳincreased with the grade ,the differences were statistically significant ( t=5.20,10.11,12.42,4.18,5.02,3.98,all P<0.05);By Logistic analysis,serum BNP and hs-CRP were associated with heart failure of coronary heart disease . Conclusion Coronary heart disease patients with heart failure cardiac function were associated with BNP and hs -CRP,and with grade were gradually increasing that BNP and hs-CRP increased.